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Johns Hopkins Kimmel Cancer Center Virtual Tour
Experience the Center by taking a virtual tour of our clinical care building. "Walk" through our facilities to learn more about services and programs. Prepare for your first visit with this step-by-step guide.
Просмотров: 26952 Johns Hopkins Medicine
The Johns Hopkins Kimmel Cancer Center on the Johns Hopkins Bayview Campus Tour
Take a video tour of the Johns Hopkins Bayview Medical Center campus’ Sidney Kimmel Comprehensive Cancer Center and its state-of-the-art facilities for cancer treatment, part of the only facility in the state of Maryland to earn a Comprehensive Cancer Center designation from the National Cancer Institute. Meet some of the multidisciplinary team of physicians and staff members who provide comfort and individualized, world-class cancer care to our patients. To learn more http://www.hopkinsmedicine.org/johns_hopkins_bayview/medical_services/specialty_care/cancer_services/index.html
Просмотров: 2715 Johns Hopkins Medicine
The Johns Hopkins Kimmel Cancer Center’s groundbreaking event
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins held a groundbreaking event on Sept. 10, 2015 on a new $100 million, 184,000-square-foot cancer care building at one of the highest elevations in East Baltimore. Slated to open in late 2017, the building is named for Albert P. “Skip” Viragh Jr., a Maryland mutual fund investment leader, philanthropist and pancreatic cancer patient treated at Johns Hopkins who died of the disease in 2003 at age 62. The Skip Viragh Outpatient Cancer Building will provide clinical services to patients with solid tumors, accounting for more than 180 current patients daily and 60 to 80 new patients each week. http://www.hopkinscancer.org
Просмотров: 1654 Johns Hopkins Medicine
2016 Summer Symposium: Bert Vogelstein
Bert Vogelstein, Johns Hopkins University Cancer genomes and their implications for prevention https://ki.mit.edu/news/symposium/2016
Просмотров: 2458 KochInstituteMIT
Meet neurosurgeon Jeffrey Weinberg
http://bit.ly/2DCUhNs Dr. Jeffrey Weinberg is currently a Professor and Director of Training in the Department of Neurosurgery at The University of Texas MD Anderson Cancer Center in Houston, Texas. He is also the Director of the Intraoperative MRI Program. Dr. Weinberg is a leader in the field of Neurosurgery with particular knowledge about intraoperative MRI and technical expertise in surgical management of primary and metastatic brain tumors, spinal cord tumors, stereotactic radiosurgery, intraoperative delivery of anti-cancer agents, as well as pediatric brain tumors. He has received various honors which include Excellence in Research Mentorship from the University of Texas Center for Biomedical Engineering, Houston, TX; the Excellence in Teaching Award from the University of Texas Center for Biomedical Engineering for three consecutive years, and Top Doctor’s Designation by Castle Connolly and US News and World Report. Dr. Weinberg is a member of the Faculty Senate Education Committee; Chair of the Perio-operative Value Analysis Team; the Chair of the Scientific Program Committee for the 2012 Intraoperative Imaging Society Annual Meeting; incoming Vice President of the Texas of Neurological Surgeons; Chair of the search committee for the Chief of Neuropyschology. He has published more than 50 manuscripts in peer-reviewed journals and has authored 8 book chapters. He is invited to numerous conferences and symposiums throughout the year.
Просмотров: 286 MD Anderson Cancer Center
Beyond the Visible: Adult Stem Cells and Cancer
Docent Petri Salvén has spent two decades researching the mechanisms of angiogenesis - the growth of new blood vessels - to identify ways to accelerate or block it. He is particularly intrigued by the source of highly specialised endothelial cells in blood-vessel walls and by the possibility to enhance or prevent the generation of such cells. Researchers track down stem cells in blood vessel walls: http://www.helsinki.fi/news/archive/10-2012/17-16-30-43 Music: Travis Morgan, Time Decay (ccmixter.org) Filmed by Claudia Gorr
Просмотров: 3155 University of Helsinki
Dr. Weinberg, Plastic Surgery – Neurofibromatosis Testimonials
Dr. Hubert Weinberg is one of the world’s premier plastic surgeons when it comes to treating neurofibromatosis (NF). This disease is a genetically-inherited disorder that causes unsightly tumors and growths on the nerve endings under the skin. Often the tumors or neurofibromas are benign. However, they are known to cause physical and emotion distress to patients. Follow the trials and tribulations of Dr. Weinberg’s patients as they discuss their experience with neurofibromatosis and how treatment has helped make their lives easier. Dr. Weinberg is not only a specialist in neurofibromatosis, but a pioneer in its treatment – electrodessication. Using this breakthrough procedure, he is able to eradicate hundreds of neurofibroma from the body for long term success. Subscribe to find out more about Dr. Weinberg and what he can do for you. Subscribe: https://www.youtube.com/channel/UC3e2cRZZiNiEYW9vrcbeV8Q Visit Our Website: http://www.hweinbergplasticsurgery.com/index.html
Просмотров: 745 Dr. Hubert Weinberg M.D.
