Get ya 4pack www.theamberinstitute.com This how to is dependant on taking the 4Pack Daily!!!!! Get your 4pack on sale now at www.theamberinstitute.com Please text me directly 702-845-9814 I really appreciate your support! DROPPED MY IPHONE IN THE WATER TEXT ME AT 718-989-1955
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This is a review of L-Theanine amino acid for high blood pressure. Benefits of L-Theanine for stress, anxiety, and blood pressure reduction. I've been taking 200 mg on an empty stomach first thing in the morning and 200mg in the afternoon about 3pm. This video is about what L-Theanine has done to reduce my blood pressure which was caused by stress. If your hypertension is high for other reasons, L-Theanine may not work for you. This is my own personal experience and beliefs. Statements have not be evaluated by the FDA. This video is not medical advice. Please consult with your doctor if your blood pressure is high. Stopping blood pressure medicine is very dangerous and should only be done under a doctor's supervision.
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Kratom & Vendor Guide: http://roosterdating.com/beginners-kratom-guide/ Favourite L-Tyrosine: https://amzn.to/2DoFpSZ HappyHippo Review: http://roosterdating.com/hippo-review/ CoastlineKratom Review: http://roosterdating.com/coastlinekratom-review/ Thanks for watching! If you have any questions, feel free to email me at firstname.lastname@example.org Disclaimer: The information provided in this video is given for harm reduction, educational, or information uses only, and is provided without prejudice. No information obtained from this video and/or Youtube channel should be construed as medical advice, advocating, promoting, or advising any behaviors or actions in violation of the laws in your local country, including misuse of products obtained from internal or external sources. This video is not intended to be a substitute for professional medical diagnosis or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. These statements have not been evaluated by the Food and Drug Administration.
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Best nutritional supplements for hypertension. Here are the supplements I took to lower blood pressure in just 10 days. Pros and cons of nutritional supplements. What worked for me, may not work for you. Never stop taking blood pressure medicine unless your doctor gives you permission. This video is NOT medical advice. Statements have not been evaluated by the FDA. UPDATE: Since making this video I've done other things that have brought my BP consistently into the normal 120/70 range without medicine.
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An “all-in-one” formula for instantly increasing your energy levels and improving memory: 👉 http://drsam.co/yt/MoreEnergy Or you can watch this video: http://drsam.co/yt/SleepLessAndMoreEnergy References - J Altern Complement Med. 2011 Jul;17(7):635-7. - Unpublished data on file. Frutarom 2015. - J Physiol Anthropol. 2012 Oct 29;31(1):28. - Milgram NW, Callahan H, Siwak C Adrafinil: A Novel Vigilance Promoting Agent . CNS Drug Rev. (2006) - Brain Res. 2007 Oct 10;1173:117-25. - Biol Psychiatry. 2012 Feb 15;71(4):294-300. - http://www.neuravena.com/science ======================================= 🛏️ How To Sleep Less, Have More Energy & Live Longer ======================================= I mention this because today I’m going to reveal my 3 favorite, clinically proven herbs that will instantly increase your dopamine levels and thus, improve your energy, mood and desire. Now, many people know Dopamine as a “feel good chemical”. More specifically, Dopamine is a neurotransmitter that regulates mood and cognition. Dopamine is involved in motivation, addiction, attention, lust, desire and happiness. But the problem here is that as great as you feel with the increase in dopamine, the LESS sensitive your dopamine receptors become and thus, you need MORE “stimulation” to get the same “happiness” or “high”. Thus, one reason for “addiction”. Unfortunately, dopamine levels decline as we age resulting in decreased mental performance, depression, "drive", energy levels, happiness, Parkinson's disease and accelerated brain aging. Now, one of the best ways to improve this is to take herbs which naturally increase both dopamine levels AND dopamine receptor sensitivity. When these 3 clinically proven herbs are combined in the correct dosage and extract, you’ll have: elevated brain dopamine levels 74% improvement in mental acuity. 57% improvement in mental processing time and speed increase alpha-brain waves and electrical brain activity improved mood and better relaxation. My Three Favorite Herbal Extracts Okay, so let’s get started. Velvet Bean extract (Mucuna pruriens) (20% catecholamines; 15% L-dopa extract) While L-DOPA can cross the blood-brain barrier, dopamine cannot, making L-DOPA the preferred compound to elevate brain dopamine levels. Neuravena® Wild Green Oat extract inhibits the monoamine oxidase-B (MAO-B) enzyme. This is important, because age-related decline in dopamine is largely caused by rising levels of MAO-B. In a double-blind, randomized, placebo-controlled trial, there was a 74% improvement on a standard test of mental acuity 6 and 57% improvement in mental processing time and speed Neuravena is the only clinically proven form of wild green oat extract shown to acutely improve attention and concentration as well as the ability to maintain task focus in older adults. It's also been proven to enhance cerebral vasodilation, which can help improve cognition and reduce the formation of plaque in the brain. Great Tea Extract / L-Theanine Great tea extract has small amounts of an amino acid called L-Theanine. You’ll need to drink a LOT of green tea to get the clinical benefits of L-Theanine, so that’s why I just recommend taking L-Theanine by itself. Now, L-Theanine produces calming effects in the brain by increasing levels of serotonin and dopamine, and blocking the binding of L-glutamic acid to glutamate receptors.25-31 This allows L-theanine to cross the blood-brain barrier and increase dopamine levels in your brain. The calming, mood-enhancing effect is achieved by helping to increase alpha-brain waves, electrical brain activity commonly present when you are very relaxed, literally putting you in a better mood.30 Now, even though you are relaxed, your energy levels are higher. Additionally, It has anti-depressant and anti-anxiety effects, reduces mental and physical stress, and leads to improvements in learning and memory in humans and animals. The Best Combination That’s Clinically Proven However, the good news is that if you want to increase your energy levels, mood, cognition, memory and physical stamina by optimizing your youthful hormones and neurotransmitters such as dopamine, stress hormones, ATP, and mitochondria, I suggest using one of my favorite all-natural solutions called Body-Brain Energy. Now, I recommend Body-Brain Energy because it already combines these 3 ingredients with other, clinically proven ingredients…. at the correct extract AND dosage amount. ======================================== Thank you for watching. Please feel free to comment, like or share with your friends. Subscribe to Dr.Sam Robbins's official Youtube channel http://drsam.co/yt/subscribe Like us on Facebook https://www.facebook.com/DrSamRobbins Visit Dr.Sam Robbins's blog for more information on your health! http://www.drsamrobbins.com/ ======================================== Thanks DrSamRobbins
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These videos are designed for medical students studying for the USMLE step 1. Feel free to comment and suggest what you would like to see in the future, and I will do my best to fulfill those requests.
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Take Dr. Berg's Free Keto Mini-Course: http://pxlme.me/-i717vtY Dr. Berg talks about the two minerals and depression. The first one is chromium. Chromium help your blood sugars become stable. Taking 600 mcg per day can help stabilize blood sugars, which then stabilize the mood. It is really the low blood sugars that effect the mood, and the lowered mood is the effect, not the cause. Zinc also is necessary for the production of insulin. So if insulin is not present in the body or not "available" due to insulin resistances, the cells cant get it. If there is not enough insulin, not enough glucose can feed the cell. Take 30 mg of zinc to support this condition. The brain is the target for low sugars. And if you have insulin resistance, you not only get low levels of glucose you also get low levels of amino acids in the cell, which are necessary for the production of neurotransmitters like serotonin and dopamine which elevate your mood. Dr. Eric Berg DC Bio: Dr. Berg, 52 years of age is a chiropractor who specializes in weight loss through nutritional and natural methods. His private practice is located in Alexandria, Virginia. His clients include senior officials in the U.S. government and the Justice Department, ambassadors, medical doctors, high-level executives of prominent corporations, scientists, engineers, professors, and other clients from all walks of life. He is the author of The New Body Type Guides, published by KB Publishing in January 2017. Dr. Berg trains chiropractors, physicians and allied healthcare practitioners in his methods, and to date he has trained over 2,500 healthcare professionals. He has been a past member of the Endocrinology Society, and has taught students as an adjunct professor at Howard University. DR. BERG'S SHOP: http://shop.drberg.com/ Follow us on FACEBOOK: fb.me/DrEricBerg Send a Message to Dr. Berg and his team: m.me/DrEricBerg TWITTER: http://twitter.com/DrBergDC DR. BERG'S VIDEO BLOG: https://www.drberg.com/blog YOUTUBE: https://www.youtube.com/user/drericbe... ABOUT DR. BERG: https://www.drberg.com/dr-eric-berg/bio DR. BERG'S STORY: https://www.drberg.com/dr-eric-berg/s... DR. BERG'S HEALTH COACHING TRAINING: https://www.drberg.com/weight-loss-coach DR. BERG'S REVIEWS: https://www.drberg.com/reviews Disclaimer: Dr. Eric Berg received his Doctor of Chiropractic degree from Palmer College of Chiropractic in 1988. His use of “doctor” or “Dr.” in relation to himself solely refers to that degree. Dr. Berg is a licensed chiropractor in Virginia, California, and Louisiana, but he no longer practices chiropractic in any state and does not see patients. This video is for general informational purposes only. It should not be used to self-diagnose and it is not a substitute for a medical exam, cure, treatment, diagnosis, and prescription or recommendation. It does not create a doctor-patient relationship between Dr. Berg and you. You should not make any change in your health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis, and recommendation. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. The Health & Wellness, Dr. Berg Nutritionals and Dr. Eric Berg, D.C. are not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this video or site.
Просмотров: 40085 Dr. Eric Berg DC
Tyrosine is one of the most important amino acids, which used in synthesis structural proteins. L tyrosine is a nonessential amino acid (protein building block) that this supplement has been used in connection with the following health conditions 28i've taking l and 5 htp for depression anxiety about three my wife uses product because her underactive thyroid leaves possible side effects. Benefits of acetyl l tyrosine what is good for? Health benefits and uses xtend life. Benefits of l tyrosine nutritional supplements health guide. It is one of the 22 amino acids that are used by cells human body l tyrosine to synthesize proteins. Iherb customer reviews now foods, l tyrosine, 500 mg the side effects of taking too much tyrosine. As you stress is an inescapable part of human existence and in extreme forms can cause or exacerbate psychiatric disorders, including depression, schizophrenia l tyrosine side effects include overstimulation, restlessness, anxiety, insomnia. It is one of the 22 amino acids that human body uses to build proteins. L tyrosine benefits what it does and why you should care! youtube. L tyrosine is a non essential amino acid, meaning you don't need to obtain it from diet as long 18 dec 2013 l helps your body manufacture several important neurotransmitters that regulate mood an acid known chemically 4 hydroxyphenylalanine. L tyrosine to alleviate the effects of stress? Ncbi nih. Negative side effects of l tyrosine pure nootropics. L tyrosine is an amino acid that used to produce noradrenaline and dopamine; Supplemental appears be anti stress for acute stressors (which tend find patient medical information on webmd including its uses, acid, acetyl l tyrosine, actyl n how benefits your body. L tyrosine is one of the amino acids that are important for protein and neurotransmitter synthesis in your body. L tyrosine scientific review on usage, dosage, side effects. Although proteins are tyrosine l is also known by the chemical name of 4 hydroxyphenylalanine. L tyrosine there are plenty of negative side effects l tyrosine, but they may not be as bad you think. The benefits of l tyrosine stems from the fact that it facilitates many processes related to brain functioning. Free shipping for orders over $35 describes uses the nutritional supplement l tyrosine, side effects it may have, and interactions with foods, medications, or other supplements 31 2017 home 8 proven health benefits of tyrosine 1) replenishes cognitive resources used in memory; 2). Rapid heart beat, palpitations or arrhythmias are potential side 20 apr 2006 the properties and effects of tyrosine, according to information l tyrosine overcame a tolerance appetite reducing uses. L tyrosine benefits, side effects and dosages guide nootriment. At present, it is n acetyl l tyrosine benefits users by enhancing mood and maintaining blood pressure levels during times of stress. How l tyrosine benefits your body xbrain. Tyrosine supplement benefit and side effects, dosage, safety, 2
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You Gotta Check This Website Out! http://healingideas.org/ Link to the Study - https://pubchem.ncbi.nlm.nih.gov/compound/L-tyrosine Recommended Supplements - NOW L-tyrosine 500mg,120 Capsules http://amzn.to/2C36v0c L-Tyrosine is a non-essential amino acid that plays an important role in the production of neurotransmitters dopamine and norepinephrine. In addition, because L-Tyrosine is necessary for the synthesis of thyroid hormone and epinephrine (adrenaline), L-Tyrosine supports healthy glandular function and stress response.* Tyrosine Neurotransmitters, Brain, Hormones, Thyroid, Melanin, Proteins, Stress, Depression, Mood, Memory, Mental Alertness, Parkinson’s Tyrosine is an essential amino acid that readily passes the blood-brain barrier. Once in the brain, it is a precursor for the neurotransmitters dopamine, norepinephrine and epinephrine, better known as adrenalin. These neurotransmitters are an important part of the body's sympathetic nervous system, and their concentrations in the body and brain are directly dependent upon dietary tyrosine. Tyrosine is an important amino acid in many proteins, peptides and even enkephalins, the body's natural pain reliever. Tyrosine is also the precursor for hormones, thyroid, catecholestrogens and the major human pigment, melanin. More tyrosine is needed under stress, and tyrosine supplements prevent the stress-induced depletion of norepinephrine and can cure biochemical depression. The availability of L-tyrosine determines psychological and physiological effects of stressful situations including hypotension, cold and behavioral stress. It can act as a mood elevator and an anti-depressant. It may improve memory and increase mental alertness. However, tyrosine may not be good for psychosis. Many antipsychotic medications apparently function by inhibiting tyrosine metabolism. L-dopa, which is directly used in Parkinson's, is made from tyrosine. Tyrosine, the nutrient, can be used as an adjunct in the treatment of Parkinson's. Peripheral metabolism of tyrosine necessitates large doses of tyrosine, however, compared to L-dopa. It’s also a component of active thyroid hormones (thyroxin), supports healthy thyroid function. Tyrosine deficiencies are manifested by hypothyroidism, low blood pressure and low body temperature. Supplemental tyrosine has been used to reduce stress and combat narcolepsy and chronic fatigue. In the liver, L-tyrosine is involved in a number of biochemical reactions, including protein synthesis and oxidative catabolic reactions. L-tyrosine that is not metabolized in the liver is distributed via the systemic circulation to the various tissues of the body. L-tyrosine is a non-essential amino acid. In animals it is synthesized from PHENYLALANINE. Tyrosine is not found in large concentrations throughout the body, probably because it is rapidly metabolized. Folic acid, copper and vitamin C are cofactor nutrients of these reactions. Valine and other branched amino acids, and possibly tryptophan and phenylalanine may reduce tyrosine absorption. A number of genetic errors of tyrosine metabolism occur. Most common is the increased amount of tyrosine in the blood of premature infants, which is marked by decreased motor activity, lethargy and poor feeding. Infection and intellectual deficits may occur. Vitamin C supplements reverse the disease. Some adults also develop elevated tyrosine in their blood. This indicates a need for more vitamin C.
