This week, we'll be looking at a common starting point for medicating against Depersonalisation Disorder: the combination of an SSRI antidepressant and Lamotrigine.
This is by no means an 'official' medication for DPD and there is no "one-pill-cures-all" approach to treating it. But, this combination is often the most common starting point when using medication to treat DPD, as it's the medication that has shown the most promise in all the drug trials.
It's also the combination that I am taking - and have recently reached the target 'treatment' dose of both medications. Quite a few of you have asked me how I've been getting on with it & whether I've had any side effects - so I'll discuss that in this video too.
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**Disclaimer** I am not a trained professional in any way. This channel is comprised largely of my own personal opinions & experiences as a DPD sufferer. I do lots of research about DPD and have spoken to many professionals - I endeavour to include their knowledge within my videos, but it's inevitable that at some point I may get medical facts slightly wrong. Please don't use the content of this channel for your own self-diagnosis...use it to learn about Depersonalisation, engage in discussion with others and - if appropriate - assist you in gathering information to then discuss with your doctor or mental health professional.
I've been on Citalopram for a few years and have just managed to get a psychiatric practitioner to prescribe me Lemotragine. Looking forward to seeing if it has any positive effect. 30mg of the SSRI and just starting the Lemotragine so will be building up from now
Hi There, I’ve been badly struggling with this for 20 years after taking extremely potent magic mushrooms and cannabis in Amsterdam...been hospitalised et al
I’ve been on very low dose of an antipsychotic called Trifluoperazine (3mg per night), and a low dose of Citalopram (20mg per night) for the last 18 years
The first med deals with the severe anxiety I have as a result of DP, and the second deals with the anxiety and mild depression
I feel like these meds are only treating the co-morbid symptoms of DP, not the actual problem itself
...although I’m shit scared to come of the meds and try something different as my world literally caves in when I don’t have these meds
Arghhhhh, just don’t know what to do...want to do something about it but I have a mortgage and responsibilities - I can’t go to work without the meds
I was on sertraline upto the highest dose 200 mg for a year but I didnt notice any positive effect. I noticed some side effects: fatigue, more drowsiness, weight gain, problem with sleep and appetite but they went away as I progressed with the meds. I have since changed meds 2-3 times and am currently on the highest dose for vortioxetine. I still havent seen any positive change and I feel more depersonalised now than ever. I have asked my psychiatrist if we can try lamotrigine but he has always declined it saying he doesnt prefer it . My GP too cant prescribe it.
I believe it's the combination of the SSRI and Lamotrigine together that are thought to have some effect on some people's DP - the two on their own are less effective. It might be worth showing your psychiatrist the British Medical Journal article on DP/DPD as it explains it pretty well - and from memory, I think it mentions the SSRI/Lamotrigine combo.
This combo didn't work for me DP wise. I'm currently on 100mg sertraline once in the morning, and was up to 300mg lamotrigine in the morning as well after building the dosage gradually over months. I was feeling GREAT mood wise for about a month on 300mg but suddenly I was having paranoid super anxious thoughts, dry mouth and the inability to pee the final few drops and mania. I brought it down to 100mg, side effects dissipated for the most part but my mood is now meh again and my dp is more or less the same. Tried risperidone twice but it just made me a husk and actually worsened my DP. I dont know what to do anymore. Its Been 16 years constantly with this nightmare. I wish to try naloxone/naltrexone/nalmefeme but its difficult to get a prescription
Try some Kratom, just order it online from reputable website. Kratom contains opiate agonists and antagonists (Naloxone /Naltrexone is an antagonist). I used to be on prescription Naloxone for 4 years and it worked for my depersonalisation, however the physical restrictions around the ordering and collection of that script was interfering with my personal life and I made the decision to stop taking it, my depersonalisation returned - I now take Kratom which works in exactly the same way as Nalxone did for me for depersonalisation, plus it has the added bonus of acting liek an antidrepressant for my mood, which is even better for anyone with depersonalisation. And I too have had this awful disorder for 16 years funny enough :)
Sorry to hear all of that :-( I'm surprised that - despite it being believed that my DP is neither due to anxiety nor depression - that being on 150mg of Sertraline and 200mg of Lamotrigine, I'm yet to notice any effect on my mood whatsoever. I would have thought I'd have felt something by now...but nothing yet! I'd definitely recommend seeing a Neuropsychiatrist if you haven't already...in my experience, they've been the ones who have known the most about DP and have had better ideas about how to try tackling it.
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