Harry and Jeanette Weinberg Early Childhood Center & Library Dedication
On Wednesday, September 10, Council President Young spoke at the dedication of the Harry & Jeanette Weinberg Early Childhood Center and the Weinberg Library at Elmer A. Henderson: A Johns Hopkins Partnership School in East Baltimore.
Просмотров: 64 Jack Young
Meet neuro-oncologist John de Groot
http://bit.ly/2oXgivY Dr. John de Groot is a Professor, and Chairman ad interim, in the Department of Neuro-Oncology at The University of Texas MD Anderson Cancer Center. He is an expert in the fields of glioma angiogenesis and molecularly targeted therapy. He completed his medical education at The University of Texas Medical Branch at Galveston, and pursued internship and residency at Johns Hopkins School of Medicine. Following a clinical fellowship at MD Anderson, de Groot joined the faculty in 2004. His translational research program has produced critical insights into how gliomas respond to and resist killing by anti-angiogenic agents and illuminated therapeutic approaches employed in clinical trials to overcome this resistance. De Groot has also significantly contributed to the discovery of biomarkers of response and progression in glioblastoma patients treated with anti-angiogenic therapy, and as a result has opened multiple biomarker-driven clinical trials. Dr. de Groot has served as the principal investigator (PI) or co-investigator on multiple funded National Cancer Institute, foundation, and industry-sponsored grants. He is the PI of numerous clinical trials involving novel agents being tested in patients with glioblastoma and is a leader of MD Anderson’s Glioblastoma Moon Shot. As director of the Neuro-Oncology Fellowship Program, he is also helping develop the next generation of neuro-oncologists. Dr. de Groot has eighty peer reviewed articles. He is or has been a peer reviewer for 23 scientific journals, both national & international, and is on four editorial review boards.
Просмотров: 359 MD Anderson Cancer Center
Understanding Cancer Treatment
treating different types of cancers can involve complex strategies and multiple approaches. In this video hear snippets of our doctors at Compassionate Cancer Care discuss misconceptions about treating cancer and the side effects of treatment.
Просмотров: 702 compcancercare
SINAInnovations 2016: Keynote Address – Therapeutics Frontiers in Oncology
Keynote Address – Therapeutics Frontiers in Oncology (Rudin-Kase Dean’s Lecture*) given by Dr. Drew M. Pardoll, Abeloff Professorship of Oncology; Director, Bloomberg-Kimmel Institute for Cancer Immunotherapy; Co-Director, Cancer Immunology, Johns Hopkins School of Medicine. *The Rudin-Kase Dean's Lecture Series at Icahn School of Medicine at Mount Sinai is generously supported by a grant from the Louis and Rachel Rudin Foundation.