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The pathway of vasopressors (Tyrosine, L. Dopa, Dopamine, Norepinephrine, Epinephrine) and a look at the use of vitamin C in the setting of septic shock. This is video 1 of the Vasopressors Series at https://www.medcram.com/courses/vasopressors-inotropes In Vasopressors Explained Clearly, renowned instructor Dr. Roger Seheult illustrates a concise way to understand vasopressors & inotropes, and how to systematically manage patients with hypotension & septic shock. 𝐂𝐨𝐦𝐩𝐥𝐞𝐭𝐞 𝐜𝐨𝐮𝐫𝐬𝐞 𝐢𝐧𝐜𝐥𝐮𝐝𝐞𝐬 𝐭𝐡𝐞 𝐟𝐨𝐥𝐥𝐨𝐰𝐢𝐧𝐠: - A thorough comparison of each vasopressor + key differences: levophed, epinephrine, vasopressin, neosynephrine, dopamine, dobutamine, etc. - Key physiology of endogenous vs. exogenous vasopressors - Illustrations of the receptors involved in mediating blood pressure - A systematic approach to managing hypotension and septic shock. - Side effects of vasopressors and inotropes - Central line vs. alternative options for administration. - A clinical perspective of tips, nuances, & practice scenarios. - Quiz questions to reinforce core concepts and help you study See how this course can help you excel at shock & hypotension management with a clear understanding of vasopressors: https://www.medcram.com/courses/vasopressors-inotropes 𝗛𝗶𝗴𝗵𝗹𝗶𝗴𝗵𝘁𝘀 𝗼𝗳 𝘁𝗵𝗶𝘀 𝘃𝗶𝗱𝗲𝗼 𝗶𝗻𝗰𝗹𝘂𝗱𝗲: - Core vasopressor physiology - The synthetic pathway for dopamine, norepinephrine, and epinephrine (includes tyrosine and L DOPA) - Vitamin C and the Marik Protocol - Limitations of studies that are not randomized, placebo-controlled Visit https://www.MedCram.com for this complete course and over 100 free lectures. This is the home for ALL MedCram.com medical videos (many medical videos, medical lectures, and quizzes are not on YouTube). Speaker: Roger Seheult, MD Co-Founder of MedCram.com (https://www.medcram.com) Clinical and Exam Preparation Instructor Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine. Visit https://www.MedCram.com for hundreds of clear & concise videos MedCram = MORE understanding in LESS time MedCram: Medical education topics explained clearly including: Respiratory lectures such as Asthma and COPD. Renal lectures on Acute Renal Failure and Adrenal Gland. Internal medicine videos on Oxygen Hemoglobin Dissociation Curve and Medical Acid Base. A growing library on critical care topics such as Shock, Diabetic Ketoacidosis (DKA), and Mechanical Ventilation. Cardiology videos on Hypertension, ECG / EKG Interpretation, and heart failure. VQ Mismatch and Hyponatremia lectures have been popular among medical students and physicians. The Pulmonary Function Tests (PFTs) videos and Ventilator-associated pneumonia bundles and lectures have been particularly popular with RTs. NPs and PAs have given great feedback on Pneumonia Treatment and Liver Function Tests among many others. Dr. Jacquet teaches our FAST exam tutorial & bedside ultrasound courses. Many nursing students have found the Asthma and shock lectures very helpful. We're starting a new course series on clinical ultrasound/ultrasound medical imaging. Recommended Audience - Medical professionals and medical students: including physicians, nurse practitioners, physician assistants, nurses, respiratory therapists, EMT and paramedics, and many others. Review and test prep for USMLE, MCAT, PANCE, NCLEX, NAPLEX, NBDE, RN, RT, MD, DO, PA, NP school and board examinations. More from MedCram.com medical lectures: Facebook: https://www.facebook.com/MedCram Google+: https://plus.google.com/u/1/+Medcram Twitter: https://twitter.com/MedCramVideos Subscribe to the official MedCram.com YouTube Channel: https://www.youtube.com/subscription_center?add_user=medcramvideos Produced by Kyle Allred PA-C Please note: MedCram medical videos, medical lectures, medical illustrations, and medical animations are for medical education and exam preparation purposes, and not intended to replace recommendations by your doctor or health care provider.
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L-tyrosine (also just called tyrosine) is a nootropic supplement that enhances your brain, mood, and stress response. Tyrosine is a precursor for three important neurotransmitters: dopamine, norepinephrine, and adrenaline. When stress depletes your neurotransmitter stores, tyrosine helps replenish them, allowing you to stay mentally sharp for longer, especially when you’re under pressure. L-tyrosine is also great for boosting mood. Studies show it helps with some types of depression. L-tyrosine is common in food, but to get its brain-boosting, stress-relieving benefits, you want purified tyrosine in supplement form. Listen to this audio article to learn the best dosage of L-Tyrosine and how it works to destress your world. Want to READ the article? Click Here: https://blog.bulletproof.com/l-tyrosine-supplement-benefits-dosage/ If you like this video, subscribe to Bulletproof on YouTube today, where you'll find full-length episodes of Bulletproof Radio to watch and listen to, interviews with thought leaders in mindfulness, health, nutrition, science, and biohacking. Also, one simple hack - Bulletproof Coffee - try making it at home - here's the recipe! https://blog.bulletproof.com/bulletproof-coffee-recipe/ Bulletproof Radio is one of the top ranked Podcasts on iTunes! You can subscribe by clicking here: https://itunes.apple.com/us/podcast/b... Connect with us on social media for quick updates and the newest biohacks: Facebook - https://www.facebook.com/bulletproof Twitter - @bpnutrition Pinterest - http://www.pinterest.com/bppins Instagram - www.instagram.com/bulletproof // instagram.com/dave.asprey
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Support us on Patreon: https://www.patreon.com/speedpharmacology Follow us on Facebook: https://www.facebook.com/SpeedPharmacology/ Get Speed Pharmacology Merch Here: https://teespring.com/stores/speed-pharmacology **************************************************************************************************** Topics covered include: mechanism of action of adrenergic agonists; catecholamines, noncatecholamines, direct acting, indirect acting, mixed action, alpha receptors, beta receptors. Adrenergic agonists mentioned include: epinephrine, norepinephrine, dopamine, oxymetazoline, phenylephrine, clonidine, dobutamine, albuterol, terbutaline, salmeterol, formoterol, mirabegron, cocaine, amphetamine, ephedrine, pseudoephedrine.
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Taurine is one of the non essential amino acids. This means that our body can make it on its own without needing to obtain it from other food sources. Taurine can be found in foods like meat and fish so if you are a vegetarian you may to supplement with this, but may not. Taurine has been found to be potentially beneficial for treatment of Cystic Fibrosis, liver disease, high blood pressure and high cholesterol.
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https://blackstonelabs.com/collections/all-supplements/products/anesthetized Making gains isn’t purely about lifting big and eating big, it’s also about sleeping big too! Far too often athletes train their tails off but don’t get enough sleep at night, and shortcut their growth potential, thereby limiting their results. Getting a full night’s sleep isn’t easy, which is why Blackstone Labs has created the ultimate formula to knock you out at night and keep you out until morning in Anesthetized. 1 scoop of this nighttime recovery and growth formula will have you sleeping like a baby and waking up in the morning ready for another day of crushing it in the gym! Gamma-Aminobutyric acid (3,00mg) GABA is the body’s primary inhibitory or “downer” neurotransmitter. Supplementing with GABA promotes the “deep relaxation” waves in the brain providing a more restful and restorative sleep. L-Taurine (2,200mg) a conditionally essential amino acid that reduces cortisol levels, thereby lowering stress, and increases production of GABA. Research demonstrates that taurine can bolster immune system function, insulin sensitivity, and cardiovascular health as well. Phenibut (1,800mg) is an extremely powerful anxiolytic and relaxation supplement. Phenibut easily crosses the blood-brain barrier where it exerts a tranquilizing effect by acting on the GABA receptors in your brain. With phenibut, you’re guaranteed a VERY deep sleep. N-Acetyl L-Tyrosine (500mg) increases levels of several important transmitters, including dopamine, shown to reduce stress. As you know, chronic stress makes quality sleep virtually impossible. N-Acetyl L-Tyrosine helps to lower stress and cortisol levels allowing for a more peaceful sleep at night. Valerian Root (250mg) encourages relaxation and sedation, hence why it’s commonly consumed in the form of tea prior to bedtime. Valerian helps you fall asleep quicker, allowing for greater recovery during the night. Mucuna Pruriens (100mg) also known as velvet bean, mucuna pruriens is loaded with L-Dopa, the precursor to dopamine. Research notes that supplementing with the plant reduces cortisol and prolactin levels and promotes greater growth hormone (GH) production. Taking mucuna before bed may promote a more restorative sleep, enhancing recovery and growth from intense training.
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https://www.nutrusta.com/products/ubiquinol-coq10 Try Nutrusta Ubiquinol Ultra brand Coenzyme Q10 supplement with better absorption, replaces 200, 300, 400, 600 mg. Amazon: https://www.amazon.com/Ubiquinol-CoQ10-VESIsorb-Kaneka-100mg/dp/B00KB2XSG0/ Today, we'll talk about the 4 Proven Benefits of CoQ10 and one BIG problem you should be aware of if you're planning to take or already take CoQ10 supplements. Coenzyme Q10 or CoQ10 is a fat-soluble compound found in virtually every cell membrane in the human body. It is most abundant in the heart, liver, kidneys and pancreas. CoQ10 exists in either Ubiquinone (the inactive form), or Ubiquinol (the active form). The body can synthesize its own CoQ10 from tyrosine or phenylalanine, aided by vitamin B6, but as we age (or take statin drugs), CoQ10 production decreases. CoQ10 has two main biochemical functions: CoQ10 is vital for energy production. It moves electrons in the mitochondria to enable life-sustaining biochemical reactions, specifically the conversion of glucose into ATP. CoQ10 as Ubiquinol is the most powerful fat-soluble antioxidant in the body. As a "reduced" compound, Ubiquinol either donates extra electrons to appease the free radicals that are trashing the body, or regenerate weakened antioxidants. Related video: ---------------------- https://www.youtube.com/watch?v=R0WNijKmJRs CoQ10 Could Reduce Blood Pressure CoQ10 supplementation could moderately lower systolic blood pressure by up to 17 points and diastolic blood pressure by up to 10 points in hypertensive individuals, perhaps by promoting vasodilatory actions of Nitric Oxide.1 It Supports Heart and Skeletal Muscles CoQ10 supplementation could significantly improve heart function and quality of life, as well as symptoms of heart failure like shortness of breath, fatigue and swelling, and even reduce deaths from adverse cardiac incidents.2-5 CoQ10 supplementation in heart attack survivors could improve heart function and exercise tolerance, and decrease chest pains and arrhythmias. Over the long-term CoQ10 supplementation may lower cardiac incidents and reduced rehospitalizations.6-8 In patients undergoing bypass and valve surgeries, pre-surgery CoQ10 supplementation could aid in recovery.9-11 People who are experiencing statin-related muscle weakness and pain may experience up to 50% improvement of symptoms with CoQ10 supplementation. CoQ10 May Restore Arterial Health CoQ10 supplementation may significantly improve endothelial function and restore normal blood flow in patients with atherosclerosis.12-16 Supplementation Improves Migraines CoQ10 supplementation could also significantly reduce duration, symptoms and frequency of migraine headaches.17-19 The BIG Problem Is... CoQ10 is lipophilic, insoluble in water, has limited solubility in lipids, and is a pretty large molecule. Because of its molecular structure, CoQ10 has notoriously poor absorption. When ingested as a supplement, as much as 60% of the dose will just bounce off the intestinal walls and end up in the toilet.20 THE NUTRUSTA SOLUTION Nutrusta Ubiquinol Ultra is a water-soluble formulation that combines the active, "body-ready" form of CoQ10 and the novel VESIsorb® micelle-based delivery system, clinically proven21 to ensure 6 times higher absorption and 3-fold increase in bioavailability for a maximum and sustained therapeutic levels of CoQ10 that supports heart function, energy production, and oxidant protection. All this in one 100 mg softgel capsule! Click on the link to start saving money with Nutrusta Ubiquinol Ultra today. * Individuals who are taking blood thinners are not recommended to take CoQ10 for possible drug interactions. Pregnant or lactating women are recommended to talk their doctor. **All material provided within this video is for informational and educational purposes only, and is not to be construed as medical advice or instruction. No action should be taken solely on the contents of this video. Playlist: https://www.youtube.com/playlist?list=PL5LPJTK5cMXTIPEzopEt6qmwuL206BUc8 SUPPORTING RESEARCH: 1. Burke BE, Neuenschwander R, Olson RD. Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension. South Med J. 2001;94(11):1112-1117. 2. Folkers K, Vadhanavikit S, Mortensen SA. Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme Q10. Proc Natl Acad Sci U S A. 1985;82(3):901-904. 3. Trupp RJ, Abraham WT. Congestive heart failure. In: Rakel RE, Bope ET,eds. Rakel: Conn's Current Therapy 2002. 54th ed. New York: W. B. Saunders Company; 2002:306-313. 4. Belardinelli R, Mucaj A, Lacalaprice F, et al. Coenzyme Q10 and exercise training in chronic heart failure. Eur Heart J. 2006; 27(22):2675-2681
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Subscribe for 3-4x Videos Per Week http://ThomasDeLauer.com Get Zevia HERE: https://www.zevia.com Click here to subscribe to my YouTube Channel: https://www.youtube.com/thetdelauer?sub_confirmation=1 Intermittent Fasting: Increase the Power of Your Fast with These 4 Drinks- Thomas DeLauer… Drinks: Apple Cider Vinegar + Lemon Coffee with Stevia Zevia (Soda & Sparkling Water) Green Tea with Ginseng Apple Cider Vinegar + Lemon: ACV- Halts the digestive process by inactivating the production of certain digestive enzymes responsible for digestion. Controls blood glucose levels and with a balanced blood sugar level, you're much less likely to experience intense, hard-to-resist sugar cravings throughout the day (1,2) Lemon- Lemons contain a soluble fiber known as pectin that benefits the body’s detoxifying capabilities by regulating the body’s use of sugars and cholesterol; improves gut and digestive health Coffee With Stevia: Caffeine- Caffeine acts on the central nervous system and causes a release of the neurotransmitters dopamine and epinephrine - increases thermogenesis and fat oxidation. In one study, twelve healthy, normal weight men participated in a four-way crossover, randomized, placebo-controlled, double-blind study. Treatments were administered as tablets of 500 mg Green Tea Extract, 400 mg tyrosine, 50 mg caffeine, or placebo. Results: Caffeine induced a thermogenic response of 6% above baseline compared to placebo and only caffeine was thermogenic in the given dose and caused no hemodynamic side effects Chlorogenic Acid (CGA)- Chlorogenic acid is a polyphenol antioxidant found in coffee - reduces blood glucose and insulin levels after a meal. Zevia- Zevia is an all-natural zero calorie soda made without artificial sweeteners, is non-GMO, kosher, gluten-free, vegan and contains no colors, dyes or phosphoric acid. Considered an all-natural alternative as it uses stevia, a herb from the sunflower family, as its sweetener and is up to 300x sweeter than sugar. Stevia- Lowers insulin and glucose due to its lack of metabolization - steviol glycosides pass through the upper gastrointestinal tract fully intact. Lowers Blood Pressure- One study from the journal Clinical Therapeutics conducted a randomized, double-blind, placebo-controlled trial in 174 patients - patients took either 500 mg of stevioside or placebo, 3 times per day. After two years, the group taking stevioside: Systolic blood pressure went from 150 to 140 mmHg and Diastolic blood pressure went from 95 down to 89 mmHg. Iced Green Tea with Extra Ginseng: Ginseng- Study/ The International Wound Journal found that ginseng supplementation increased the growth of wound-healing cells (fibroblasts) and increased collagen synthesis in human dermal cells. *This Video does contain a paid promotion from Zevia. They reached out to me and were excited to see me drink Zevia in a precious Instagram photo and asked if I would be open to sharing that I drink Zevia. References: 1) acetic acid | CH3COOH - PubChem. (n.d.). Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/acetic_acid 2) Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365176/ 3) The effect of caffeine, green tea and tyrosine on thermogenesis and energy intake. - PubMed - NCBI. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/17882140 4) Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea | Regulatory, Integrative and Comparative Physiology. (n.d.). Retrieved from http://ajpregu.physiology.org/content/292/1/R77 5) Roles of Chlorogenic Acid on Regulating Glucose and Lipids Metabolism: A Review. (n.d.). Retrieved from https://www.hindawi.com/journals/ecam/2013/801457/ 6) Hsieh MH , et al. (n.d.). Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled study. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/14693305 7) MS, M. (n.d.). Influence of calcium on the blood pressure and renal effects of stevioside. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/1342842 8) Bitter stimuli induce Ca2+ signaling and CCK release in enteroendocrine STC-1 cells: role of L-type voltage-sensitive Ca2+ channels. http://ajpcell.physiology.org/content/291/4/C726 9) Green tea extract thermogenesis-induced weight loss by epigallocatechin gallate inhibition of catechol-O-methyltransferase. - PubMed - NCBI. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/17201629 10) How Green Tea Can Help You Lose Weight Naturally. (n.d.). Retrieved from http://www.healthline.com/nutrition/green-tea-and-weight-loss#section3 11) 15 Health Benefits of Ginseng - Selfhacked. (2017, October 24). Retrieved from https://selfhacked.com/blog/ginseng/
Просмотров: 664425 Thomas DeLauer
Visit https://getroman.com/alpha NOW and get your first month of care for FREE! Special alpha m. thank you to Roman for helping guys deal with a very tough topic and giving them a "solid" solution! Also, thank you for sponsoring this important video! Use Code: INSTANT25 for 25% off your 1st system http://tiege.com/instant25 & GET HANDSOME TODAY! 7 Daily Habits That Will Make You Better Looking: https://youtu.be/NpK2hRPaMZE Stubble Sexiness Study: https://medicalxpress.com/news/2013-04-men-heavy-stubble.html Use Code: HAIRAWARDS25 for 25% Off your ENTIRE Order http://peteandpedro.com Salt: https://peteandpedro.com/collections/bueno_hair_products/products/salt Putty: https://peteandpedro.com/collections/bueno_hair_products/products/putty All promotion and advertising inquiries: Terry@MENfluential.com Check out my NEW website: http://www.alpham.com The BEST Hair Styling Products http://www.peteandpedro.com All Things Alpha M. http://www.alpham.com Pete & Pedro: http://www.peteandpedro.com My Website: http://www.iamalpham.com My Services and Products: http://www.aaronmarino.com Best Hair Product: http://www.peteandpedro.com Tiege Hanley Skin Care: http://www.tiege.com Best Grooming Tool: http://bit.ly/2tiyTXO Alpha M. App: http://www.alphamapp.com/ Best Hair Product: http://www.peteandpedro.com Free Hairstyle E-Book: http://www.iamalpham.com/ezine FaceBook: https://www.facebook.com/IAmAlphaM Twitter: https://twitter.com/IAmAlphaM Instagram: https://www.instagram.com/aaronmarino/ My Businesses: http://www.alpham.com Alpha M. Consulting: http://www.aaronmarino.com i am alpha m: http://www.iamalpham.com Pete & Pedro: http://www.peteandpedro.com MENfluential Media: http://www.menfluential.com MENfluential Conference: http://menfluentialconference.com/ Tiege Hanley: http://tiege.com The other day, Alpha read a MIND BLOWING stastic: 52% of all men experience some degree of erectile dysfunction (ED), which 26% are UNDER 40 years old! So, 1 in 4 guys under 40 will have trouble at some point! ED is a huge issue! In this video men's style, grooming, fitness and lifestyle expert, Aaron Marino of IAmAlphaM, AaronMarino, and Pete & Pedro is discussing ED and why it happens, what to do about it, and how to fix it. What constitutes ED? trouble getting it up trouble keeping it up decreased sexual desire Why does ED (aka impotence) happen? What are the causes? Physical issues that can cause ED include heart disease, high blood pressure, high cholesterol, diabetes, obesity, tobacco, some medications, Parkinson's disease, alcohol, sleep disorders, enlarged prostate, and treatment of prostate cancers. Emotional or physiological issues that can cause ED include depression, anxiety, stress, and relationship issues. While treating the cause, treat the symptoms Obtain a diagnosis and treatment from a physician. You can treat the symptoms while treating the cause; however, searching online is dangerous as 80% of Viagra is counterfeit. And unfortunately, 75% of guys don't do anything at all. You deserve to be happy, have sex, and have sexual gratification. Remember, you're not alone. It's nothing to be ashamed about either. Fix it, and while doing so, treat the symptoms. Here's how: GetRoman.com Visit https://getroman.com/alpha NOW and get your first month of care for FREE! GetRoman.com is a company whose goal is to provide the safest, easiest, and most affordable way to treat ED. It's convenient and discrete too with prices cheaper than your physician and pharmacy for the same medications. With GetRoman.com, you submit your information which a doctor subsequently reviews to determine if you're a candidate. Thereafter, they offer a variety of treatment plans. Member support is available 365 days a year too. With their special deal with Alpha, you can get the 1st month free with the link Get Roman | 1st Month FREE
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In this video you'll discover the nootropics benefits of Berberine. Including which types of Berberine make the best nootropic, recommended dosage, side effects and clinical research. Berberine is well known and proven for reversing type-2 diabetes. But few people realize how powerful this supplement can be for reducing sugar cravings, eliminating late afternoon energy crashes, lifting brain fog, and boosting memory and mood. Berberine activates the enzyme AMPK which is the master metabolic switch in each one of your cells. This directly influences lipid, glucose and energy imbalances. Activating AMPK by adding Berberine to your nootropic stack boosts mental energy, provides quicker thinking, and even repairs and maintains healthy brain cells. Berberine also inhibits acetylcholinesterase (AChE) activity in your brain. Increasing levels of acetylcholine has a direct influence on concentration, focus and memory. Berberine is at least as effective in controlling blood sugar and insulin sensitivity as metformin. The latest research confirms user experience that supplementing with Berberine can help with depression, help prevent Alzheimer's, help control several types of cancer, lower cholesterol and blood pressure, and help with weight loss. This indepth Berberine review covers: 00:26 Berberine as a nootropic 04:23 How does Berberine work in the brain? 07:13 Why you need Berberine 08:38 Berberine benefits 10:22 How does Berberine feel when you take it as a supplement? 12:07 Berberine Clinical Research 14:39 Recommended dosage for Berberine 16:23 Berberine side effects 18:20 Types of Berberine supplements to buy For more on Berberine including a full transcript of this video and links to clinical studies, go to: http://nootropicsexpert.com/berberine/ For a full list of all the popular nootropics used today, go to: http://nootropicsexpert.com/nootropics-list/ I upload new videos every week providing individual nootropic reviews, and tips on the best nootropic stacks no matter what your brain optimization goals. For a list of all the videos I have so far, go to my channel: https://www.youtube.com/c/nootropicsexpert
Просмотров: 15848 NootropicsExpert
Get it here: http://www.bulletproof.com/l-tyrosine-60-count How well do you think and act under pressure? Bulletproof™ L-Tyrosine supports your mood and resiliency to stress with an amino acid that quickly crosses the blood-brain barrier — helping with the production of the neurotransmitters dopamine, epinephrine, and norepinephrine. Dopamine is commonly known as the “feel good” neurotransmitter, and it’s responsible for the happy feeling we get from experiences like sex, hugs, and rock n’ roll. It also helps to keep your brain from overheating during strenuous physical activities. Meanwhile, epinephrine and norepinephrine function in the brain and body as both neurotransmitters and hormones, and they’re critical in your response to physical and mental stress.
Просмотров: 6403 Bulletproof
A clinically research, all-in-one solution for instantly increasing your energy levels: 👉 http://drsam.co/yt/EnergyBoost Or go and watch this: How to sleep less and have more energy: https://www.youtube.com/watch?v=qB4H3QuVpMo References 1. Comp Biochem Physiol Part D Genomics Proteomics. 2012 Jun;7(2):161-71. 2. Science. 2010 Dec 3;330(6009):1349-54. 3. J Clin Sleep Med. 2007 Dec 15;3(7):681-8 4. http://www.stress.org/americas-1-health-problem/ Accessed January 7, 2013 5. Nat Rev Neurosci. 2009;10(3):199-210. 6. Obes Rev. 2009 Nov;10 Suppl 2:37-45. 7. Science. 2010 Dec 3;330(6009):1349-54 8. Phosphatidylserine: Number One Brain Booster. New Canaan, CT: Keats Plishing; 1998. 9. Neurobiol Aging. 2001 Jan-Feb;22(1):9-15. 10. J Int Soc Sports Nutr. 2008 Jul 28;5:11. ======================================= ======================================= Last week my niece stayed with me for a couple of days for some work related stuff. Every time I saw her, she said how “tired” she was - this included first thing in the morning. I said to her “you’re only 20 years old, why are you always so tired?!!” She replied and said “I know… I’m just so stressed all the time with work, school and life”. I didn’t say anything, but I was thinking “well, it’s only going to get worse as you get older because you’ll have a lot more responsibilities later on in life”. And then I was thinking how most people’s complaints, regardless of their age or sex, is being fatigued and tired And how most of the cause is due to “being stressed”. And as the saying goes, “stress kills”... And it really does because it causes lots of negative hormonal changes in your body. So today I’m going to reveal the 4 most powerful and clinically proven ingredients that will help - increase your energy - improve your memory and focus - while reducing your stress at the same time. … So the reason stress is bad is because it disrupts multiple biochemical pathways: including cortisol production (a primary stress hormone) adrenal production (a primary cause of fatigue) pro-inflammatory enzyme production (a primary cause of disease) and neurotransmitter production (a primary cause of brain aging).1-3 Sadly, an estimated 80%–90% of visits to primary care physicians are now related to the effects of stress.4 You may not be able to stop stress, but for longevity and health reasons, you need to give your body specific nutrients to help manage and reduce "stress side-effects". This way you’ll have more energy, improve your mind and memory, sleep better and look younger! So here are the 4 clinically proven ingredients: 1- Bacopa extract (50% bacopa glycosides) is traditionally used to help support memory and concentration while easing stress and tension. It is thought to help nourish neurons while restoring depleted synaptic activity and is one of the most revered herbs for brain health 2- Sensoril® Ashwagandha extract counters some of the oxidative damage generated by nervous tension and stress.5 Clinical trials have shown a 26% reducing of the stress hormone, cortisol …. while also improving blood sugar levels and lipid profiles.6 Studies have also shown an improvement in energy, sleep, healthy outlook and well-being, as well as diminished fatigue.7 3 - Sharp-PS® Green Phosphatidylserine (Soy Free) is required for normal cellular structure and function. Brain tissues are especially rich in phosphatidylserine (PS), but aging causes a decline in the PS content of cells throughout the body. Research has shown that in addition to improving neural function, PS enhances energy metabolism in all cells, memory, concentration, learning and word choice.8,9 Another major benefit to using PS is that it significantly modulates cortisol levels, resulting in a more relaxed state.10 4 - N-Acetyl Tyrosine is an amino acid that can be converted in the brain and in the adrenal glands to dopamine, norepinephrine, and epinephrine (adrenaline) hormones that are depleted by stress, overwork and certain drugs. By replenishing norepinephrine in the brain, mental energy levels will be improved. Also, the N-Acetyl version of Tyrosine is more stable and soluble, thus resulting in greater bioavailability and effectiveness. … so these are the 4 best ingredients for reducing your stress hormones, resulting in higher energy levels. Now, there are a few other very important, clinically proven and safe ingredients that will dramatically increase full-body energy levels -- both your body AND brain. ======================================== Thank you for watching. Please feel free to comment, like or share with your friends. Subscribe to Dr.Sam Robbins's official Youtube channel http://drsam.co/yt/subscribe Like us on Facebook https://www.facebook.com/DrSamRobbins Visit Dr.Sam Robbins's blog for more information on your health! http://www.drsamrobbins.com/ ======================================== Thanks DrSamRobbins
Просмотров: 12878 Dr Sam Robbins
FREE Keto mini-course delivered to your messenger: http://pxlme.me/HnHLd5z5 Take Dr. Berg's Body Type Quiz: http://bit.ly/BodyTypeQuiz If you would like an online or in-house health evaluation call 703-354-7336. https://drberg.com/body-type-quiz1?ut... Dr. Berg discourages smoking and shares some tips to quit smoking. The best way to quit smoking is do it gradually. He talks about side effects of quitting smoking and other ways to stop smoking without causing harm to the body. The best way to quit smoking is to build up the raw materials for the neurotransmitters. Nicotine triggers certain neurotransmitters, which vasodilate the coronary artery and the bronchial tubes, which give you a sense of stress relief, but in reality, it's just the opposite, especially over time. Dr. Berg recommends making the transition with added amino acids so as to build up the neurotransmitters and support the adrenal glands. *Phenylalanine *Tryrosine *L-dopa *B-vitamins (Nutritional Yeast) For more information about Dr. Berg's program in Alexandria, Virginia, call 703-354-7336. DR. BERG'S VIDEO BLOG: http://www.drberg.com/blog FACEBOOK: http://www.facebook.com/DrEricBergDC TWITTER: http://twitter.com/DrBergDC YOUTUBE: https://www.youtube.com/user/drericbe... ABOUT DR. BERG: http://www.drberg.com/dr-eric-berg/bio DR. BERG'S SEMINARS: http://www.drberg.com/seminars DR. BERG'S STORY: http://www.drberg.com/dr-eric-berg/story DR. BERG'S CLINIC: https://www.drberg.com/dr-eric-berg/c... DR. BERG'S HEALTH COACHING TRAINING: http://www.drberg.com/weight-loss-coach DR. BERG'S SHOP: http://shop.drberg.com/ DR. BERG'S REVIEWS: http://www.drberg.com/reviews The Health & Wellness Center 4709 D Pinecrest Office Park Drive Alexandria, VA 22312 703-354-7336 Disclaimer: Dr. Eric Berg received his Doctor of Chiropractic degree from Palmer College of Chiropractic in 1988. His use of “doctor” or “Dr.” in relation to himself solely refers to that degree. Dr. Berg is a licensed chiropractor in Virginia, California, and Louisiana, but he no longer practices chiropractic in any state and does not see patients. This video is for general informational purposes only. It should not be used to self-diagnose and it is not a substitute for a medical exam, cure, treatment, diagnosis, and prescription or recommendation. It does not create a doctor-patient relationship between Dr. Berg and you. You should not make any change in your health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis, and recommendation. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. The Health & Wellness, Dr. Berg Nutritionals and Dr. Eric Berg, D.C. are not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this video or site.
Просмотров: 619903 Dr. Eric Berg DC
An “all-in-one” formula for instantly increasing your energy levels and improving memory naturally: 🤜 http://drsam.co/yt/BoostYourEnergy ======================================= ☕ The Major Health Problem With Energy Drinks and Caffeine ======================================= Unfortunately, Energy Drinks Are HORRIBLE For Your Health Do they taste good? Yes… but that’s because they either have lots of sugar (over 60 grams and 250 calories worth). Or the sugar-free ones are loaded with toxic artificial sweeteners. Are they healthy for you? Nope! Just because they contain a few vitamins, doesn’t mean they are healthy. Secondly, they make your body very acidic which is known to cause cancer and accelerate aging.9 Energy drinks are linked to many health problems, but these are the big ones in my opinion: Heart problems — cardiac arrest1, high blood pressure2, decreased arterial health1 and more. Physical problems — headaches, migraines, insomnia5, arthritis3, addictive, type 2 diabetes6, erectile dysfunction and poor blood flow11. Emotional problems — anxiety, panic attacks, nervousness, and depression.7 Do they give you energy? Yes they do, but that’s because of the massive dose of CAFFEINE they contain! That’s 3-4 cups of strong coffee. Trust me, take out the caffeine and there is no “energy” in these drinks. As you can see, there are lots of problems with energy drinks, but … The WORST Problem Of All The WORST problem with energy drinks is the caffeine consumption and the negative change in your hormones due to the RISE in your “stress hormone” called, cortisol! The elevation in this stress hormone is the cause of many of the above mentioned negative effects. Why We Like Caffeine So Much So, why do you or anyone even take caffeine products?… You can have “decaf” coffee, tea or energy drinks. It tastes the same. At the end of the day, it’s simply because you like how the caffeine makes you FEEL. After all, it IS a drug! We like the temporary extra energy levels — both physical and mental. Additionally, caffeine temporarily increases dopamine levels slightly. Dopamine is known as the “pleasure chemical”. So, another reason caffeine makes us “happy”. However, after continued use (usually 7-10 days): -your adrenal glands become overworked, -cortisol levels increase, -dopamine receptors become desensitized -and caffeine is NO LONGER making you “energized and happy”… Many times you have mid-day “caffeine crash”, which means MORE caffeine (coffee, energy drinks, etc.). Thus, why it’s addictive. And when you get off, the opposite happens — you’re super tired, anxious and depressed! How To Increase Your Energy Levels & Feel Good, WITHOUT Caffeine! The good news is that with the correct combination of natural ingredients, you’ll get MANY MORE BENEFITS. When increasing your energy levels – you want to focus on BOTH physical and mental energy. Increase ATP & Mitochondria A common complaint among people, especially older adults is the loss of physical and mental energy. You can naturally increase these by taking Rhodiola Extract, NADH, CoQ10, PQQ and Acetyl-L-Carnitine. Improve Dopamine This is a neurotransmitter that regulates your mood and cognition/memory. It’s known as the anti-aging “pleasure chemical”. It gives you a natural “high”. You can naturally increase dopamine by using wild green oat extract, velvet bean extracts and L-Theanine Decrease Stress Hormones As stated earlier, caffeine increases (NOT what you want) your stress hormones and depletes your adrenal glands, which leads to fatigue, weight gain and depression. You can naturally decrease stress hormones and improve your memory by taking Bacopa and Ashwagandha extract, Phosphyatidylserine and Tyrosine. Increase Acetylcholine & Oxygen Proper acetylcholine function is essential to muscle control, sleep, and cognition… and the prevention of dementia, Alzheimer’s and Parkinson’s disease.12 Additionally, increasing oxygen to your cells – both brain and muscle, will dramatically increase your energy levels and slow the aging process.13-16 To increase acetylcholine – you can take Alpha-GPC, Choline and Huperzine-A. And to improve oxygen to your cells, you should take Ginkgo Biloba and Vinpocetine. Total Body & Brain Energy Remember, your goal is to increase your energy levels to BOTH your body (muscles) and brain (neurotransmitters), while reducing the aging process at the same time. ======================================== Thank you for watching. Please feel free to comment, like or share with your friends. Subscribe to Dr.Sam Robbins's official Youtube channel http://drsam.co/yt/subscribe Like us on Facebook https://www.facebook.com/DrSamRobbins Visit Dr.Sam Robbins's blog for more information on your health! http://www.drsamrobbins.com/ ======================================== Thanks DrSamRobbins
Просмотров: 12570 Dr Sam Robbins
Get Dr. Berg's New Electrolyte Powder: http://bit.ly/Electrolyte-Powder-1 (use this code: IK7H05 to get 10% off) Take Dr. Berg's Advanced Evaluation Quiz: http://bit.ly/EvalQuiz Your report will then be sent via email analyzing 104 potential symptoms, giving you a much deeper insight into the cause-effect relationship of your body issues. It's free and very enlightening. Heartburn video (low acids): https://www.youtube.com/watch?v=SWvvn... https://www.youtube.com/watch?v=aBV0T... Insulin Resistance & Potassium: https://www.youtube.com/watch?v=z1AOt... Dr. Berg talks about restless legs syndrome (RLS) and what to do about it. There are 2 main causes, one is a vitamin B1 deficiency due to lactic acidosis, and the second cause being a potassium deficiency. Dr. Berg then talks about insulin resistance and how this alone will keep your potassium from being absorbed. So the cause may be dietary but it may be an insulin problem. The other problem is stomach acid - if you do not have the acid in your stomach, you will not be able to absorb potassium from that alone. Potassium Citrate is a good remedy. Dr. Eric Berg DC Bio: Dr. Berg, 51 years of age is a chiropractor who specializes in weight loss through nutritional and natural methods. His private practice is located in Alexandria, Virginia. His clients include senior officials in the U.S. government and the Justice Department, ambassadors, medical doctors, high-level executives of prominent corporations, scientists, engineers, professors, and other clients from all walks of life. He is the author of The 7 Principles of Fat Burning, published by KB Publishing in January 2011. Dr. Berg trains chiropractors, physicians and allied healthcare practitioners in his methods, and to date he has trained over 2,500 healthcare professionals. He has been an active member of the Endocrinology Society, and has worked as a past part-time adjunct professor at Howard University. DR. BERG'S VIDEO BLOG: http://www.drberg.com/blog FACEBOOK: http://www.facebook.com/DrEricBerg TWITTER: http://twitter.com/DrBergDC YOUTUBE: https://www.youtube.com/user/drericbe... ABOUT DR. BERG: http://www.drberg.com/dr-eric-berg/bio DR. BERG'S SEMINARS: http://www.drberg.com/seminars DR. BERG'S STORY: http://www.drberg.com/dr-eric-berg/story DR. BERG'S CLINIC: https://www.drberg.com/dr-eric-berg/c... DR. BERG'S HEALTH COACHING TRAINING: http://www.drberg.com/weight-loss-coach DR. BERG'S SHOP: http://shop.drberg.com/ DR. BERG'S REVIEWS: http://www.drberg.com/reviews The Health & Wellness Center 4709 D Pinecrest Office Park Drive Alexandria, VA 22312 703-354-7336 Disclaimer: Dr. Eric Berg received his Doctor of Chiropractic degree from Palmer College of Chiropractic in 1988. His use of “doctor” or “Dr.” in relation to himself solely refers to that degree. Dr. Berg is a licensed chiropractor in Virginia, California, and Louisiana, but he no longer practices chiropractic in any state and does not see patients. This video is for general informational purposes only. It should not be used to self-diagnose and it is not a substitute for a medical exam, cure, treatment, diagnosis, and prescription or recommendation. It does not create a doctor-patient relationship between Dr. Berg and you. You should not make any change in your health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis, and recommendation. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. The Health & Wellness, Dr. Berg Nutritionals and Dr. Eric Berg, D.C. are not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this video or site.
Просмотров: 290995 Dr. Eric Berg DC
Get the nootropic starter pack here: https://www.livecortex.com/product/nootropics-starter-pack/ Get Nootropic stacks for the business professional here: https://www.livecortex.com/product/nootropic-stacks-for-the-business-professional/ Get the Noopept/Racetam 147 stack list here: https://www.livecortex.com/product/the-racetam-and-noopept-nootropic-mega-stack-list-combo/ Get the Cortex nootropic stack here: https://www.livecortex.com/cortex-generation1-nootropic/ Get the Noopept Pro Stack List here: https://www.livecortex.com/the-noopept-pro-stack-list-nootropics-bookguide/ Get Smarter Better Faster here: https://www.livecortex.com/smarter-better-faster-nootropics-ebook/ Get the Racetam God Guide here: https://www.livecortex.com/racetam-god-guide-nootropics-ebook/ Get Nootropic stack consulting here: https://www.livecortex.com/brain-performance-consulting-for-entrepreneursexecutives/
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Special Limited Offer for Bone Broth Here: http://bit.ly/2xlzyJz COUPON CODE: THOMAS20 for 20% off! Please Subscribe for 3x Videos Per Week + Live Broadcasts! http://ThomasDeLauer.com Training While Fasting: How to Avoid Insulin Resistance- Thomas DeLauer… Insulin Overview: Insulin is a hormone made in the pancreas and the pancreas contains groups of cells called islets - Beta cells within the islets make insulin and release it into the blood. Insulin plays a major role in metabolism - The digestive tract breaks down carbs into glucose. Insulin helps cells throughout the body absorb glucose and use it for energy. Insulin helps muscle, fat, and liver cells absorb glucose from the bloodstream, lowering blood glucose levels. Glucose levels are tightly controlled by insulin so that the rate of glucose production by the liver is matched by the rate of use by the cells. Insulin helps muscle, fat, and liver cells absorb glucose from the bloodstream, lowering blood glucose levels (allows glucose, amino acids, and creatine to enter the muscles) Insulin stimulates the liver and muscle tissue to store excess glucose (1) Insulin Resistance: In insulin resistance, muscle, fat and liver cells do not respond properly to insulin and cannot easily absorb glucose from the bloodstream - the body has to produce higher amounts to keep the blood glucose levels within a normal range. In other words, a person's body won’t be producing enough insulin to meet their needs because the body’s cells have become resistant to insulin. The cells aren’t as responsive to insulin and don’t “allow” enough glucose from the blood into the cells - Glucose remains in the bloodstream, causing high blood glucose levels. Study: A study published in the Journal of Diabetes and its Complications looked at the prevalence of insulin resistance in the United States during the periods 1988 -1994 and 1999-2002 - Found that 32.2% of the US population may be insulin resistant. Main Cause of Insulin Resistance: Insulin is released when the body has just been fed, which halts the body's burning of stored fat - also works on fat cells similar to how it works on muscle cells, opens them up for storage. This may be caused by fatty acid metabolites building up inside muscle cells, termed “intramyocellular fat” that disrupts the signaling pathways needed for insulin to work. Insulin is closely associated with obesity and weight gain, but it can also result in prediabetes and type 2 diabetes. (3) Insulin Sensitivity: When insulin is lowered, your body does not get the message to replenish fat and glycogen - means you are insulin sensitive and your body only requires a small amount of insulin in order to deposit glucose to your cells. Not only does insulin sensitivity promote weight loss, it also promotes healthy brain, artery, and pancreatic cells as they are no longer exposed to high levels of blood sugar for an elongated period of time. High blood pressure (which can result from insulin resistance) puts strain on your heart, increasing your risk of angina, hypertension, coronary artery disease, heart attack and heart failure. Ways to Reduce Insulin Resistance: - Lower your caloric intake (and carbs) - Exercise that burns glycogen and leaves your muscles empty (fasted training a +) - I.F. and Ketosis Magnesium: Magnesium improve and helps correct insulin sensitivity because an intracellular enzyme, called tyrosine kinase, requires magnesium to allow insulin to exert its blood-sugar-lowering effects. Study measured magnesium effects in non-diabetics with metabolic syndrome. Doctors followed 234 participants with three of five metabolic syndrome symptoms; abdominal obesity, high blood pressure or high fasting blood sugar, high triglycerides or low levels of HDL. After 12 months, only one in four met the recommended daily allowance for magnesium which ranges from 320 mg to 420 mg per day. Compared to those who got the least, those who got the most magnesium were 71 percent less likely to have insulin resistance. References: 1) Prediabetes & Insulin Resistance | NIDDK. (n.d.). Retrieved from https://www.niddk.nih.gov/health-information/diabetes/overview/what-is-diabetes/prediabetes-insulin-resistance 2) Prevalence and trends of insulin resistance, impaired fasting glucose, and diabetes. - PubMed - NCBI. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/17967708 3) Insulin and Insulin Resistance - The Ultimate Guide. (n.d.). Retrieved from http://www.healthline.com/nutrition/insulin-and-insulin-resistance 4) Magnesium improved insulin sensitivity - Nutrition Express Articles. (n.d.). Retrieved from https://www.nutritionexpress.com/article+index/vitamins+supplements+a-z/magnesium/showarticle.aspx?id=2029 5) Reversing Insulin Resistance - The Insulin Magnesium Story. (n.d.). Retrieved from http://drsircus.com/diabetes/reversing-insulin-resistance-the-insulin-magnesium-story/
Просмотров: 299214 Thomas DeLauer
For more info: https://draxe.com/natural-remedies-for-thyroid/?utm_campaign=Youtube-Mar-2015&utm_medium=social&utm_source=youtube&utm_term=thyroid In today’s video, I’m going to share with you my natural remedies for thyroid health. There are more people than ever before that are struggling with conditions like hypothyroidism, Hashimoto's disease, hyperthyroidism, and Graves' disease. If you have a sluggish thyroid or metabolism, this is a big warning sign that you may have a thyroid issue. My top five natural remedies that are safe, healthy, and effective for improving thyroid health are: 1. Ashwagandha 2. Selenium 3. B Vitamins (Thiamine and Vitamin B12) 4. Live Probiotics 5. Proteolytic Enzymes Following these five natural remedies are going to improve your thyroid health and adrenal gland function. For more information on conditions like hypothyroidism, check out: http://draxe.com/hypothyroidism-diet-natural-treatment/ *This content is strictly the opinion of Dr. Josh Axe, and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. Axe nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.
Просмотров: 320721 Dr. Josh Axe
Ana u periodu 4-13 meseci. Simptomi koji ukazuju na deficit tirozin hidroksilaze, pre utvrđene dijagnoze i pre terapije. Ana 4-13 months old. Symptoms of Tyrosine Hydroxylase Deficiency, before she was diagnosed with THD and before the l-dopa treatment. Tyrosine Hydroxylase deficiency, also known as Recessive Dopa-Responsive Dystonia, is a rare metabolic disorder characterized by the lack of the enzyme involved in converting the amino acid tyrosine to Ldopa. Patients with TH Deficiency can develop movement disorders, autonomic symptoms: blood pressure instability, temperature irregularities... abnormal eye movements and neurological impairment. In the mildest cases, walking or running may be clumsy but little else may be noticed initially. Symptoms may progress slowly as the child gets older. One side of the body may seem weaker, or the child may begin to walk up on their tiptoes due to some tightness of the leg muscles. Attention difficulties in school are common. Children with mild symptoms are often treated successfully with medication. In moderately affected cases, the child may not be able to walk at all, or walking may be extremely difficult. Unusual arm posturing or positions of their arms with attempts to walk or walk on their toes is common. Abnormal eye movements, tremor and speech delay may be present. Children with moderate symptoms often respond well to treatment but full benefit may take many months. In the most severe cases children are physically disabled and affected from early infancy. This is sometimes known as the Infantile Parkinson’s disease variant. Patients may demonstrate all or some of the following symptoms; - Muscle tightness: rigidity, spasticity - Abnormal posturing: arching of the back - Tremor - Poor muscle control - Abnormal eye movements: eye deviation upward, downward or towards the nose - Strabismus: cross-eyed - Ptosis-droopiness of the eyelids - Speech delay - Difficulties feeding or swallowing - Constipation - Torticollis-involuntary deviation of the head and neck - Intermittent color changes - Unexplained low body temperatures or fevers - Low blood sugar - Difficulty regulating blood pressure Children with TH Deficiency are often considered clumsy or uncoordinated and are often initially diagnosed with cerebral palsy.
Просмотров: 128564 Ivana Badnjarevic
Today I want to do a review of my favorite current nootropic of 2017 L-Theanine. I have been taking L Theanine for years in different products, then I started using L theanine by itself to see exactly how it works.. It is my highest recommended individual product for Anxiety / Mood Boosting! I would love to see what you guys think! L Theanine 200mg Capsules - http://amzn.to/2i2VpQX L Theanine Bulk Powder - http://amzn.to/2A4yZW2 From lifeextension.com L-theanine relieves anxiety in large part because it bears a close resemblance to the brain-signaling chemical glutamate. L-theanine produces the opposite effect in the brain. While glutamate is the brain’s most important excitatory neurotransmitter, L-theanine binds to the same brain cell receptors and blocks them to glutamate’s effects. This action produces inhibitory effects.1,2 That inhibition to brain overactivity has a calming, relaxing effect in which anxiety fades.3 In addition to blocking excitatory stimuli at glutamate receptors in the brain, L-theanine also stimulates production of the inhibitory, relaxing neurotransmitter GABA, adding to its calming, anti-anxiety effects.2 Unlike prescription anti-anxiety drugs, however, some of which mimic GABA’s effects, L-theanine produces its anti-anxiety effects without producing sleepiness or impairing motor behavior.4 In fact, L-theanine has been shown in human studies to moderately improve alertness and attention while exerting its anxiety-reducing effects.5 Of particular interest are studies showing that L-theanine supplementation prevents the abrupt rise in blood pressure that some people experience under stress.1 The reason this is so critical is that many people have normal blood pressure readings at rest that spike up to dangerously high levels when subjected to stressful situations. These periods of surging blood pressure inflict massive arterial damage and are the main reason why at-home and at-office blood pressure testing are so important.
Просмотров: 3409 RealJoshTv
http://articles.mercola.com/sites/articles/archive/2015/10/28/how-thyroid-gland-functions.aspx?x_cid=youtube Internationally renowned natural health physician and Mercola.com founder Dr. Joseph Mercola talks about thyroid and the symptoms and treatments of hypothyroidism.
Просмотров: 155513 Mercola
💪⚡ Try Online Counseling: http://tryonlinetherapy.com/speedpharmacology If you are struggling with depression or any other mental illness consider online counseling with a licensed professional at BetterHelp. It’s far cheaper and more convenient than in-person counseling. Believe me, you are worth it. By using my referral link, you support this channel. Support us on Patreon: https://www.patreon.com/speedpharmacology Follow us on Facebook: https://www.facebook.com/SpeedPharmacology/ Get Speed Pharmacology Merch Here: https://teespring.com/stores/speed-pharmacology **************************************************************************************************** Topics covered in this video include: monoamine hypothesis of depression, bipolar disorder, serotonin, norepinephrine, dopamine, receptors, mechanism of action of antidepressants; selective serotonin reuptake inhibitors, serotonin norepinephrine reuptake inhibitors ,tricyclic antidepressants, monoamine oxidase inhibitors, atypical antidepressants, and lithium. Antidepressants mentioned include: Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Venlafaxine, Desvenlafaxine, Duloxetine, Levomilnacipran, Amitriptyline, Amoxapine, Clomipramine, Desipramine, Doxepin, Imipramine, Maprotiline, Nortriptyline, Protriptyline, Isocarboxazid, Phenelzine, Tranylcypromine, Selegiline, Bupropion, Mirtazapine, Trazodone, Nefazodone, Vilazodone, and Vortioxetine.
Просмотров: 345098 Speed Pharmacology
https://livecortex.com - Cortex, a nootropic product for elite achievers, that facilitates focus, brain energy, memory, and verbal fluency.
Просмотров: 62694 Cortex Labs Nootropics Channel
How To Cure Hypothyroidism http://www.HypothyroidRevolution.org In alternative medicine, there is very little difference in curing hypothyroidism and hyperthyroidism. This is because the treatment involves assisting the thyroid to heal, in either case. Those with hyperthyroidism should not use iodine, because it could overdrive the thyroid, worsening the condition. Curing thyroid disease requires a long-term commitment for a period of at least a year. Creating this problem took years of self-poisoning, so fixing it is neither quick, nor easy. Hypothyroidism medications are addictive, and the body becomes reliant on them, which is why the mainstream establishment maintains that people must take them forever. Those who have been taking hypothyroidism medications for years must slowly wean themselves from the drugs. Abruptly stopping these medications will result in extreme fatigue, and additional thyroid problems. Treatment Recommendations Eliminate and discard all non-stick cookware Eliminate Soy - Soy suppresses thyroid function, imbalances hormones, and it has been shown to cause goiters (an enlargement of the thyroid gland) in previously healthy individuals, which shows that it disrupts iodine usage. Adhere to an Alkaline Diet - This is extremely helpful when curing any chronic disease. Reference the Body pH and Disease article to guide you. Balance Estrogen Levels (Women) - Excess estrogen slows down the thyroid gland. This means eliminating birth control medications, increasing the fiber in the diet, and avoiding all non-organic meats. Growth hormones in meats lead to imbalanced hormones. Reduce dairy intake, because milk often contains lots of estrogen; primarily because cows are milked frequently during pregnancy. Exercise - Find a physical activity that is fun, and do it often. We believe that exercise could half the cure time in some cases, and curing is not possible without it. Hemp Fiber - This is a broad spectrum supplement and a mild laxative. L-Tyrosine - Tyrosine is a natural amino acid which helps the body produce its own thyroid hormone. This is also known to help with the depression, which usually accompanies hypothyroidism. Most naturopaths recommend that 500 mg. be taken 2-3 times daily. L-Arginine - Arginine is known to stimulate the thyroid and its hormones. It also improves immune function, improves fertility, and alleviates erectile dysfunction. Iodine - The thyroid needs iodine to function properly, and lots of people now suffer from iodine deficiencies. To test yourself, place some iodine (we use 2%) on your stomach. Make a dot the size of a silver dollar (or twice the size of a British 50p). If it disappears within 12 hours, then you are iodine deficient. Keep adding iodine in increasing amounts, until it no longer disappears in a 12-hour period. This works due to the fact that the body absorbs iodine at the rate at which it is needed. Do not use povidone iodine and do not orally consume iodine. This is especially an important precaution for those with Hashimoto's thyroiditis. Avoid all sources of fluoride - As already mentioned, fluoride suppresses the thyroid, and is likely to be the leading cause of hypothyroidism. Drink spring water, avoid soft drinks, use fluoride-free toothpaste, use a shower filter, and throw away non-stick cookware. Both coffee and tea naturally contain fluoride, so use iodine to compensate if these drinks are indispensable. Eat a natural diet - To help the body to heal itself, remove burdens on its immune system. This means that all processed foods, artificial flavors, colors, preservatives, white flour, white sugar, table salt, hydrogenated oils, aluminum, high fructose corn syrup, and etcetera should be eliminated from the diet. Organic food is the ideal. Do not trust marketing that reads "All Natural", because this phrase is unregulated, so anyone can use it for anything. Read labels carefully. Chlorophyll - Supplementing with chlorophyll provides essential copper, helps oxygenate the body, builds healthy red blood cells, and it overall assists with skin health. Chlorophyll is a safe method of orally supplementing with copper. Those who are using our Colloidal Copper Lotion are unlikely to need more copper. Zinc and Selenium: Studies indicate that severe zinc or selenium deficiencies can cause decreased thyroid hormone levels. Never take zinc on an empty stomach. Brazil nuts are high in both zinc and selenium. Coconut Oil: Buy organic, cold-pressed, coconut oil from a health food store. Take around 1 teaspoon of it daily. You can also use it to cook with, but be warned that it smokes at low cooking temperatures, so it should only be used for low-heat cooking. Coconut oil speeds the metabolism, encourages production of the thyroid hormone, and kills candida yeast.
Просмотров: 517 Jim Glemer
This is my review of L-Theanine after taking it for 7 Days: After doing a lot of research myself on all different types of Nootropics (Cognitive Enhancers) I decided to try the most basic Nootropic that comes to mind and certainly the most efficacious and inexpensive: L-Theanine. It is a naturally occurring amino acid found in Green Tea and contributes to feelings of calmness by increasing GABA release in the brain. It's totally safe to use everyday even in high doses reported by many case studies. The many benefits reported of L-Theanine is that it helps with: stress, anxiety, mood, focus, depression and some ADHD symptoms. Dosage Information: 200-400mg L-Theanine daily, taken 1 or 2 times a day.
Просмотров: 95722 That Vu Nguyen
You Gotta Check This Website Out! http://healingideas.org/ Link to the Study – https://pubchem.ncbi.nlm.nih.gov/compound/65340 Recommended Books - Dopamine Handbook 1e Edition http://amzn.to/2zC99Zc The discovery of dopamine in 1957-1958 was one of the seminal events in the development of modern neuroscience, and has been extremely important for the development of modern therapies of neurological and psychiatric disorders. Dopamine has a fundamental role in almost all aspects of behavior: from motor control to mood regulation, cognition and addiction and reward, and dopamine research has been unique within the neurosciences in the way it has bridged basic science and clinical practice. Over the decades research into the role of dopamine in health and disease has been in the forefront of modern neuroscience. The Dopamine Handbook is the first single-volume publication to capture current progress and excitement in this dynamic research field. Dopamine, Catecholamine, Neurotransmitter, Movement, Heart Rate, Output, Blood Vessel Constriction, Blood Vessel Dilation, Salt Excretion, Urine Flow, Blood Pressure One of the catecholamine NEUROTRANSMITTERS in the brain. Dopamine is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is important in regulating movement Dopamine increases heart rate and force, thereby increasing cardiac output. Dopamine causes vasoconstriction and results in an increase in systemic vascular resistance in vascular smooth muscle. Dopamine leads to renal blood vessel dilation, increases glomerular filtration rate, renal blood flow, sodium excretion, and urine flow. Dopamine maintains blood pressure
Просмотров: 423 Healthful Studies
Subscribe to this channel: https://www.youtube.com/channel/UCKDwY2bhQtcMUZ3UFdN3Mng?sub_confirmation=1 Other Endocrinology Lectures: https://www.youtube.com/playlist?list=PLfBFwAwues0l7OpPoCazPLoOPTkRfUsRR Pheochromocytoma (PCC) is a neuroendocrine tumor of the medulla of the adrenal glands (originating in the chromaffin cells), or extra-adrenal chromaffin tissue that failed to involute after birth, that secretes high amounts of catecholamines, mostly norepinephrine, plus epinephrine to a lesser extent. Extra-adrenal paragangliomas (often described as extra-adrenal pheochromocytomas) are closely related, though less common, tumors that originate in the ganglia of the sympathetic nervous system and are named based upon the primary anatomical site of origin. The signs and symptoms of a pheochromocytoma are those of sympathetic nervous system hyperactivity, including: Skin sensations Flank pain Elevated heart rate Elevated blood pressure, including paroxysmal (sporadic, episodic) high blood pressure, which sometimes can be more difficult to detect; another clue to the presence of pheochromocytoma is orthostatic hypotension (a fall in systolic blood pressure greater than 20 mmHg or a fall in diastolic blood pressure greater than 10 mmHg upon standing) Palpitations Anxiety often resembling that of a panic attack Diaphoresis (excessive sweating) Headaches – most common symptom Pallor Weight loss Localized amyloid deposits found microscopically Elevated blood glucose level (due primarily to catecholamine stimulation of lipolysis (breakdown of stored fat) leading to high levels of free fatty acids and the subsequent inhibition of glucose uptake by muscle cells. Further, stimulation of beta-adrenergic receptors leads to glycogenolysis and gluconeogenesis and thus elevation of blood glucose levels). A pheochromocytoma can also cause resistant arterial hypertension. A pheochromocytoma can be fatal if it causes a hypertensive emergency, that is, severely high blood pressure that impairs one or more organ systems (formerly called "malignant hypertension"). This hypertension is not well controlled with standard blood pressure medications. Not all patients experience all of the signs and symptoms listed. The most common presentation is headache, excessive sweating, and increased heart rate, with the attack subsiding in less than one hour. Tumors may grow large, but most are smaller than 10 centimetres (4 in). The diagnosis can be established by measuring catecholamines and metanephrines in plasma (blood) or through a 24-hour urine collection. Care should be taken to rule out other causes of adrenergic (adrenaline-like) excess like hypoglycemia, stress, exercise, and drugs affecting the catecholamines like stimulants, methyldopa, dopamine agonists, or ganglion blocking antihypertensives. Various foodstuffs (e.g. coffee, tea, bananas, chocolate, cocoa, citrus fruits, and vanilla) can also affect the levels of urinary metanephrine and VMA (vanillylmandelic acid). Imaging by computed tomography or a T2 weighted MRI of the head, neck, and chest, and abdomen can help localize the tumor. Tumors can also be located using an MIBG scan, which is scintigraphy using iodine-123-marked metaiodobenzylguanidine. Even finer localization can be obtained in certain PET scan centers using PET-CT or PET-MRI with [18F] fluorodopamine or FDOPA. Pheochromocytomas occur most often during young-adult to mid-adult life. These tumors can form a pattern with other endocrine gland cancers which is labeled multiple endocrine neoplasia (MEN). Pheochromocytoma may occur in patients with MEN 2 and MEN 3 (MEN 2B). Von Hippel Lindau patients may also develop these tumors. Patients experiencing symptoms associated with pheochromocytoma should be aware that it is rare. However, it often goes undiagnosed until autopsy; therefore patients might wisely choose to take steps to provide a physician with important clues, such as recording whether blood pressure changes significantly during episodes of apparent anxiety. Surgical resection of the tumor is the treatment of first choice, either by open laparotomy or laparoscopy. Given the complexity of perioperative management, and the potential for catastrophic intra and postoperative complications, such surgery should be performed only at centers experienced in the management of this disorder. In addition to the surgical expertise that such centers can provide, they will also have the necessary endocrine and anesthesia resources. It may also be necessary to carry out adrenalectomy, a complete surgical removal of the affected adrenal gland(s). more: https://en.wikipedia.org/wiki/Pheochromocytoma
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You Gotta Check This Website Out! http://healingideas.org/ Link to the Study – https://pubchem.ncbi.nlm.nih.gov/compound/5816 Recommended Books - Epinephrine in the Central Nervous System http://amzn.to/2AI0rGN Long thought to be unimportant in central nervous system activity, epinephrine is now known to play a key role in the brain's regulation of blood pressure, cardiovascular function, and other autonomic activities. This encyclopedic volume, written by leading international researchers, offers a comprehensive account of the chemical neuroanatomy, genetics, chemistry, and pharmacology of CNS epinephrine and its effects on behavior and autonomic function. Research Progress on Epinephrine Hardcover – May 2, 2013 http://amzn.to/2yC08fe This book is devoted to new research on epinephrine (INN) sometimes spelled 'epinephrin' or 'adrenalin' respectively, which is a hormone when carried in the blood and a neurotransmitter when it is released across a neuronal synapse. It is a catecholamine, a sympathomimetic monoamine derived from the amino acids phenylalanine and tyrosine. When secreted into the bloodstream; it rapidly prepares the body for action in emergency situations. The hormone boosts the supply of oxygen and glucose to the brain and muscles, while suppressing other non-emergency bodily processes (digestion in particular). It increases heart rate and stroke volume, dilates the pupils, and constricts arterioles in the skin and gut while dilating arterioles in skeletal muscles. It elevates the blood sugar level by increasing catalysis of glycogen to glucose in the liver, and at the same time begins the breakdown of lipids in fat cells. Like some other stress hormones, epinephrine has a suppressive effect on the immune system. Although epinephrine does not have any psychoactive effects, stress or arousal also releases norepinephrine in the brain. Adrenaline and the Inner World: An Introduction to Scientific Integrative Medicine Paperback – February 8, 2006 http://amzn.to/2hpnJsG This accessible work is the first in more than seventy-five years to discuss the many roles of adrenaline in regulating the "inner world" of the body. David S. Goldstein, an international authority and award-winning teacher, introduces new concepts concerning the nature of stress and distress across the body's regulatory systems. Discussing how the body's stress systems are coordinated, and how stress, by means of adrenaline, may affect the development, manifestations, and outcomes of chronic diseases, Goldstein challenges researchers and clinicians to use scientific integrative medicine to develop new ways to treat, prevent, and palliate disease. Adrenaline and the Inner World is designed to supplement academic coursework in psychology, psychiatry, endocrinology, cardiology, complementary and alternative medicine, physiology, and biochemistry. It includes an extensive glossary. Epinephrine, Adrenaline, Heart, Lung, Gastrointestinal Relaxation, Blood Vessels, Brain, Asthma, Anesthesia, Eye, Blood Pressure, Cardiac Arrest Epinephrine is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS. Epinephrine causes systemic VASOCONSTRICTION (narrowing of blood vessels) and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. This agent binds to receptors in the iris sphincter muscle, resulting in vasoconstriction and lowering of intraocular eye pressure. Epinephrine increases the force and rate of heart contractions and relaxes lung bronchial smooth muscle, resulting in bronchodilation. (Enlargement of tubes that channel inhaled air down into the lungs) Epinephrine intravenous injection is used in the treatment of acute asthmatic attacks to relieve bronchospasm, and treatment and prophylaxis of cardiac arrest When given by rapid intravenous injection, it produces a rapid rise in blood pressure, mainly systolic, by (1) direct stimulation of cardiac muscle which increases the strength of ventricular contraction, (2) increasing the heart rate and (3) constriction of the small blood vessels in the skin, mucosa and splanchnic areas of the circulation. When given by slow intravenous injection, epinephrine usually produces only a moderate rise in systolic and a fall in diastolic pressure. Although some increase in pulse pressure occurs, there is usually no great elevation in mean blood pressure.
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Visit http://www.herbworks.com - Roger Drummer, the formulator of TianChi and Inner Peace, discusses Nutraceuticals in TianChi and Inner Peace. TianChi is a real energy drink focused on how you conserve and make energy. Stress causes energy loss due to putting the body in constant survival mode. The adaptogenic herbs in TianChi relax the nervous system and focus the brain in the frontal lobe. This promotes brain coherence - a state of balanced energy patterns indicating the entire brain is communicating. One of the aspects of TianChi that makes it so unique is the utilization of nutrients to fuel the brain. Under constant stress, the requirement for nutrients needed for proper brain function is accelerated. This puts an enormous strain on the brain as it is already starving for nutrients. In my own personal experience of helping people with memory issues, I find that most people have a brain suffering from the starvation of certain nutrients. This has been going on for decades and creates suboptimal brain function and premature aging of the brain. Some of the common complaints of chronically stressed people are feeling overwhelmed and slow—not being able to keep up with the flood of information and activity of modern living. TianChi’s blend of nutrients helps the brain power up and speed up, to keep up and enjoy life. D-Ribose is food for ATP, the energy molecule that supplies most cellular energy. ATP is produced in the mitochondria of the cell. Athletes and chronically stressed people have one thing in common - an accelerated need for ATP. If it’s not replenished on a daily basis performance suffers. D-Ribose ensures you keep up with the demands for ATP. Tyrosine is an amino acid the brain needs to make dopamine, the neurotransmitter that power up the brain and controls sugar cravings. Under normal circumstances you can make tyrosine out of another protein amino, phenylalanine. Stress interferes with your ability to make the conversion and so a direct supply of tyrosine becomes essential to your brain. The best time for protein is the first meal of the day to power up the brain with dopamine and set it for the day. This is why we suggest TianChi first thing in the morning. The added tyrosine boosts dopamine and brings the energy up to the frontal lobe. DMG or dimethylglycine, is a glycine derivative that enhances oxygen utilization and reduces lactic acid. I use it because it also supports the energy of the pituitary gland. This contributes to the concentration of energy in the frontal lobe and promotes brain coherence. Choline is an essential nutrient needed to make the neurotransmitter acetylcholine, responsible for brain speed and memory. Acetylcholine is often lacking in all diseases involving memory loss and 90% of Americans are deficient in this nutrient. In certain situations such as autoimmune disease, the brain may break down the nerves own myelin sheath searching for choline. This contributes to the theory of starvation of the brain. DMAE or dimethylethanolamine is an acetylcholine precursor and one of the original treatments for ADD. As people age, choline becomes more difficult to absorb and convert to acetylcholine so it’s best to have an alternative. DMAE helps the brain speed up and handle information. Taurine and glycine are both inhibitory amino acids, meaning they calm the nervous system. Taurine helps detox the liver and is beneficial to the heart. Glycine combines with many toxic substances and assists in their removal from the body. It has a positive effect on memory and attention, and promotes good sleep. The use of Taurine and glycine contribute to the effect of TianChi creating what we call “Calm, Clear, Energy.”
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Many people ask about l-theanine for anxiety and ADHD. We explain why there is so much discussion over l-theanine and whether it is worth trying. A fair number of subscribers have asked us about using l-theanine for anxiety. Consequently, in this video, we will explain why there is so much discussion over l-theanine and whether it is worth trying. Theanine is found in green tea. Consequently, it is important to have more information about green tea. L-theanine significantly increases alpha frequency band waves in the brain. Alpha brain waves are associated with the default "relaxed and alert" mode of the brain. A study featured by PubMed.gov indicated that l-theanine has a direct effect on the brain The aim of this research was to establish whether this effect occurred at more realistic dietary levels. At Panic Attack Recovery we are former sufferers teaching others how to be proactive and take charge of their anxiety and panic attacks. We provide a comprehensive solution to anxiety so that you get better and stay that way! We'd love to have you subscribe and join us. WE POST NEW VIDEOS EVERY WEDNESDAY! SUBSCRIBE to our YouTube Channel! https://www.youtube.com/panicattackre... GET INSTANT ACCESS to the “5 Steps to Recovery from Anxiety, Stress, Panic Attacks, and Agoraphobia” in our free, continuous email newsletter: https://panicattackrecovery.com/newsl... LET'S CONNECT! -- http://www.facebook.com/panicattackre... -- http://twitter.com/panicrecovery LISTEN TO THE PANIC ATTACK RECOVERY PODCAST: - iTunes: https://panicattackrecovery.com/PARiT... - Website: https://panicattackrecovery.com/podcast
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This amazing amino acid has provided a great many people with relief from stress and anxiety. This video explains some of the benefits that myself and others have discovered by supplementing with L-theanine. If you're thinking about trying it out it can be bought through many sources online as it is gaining popularity over the last years and naturally you have the freedom to choose whether you want to get it in capsules or powder form. If you want to gather more knowledge about this supplement I can recommend you to read it here: http://examine.com/supplements/Theanine/ Subscribe if you found this useful or want me to create more videos like this :). Thanks for any feedback given!
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Somehow just stumbled across the most beneficial supplement in my life five days ago. L -THEANINE-The effects this amino acid has on the body are incredible. It's found in green tea, the most consumed beverage IN THE WORLD only behind water. It acts as a natural xanax lifting mood by increasing dopamine helping depression, helps with mediation by putting the brain in an alpha wave state, you'll be able to get in the "zone" much more easily, things will seem effortless as you flow through the day..lowers blood pressure, when combined with caffeine acts like a natural Adderall..combats the negative effects of alcohol by eliminating free radicals in the body..natural hangover cure in 30 mins..stress reliever, reduces anxiety..helps you sleep better! Disclaimer: Not a medical doctor- have to say that for Youtube-
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Hannah reviews Cardio Juvenate Plus, the all natural heart healthy arginine supplement that lowers blood pressure and increases energy.
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Hypertension (B.P) Treatment in Nadipathy Hypertension (B.P) is the pressure of the blood against the walls of the arteries. Your heart pumps blood through a network of arteries, veins, and capillaries. The moving blood pushes against the arterial walls, and this force is measured as blood pressure. Blood pressure results from two forces. The heart creates one force as it pumps blood into the arteries and through the circulatory system. The other is the force of the arteries as they resist the blood flow. The higher, systolic number represents the pressure while the heart contracts to pump blood to the body. The lower, diastolic number represents the pressure when the heart relaxes between beats. The systolic pressure is always stated first and the diastolic pressure second. The blood pressure below 120 over 80 mmHg (millimeters of mercury) is considered ideal for adults. A systolic pressure of 120 to 139 mmHg or a diastolic pressure of 80 to 89 mmHg is considered "pre–hypertension" and needs to be watched carefully. A blood pressure reading of 140 over 90 or higher is considered elevated or high. High blood pressure usually has no symptoms. In fact, many people have high blood pressure for years without knowing it. That's why it's called the "silent killer." Affects of Hypertension: Enlarged heart Eye damage Liver damage Kidney damage Paralysis Hardening of arteries Tremors (Shivering fingers) Causes of Hypertension: Eat a diet high in salt Being over weight Eat a diet high in sea foods Smoking habits THYROID TREATMENT IN NADIPATHY The Thyroid is a butterfly shaped gland that found in the neck region. It is one of the largest endocrine gland to maintain metabolic activities in our body. The Thyroid gland controls how quickly the body uses energy, makes proteins and controls how sensitive the body should be to the other hormones. It participates in these processes by producing thyroid hormones, the principle ones being triiodothyronine (T3) and thyroxin (T4). These hormones regulate the rate of metabolism and affect the growth and rate of function of many other systems in the body. T3 and T4 are synthesized from both iodine and tyrosine. The thyroid also produces calcitonin, which plays a role in calcium homeostasis. Hormonal output from the thyroid is regulated by thyroid –stimulating hormone (T.S.H) produced by the anterior pituitary, which itself is regulated by thyrotropin – releasing hormone (T.R.H) produced by the hypothalamus The most common problems of the thyroid consist of an over-active thyroid gland, referred to as hyperthyroidism and under-active thyroid gland is referred as hypothyroidism. Symptoms of hypothyroidism: Fatigue, Forgetfulness, Dry skin, Dry hair, Brittle nails, Constipation, Muscle cramps, Depression, Decreased menstrual flow, swelling in-front of neck (goitre). Symptoms of hyperthyroidism: Feeling hot, Sweating, Sleep-lessness, Racing thoughts, Difficulty to focusing on one thing, Forget fullness, Change in bowel habits, Elevated heart rate, Anxiety, Nervousness (or) irritability, Weight loss, Menstrual problems. For more information: Blog: http://thyroidtreatmentinnadipathy.blogspot.in/ Youtube: http://www.youtube.com/playlist?list=PLmYxb4HnTMmHBULz5ZUDjDPvMtvY-Xh8H Nadipathy Centers: Global Center: Nadipathy Ramanyya peta, Kakinada,E.G.Dt,AP 0884-6459111, 8885011326/329 Branch: Nadipathy Vydehi Nagar,Vanasthalipuram,opp:Sri indhu PG College,Hyderabad 040-65459111, 8885011322/323/324 For more details visit: www.nadipathy.in Youtube:https://www.youtube.com/channel/UCsp8QjBeKIr7KAM1LT23Fxw/playlists https://www.youtube.com/channel/UCyjOy4Xo6e31qistP_OPS0Q/playlists
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Grade 12 ISU that explains the maternal condition, preeclampsia, in depth. Below there is a question and answer sheet you can try. Preeclampsia Video Question & Answer Sheet 1) What percent of the fetuses and women in Canada affected by this condition? Answer: 25% of mothers and 50% of fetuses are affected. 2) What are the three main signs of preeclampsia that a mother may experience? Answer: High blood pressure (hypertension), protein leaked in the urine (proteinuria) , and swelling (edema). 3) What is the only cure to preeclampsia? Answer: To give birth. 4) What is the difference between a healthy placenta versus the placenta of a preeclampsia patient? Answer: A preeclampsia placenta has constricted arteries resulting in high blood pressure and less blood flow to the fetus. 5) What colour does the dipstick change to when it shows a positive result of protein during urinalysis? Answer: Green. 6) What is sFlt-1 and what are the two things it antagonizes? Answer: It stands for soluble fms-like tyrosine kinase-1. It acts as an antagonist of circulating vascular endothelial growth factor (VEGF) and placental growth factor (PlGF).
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[New Video] ★ 7 Easy - Healthy Smoothie Recipes for Weight Loss → https://www.youtube.com/watch?v=xwS2T5-JnJg In this video, we are helping you chose Best l-Theanine Supplement based on their quality, price and many more factors. We tested a lot of them, and in the end we came up with this top 5 list for you guys. The Best l-Theanine Supplement Listed In This Video: 5. NOW L-Theanine ★ http://amzn.to/2zSkC6U 4. Source Naturals L-Theanine Tablets ★ http://amzn.to/2hJSdt5 3. Superior Labs L-Theanine ★ http://amzn.to/2iu8wXZ 2. Nature's Trove L-Theanine ★ http://amzn.to/2zSkfcw 1. Nutricost L-Theanine ★ http://amzn.to/2yX6WEy Thank you for watching, if this video helped you please leave a like and subscribe. If you have any questions please post them in the comments section below!
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http://www.trubrain.us TruBrain is the world's first nootropic drink. Dr. Hill and Dr. Drew discuss the effects of L-Theanine, Coffee and Caffeine on the brain and how to use each effectively. truBrain was designed by top neuroscientists who have been studying cognitive optimization for decades–led by Dr. Andrew Hill and Dr. Aida Attar of UCLA. truBrain’s goal is to give you the competitive edge of focused cognitive performance as an everyday alternative to caffeine and energy drinks. We crafted our products using active nootropics that support focus, validated with wearable technology. - Crafted with the perfect amounts of active nootropics - Loaded with amino acids to fuel the thinking process - Flavored with all natural ingredients like blue agave and monk fruit - Provides direct support for concentration and focus Active Nootropics: - Oxiracetam + Citicoline - Caffeine + L-Theanine - Magnesium + Tyrosine - Carnitine http://trubrain.us/ https://www.facebook.com/BestNootropicsBrainPill/ https://www.youtube.com/watch?v=DX4ICRL-REk https://www.youtube.com/watch?v=j1HfX5eDczk https://www.youtube.com/watch?v=DrKhTszkp2A https://www.youtube.com/channel/UCctAHE1tidQ-nZ_WWvNPQjQ #vitaminsformemory #bestbrainsupplements #vitaminformemory #memorysupplements #memorypills #brainpill #memoryvitamins #Nootropics #brainvitamins #trubrain #brainpills #smartdrugs #memoryimprovement #smartdrug #improvingmemory #smartpill #smartpills #limitlessdrug #bestnootropics #brainpower #bestnootropic #brainhealth #cognitiveenhancers #brainfog #limitlesspill #drdrew
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http://www.beautynhealth.com : Steven Bass: President of F.T.H. Nutraceuticals interviews Don Tyson the world's foremost authority in amino acids.
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-http://www.ageproofyourinnerbody.com (385)220-2610 Nitric Oxide is an aid in ED (impotence)/ Libido. New study stating the results of enhanced Nitric Oxide manufacturing on the body, favorably impacting ED (impotence). The Nitric Oxide fight against Heart Disease and Cholesterol. Heart disease asserts a lot more lives then Cancer, Accidents, Respiratory condition, and Diabetes COMBINED. Nitric Oxide advantages to High Blood Pressure (AKA Hypertension). High blood pressure is called the "Silent Killer" given that for the most part it will never produce noticeable symptoms, yet it causes prevalent damages to the Brain, Heart, Kidneys, and numerous other crucial body organs. With L-Arginine Complete, you are giving your body an abundance of Nitric Oxide, which puts the body in continuous "ATHLETIC MODE.".You can find terrific info about L-Arginine Complete here: http://ageproofyourinnerbody.com 385-220-2610 https://www.youtube.com/watch?v=K6JtpUblPUs
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Thermo Burn What Does it Claim to do? Slimming Solution Ltd presents Thermo Burn as an advanced thermogenic diet complex formulated to help men’s body easily convert food into energy source, increase* metabolic rate and raise temperature in order to burn more fat. Thermo Burn Ingredients – Are they Safe & Effective? There are 5 active ingredients found in Thermo Burn. Here they are Chromium Polynicotinate: This ingredient is quite popular in many weight loss* supplements. Its main use is to regulate blood sugar levels and prevent sugar craving which may lead to overeating. L-Tyrosine: Some studies suggest that when combined with other ingredients, it can help suppress* appetite, improve* metabolism and thyroid functions. L-Phenylalanine: This is an amino acid that gets converted into Tyrosine when inside the body. No wonder it has a similar role, that is, it helps suppress* appetite. Korean Ginseng: This plant extract is known to provide the body with nutrients that fortify it and boost* its energy. The ingredient is also used to cope with stress. Calcium Pyruvate: It is involved in the conversion of sugar into energy. This results in an improved* metabolism and increase* in body temperature. How Does it Work? Three of the ingredients used in the product are to improve* the assimilation of sugar and increase* body temperature. The other 2 ingredients play a role in suppressing appetite. So basically the strategy used in this supplement to cause weight loss* is to burn more calories and reduce* the amount of food intake. What are the Advantages of Thermo Burn? Thermo Burn is relatively cheaper compared to other similar healthy weight loss* pills. The supplement does not contain any stimulant like caffeine It improves* the assimilation of sugar and increases* body temperature It gives the user more control over his appetite It is formulated by a company that has over 10 years’ experience in the supplement field What are the Disadvantages of Thermo Burn? There is no conclusive evidence that the supplement really works The manufacturer fails to provide a full ingredient profile The product is not vegetarian nor vegan friendly There is nothing in this product that shows it was specifically formulated for men Dosing Information Each bottle of Thermo Burn contains 60 capsules to be finished in the course of 20 days. Users are expected to take 3 capsules daily. You should take 1, fifteen minutes before each meal. Is Thermo Burn safe? The good news is Thermo Burn does not contain any stimulant to be worried about. That said you need to keep in mind that Korean ginseng is an ingredient to be avoided by individuals suffering from high blood pressure. Thermo Burn Review – Final Verdict Slimming Solutions wants us to believe that it was able to come up with a formula that could help men reshape their body and bring back their 6 packs. Unbiased diet pill reviews show that there is nothing so special about this supplement. There is nothing about it showing why it is supposed to be used by men only. Maybe the ingredients in it have a slight effect but there is no conclusive evidence that you can lose* a significant amount of weight when on this pill. You can Read more about Thermo Burn in our Full Review Article over on our website at: http://1800healthfitness.com/thermoburn-review.html Join our Book Of the Month Club for FREE healthy tips on how you can improve your lifestyle.: http://1800healthfitness.com/free-book.html Check out our other Product Reviews: https://www.youtube.com/playlist?list=PLSXXFGoFKN_5m_v0EP7SSqmYrDXUQnAvD
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The late Scottish pharmacologist Sir James W Black (1924-2010) revolutionised medical treatment of hypertension and angina with his invention of propranolol, the first ever beta blocker. He was awarded the Nobel Prize in Physiology or Medicine in 1998. [Listener: William Duncan] TRANSCRIPT: In the early days of beta blockers clinicians found that if you had a patient in heart failure and you gave them a beta blocker well, undoubtedly, some, one or two patients died, but it was bad news, as though you needed your beta receptors in the heart to protect you against heart failure. And so physicians taught for years: never give a beta blocker to patients with heart failure. Then a physician in Gothenburg in Sweden – I don't know why Sweden keeps coming up but there it is, it's a very exciting place scientifically – had patients with what's called dilated cardiomyopathies in which one of the problems is high heart rates, and he felt, 'If only I could reduce the heart rate, I feel they'd be more comfortable', and the only way he knew to do that was with a beta blocker. So, he started experimenting giving a little dose and for the first 24 hours it didn't look good, but then he had the courage to keep going, and after a couple of days they began to get a little bit better, and so he kept going and then he would increase the dose, get worse, then get better, and grad... and he titrated them, and he was bringing patients out of heart failure with a beta blocker. So that was '75 that was published. By 2000, 15 years later, we had now got four huge studies done. By huge I mean about 5000 patients in each, with four different marketed beta blockers. One was metoprolol – AstraZeneca/ICI compound – which is classified oh, I have to, I'm missing out a big piece. When I was at ICI we had alpha receptors and we had beta receptors. In the meantime we found there was many types of alpha receptors and many types of beta receptors. In fact, three are recognised, and they're called beta-1, beta-2, and beta-3. And, back in the early days, after I had left ICI, they went on to make selective beta 1 receptor antagonist, still marketed as atenolol. And so, there was a number of selective beta-1 antagonists but just, of which metoprolol – which they acquired by taking over a Swedish company – was one. So, AstraZeneca metoprolol. Then there was another compound called bisoprolol which was classified as a beta-1 antagonist. Then another company in the States had been marketing carvedilol as a non-selective and it blocked both beta-1 and beta-2, but it did some other things, but beta-1 and beta-2; carvedilol. And then the fourth one was bucindolol classified as non-selective. So two selective for beta-1 and two non-selective. In each case a pattern was found of titration. You start with small dose and gradually build them up; first 24 hours they get worse and then they get better, and you can so now Finn Waagstein who was the man who started all this in 1975, Gothenburg, he says, 'What we have in common in these four drugs are beta 1 receptor block, so it's the beta 1 receptor blockade which is doing the business'. Now, pharmacologists, clinical pharmacologists I'm afraid, and clinicians, talk about beta-1 selectivity as though it was a quality, when in fact it's a quantity. And in the case of metoprolol the quantity is surprising small. Now, when we are comparing potencies, you take a dose response curve and one system, and a dose response in the other, and you compare the 50% points; you compare it horizontally. But therapeutically what you do is you titrate up towards the top of those response curves, and when you get up there the difference between the two tops narrows, so down at the 50% point metoprolol is four full selective. Up at the top it's not selective at all. And so I showed them data that all of these drugs are producing significant beta-2 receptor blockade. Now, why am I excited by that? Because when I started I was interested in heart rate, and it so happened, as we now know, that the pacemaker of the heart has only got beta-1 receptors, whereas the ventricles have got beta-1 and beta-2. Now, whenever a beta receptor agonist acts on the beta receptor it switches on the production of what are called G-proteins, and specifically beta-1 generates what's called GS-proteins–S for stimulation–and the GS-proteins switch on phosphorylating enzymes, and one of these phosphorylating enzymes phosphorylates the receptor and inactivates it. So you stimulate it; chain goes; inactivation; then it's recycled. The beta-2 is the same. It couples to GS. But once it has been phosphorylated and inactivated for GS coupling, it now couples to another G-protein called GI. So, here we now have the production of GI-proteins once the receptor is phosphorylated. Now, GI-proteins–I is for inhibition–does just that, inhibits the contractions but we also know it does an awful lot of other things downstream to what are called tyrosine kinase enzymes.
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