Просмотров: 409 Icahn School of Medicine
Going to MIT? Consider a Career in Medical Research
http://www.labtv.com/Home/Profile?researcherId=1542 Meet Arthur "Artie" Lambert, a post-doctoral researcher in the Weinberg Lab of Cancer Biology at MIT. Artie’s research involves researching cancer progression and contributes to trying to find a cure for breast cancer. To learn more about Artie, visit http://www.labtv.com/Home/Profile?researcherId=1542
Просмотров: 61344 LabTV
Stopping Breast Cancer Leader Cells | Science: Out of the Box
Johns Hopkins' cell biologist Andy Ewald explains his latest finding on how breast cancer cells spread and how they might be stopped. http://www.hopkinsmedicine.org/institute_basic_biomedical_sciences/research_centers/cell_dynamics/faculty_research/ewald.html
Просмотров: 12832 Johns Hopkins Medicine
The Lancet Oncology Commission: Future Cancer Research Priorities in the USA — Part 1
The Lancet Oncology Commission: Future Cancer Research Priorities in the USA — Part 2 Top scientists discuss how they recommend expanding and implementing the Blue Ribbon Panel’s road map for cancer research. They’ll discuss a report that will be published by the journal The Lancet Oncology and is co-edited by Elizabeth Jaffee, M.D., deputy director of the Johns Hopkins Kimmel Cancer Center, and Chi Van Dang, M.D., Ph.D., scientific director at Ludwig Cancer Research and professor at The Wistar Institute. Visit Johns Hopkins inHealth at: https://www.hopkinsmedicine.org/inhealth
Просмотров: 362 Johns Hopkins Medicine
Victor Velculescu Delivers 2011 Paul Marks Prize Lecture -- Sloan-Kettering
Victor Velculescu, MD, PhD, is a professor of oncology and co-Director of the Cancer Biology Program at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Dr. Velculescu is internationally known for developing a series of novel genomic technologies and for applying them to making discoveries that improve the basic understanding and clinical care of cancer, including the personalized management of patients. Early in his career, he developed a method called serial analysis of gene expression to simultaneously study thousands of genes and quickly identify differences in gene expression among normal cells and cancer cells. Critical advances stemming from this approach include the first systematic analyses of gene expression for several cancers and the identification of a set of genes -- uniquely expressed in cancer -- that can serve as targets for therapy.
Просмотров: 2172 Memorial Sloan Kettering
Watching Cancer Spread Through Abdominal Window
A small, surgically implanted glass window lets researchers watch the real-time development of cancer in the liver, spleen, kidney and small intestine, reports a new study in animals. The technology shows that metastatic cancer cells are more dynamic than previously thought. Laila Ritsma and colleagues implanted windows into the abdominal walls of mice, gaining a direct view of the animals' internal organs.
Просмотров: 1862 wwwAAASorg
The Harry and Jeanette Weinberg Foundation
Thank you for your interest in The Harry and Jeanette Weinberg Foundation. We hope this video gives you a sense of our mission and areas of focus.
Просмотров: 3240 HJWeinbergFoundation
AACR Special Conference on Colorectal Cancer: From Initiation to Outcomes
This AACR special conference will provide a comprehensive overview of colorectal cancer from tumor initiation through patient outcomes and survivorship. Learn more at www.AACR.org/Colorectal16. Conference co-chairs are Ernest T. Hawk of The University of Texas MD Anderson Cancer Center in Houston, Steven H. Itzkowitz of Mt. Sinai Hospital in New York; Kenneth W. Kinzler of Johns Hopkins Kimmel Comprehensive Cancer Center in Baltimore, and Johanna W. Lampe of Fred Hutchinson Cancer Research Center in Seattle.
Просмотров: 329 American Association for Cancer Research
Cancers Genomes and their Implications for Curing Cancer by Bert Vogelstein
http://biotechnology.jhu.edu/ The full lecture title is "Cancers - Their Genomes, Microenvironments, and Susceptibility to Bacteria-based Therapies" by Bert Vogelstein The Johns Hopkins Center for Biotechnology Education and the Department of Biology in the Krieger School of Arts and Sciences hosted the American Society for Microbiology's Conference for Undergraduate Educators (ASMCUE) on June 2 to 5 on the Homewood campus. Bert Vogelstein gave the closing plenary lecture, "Cancers - Their Genomes, Microenvironments, and Susceptibility to Bacteria-based Therapies" on June 5th. He teaches at John Hopkins University. ASMCUE, now in its 18th year, is a professional development conference for approximately 300 educators. Each year, its steering committee organizes a program that offers access to premier scientists in diverse specialties and to educators leading biology education reform efforts. For more information on the conference, go to http://www.asmcue.org/page02d.shtml
Просмотров: 10483 JHU AAP
The Johns Hopkins Hospital - Baltimore, Maryland
See the current status of The Johns Hopkins Hospital project. SSR was selected for comprehensive voice, data communications and Medical Information Systems (MIS) planning, design and specification for the 1,600,000-square-foot new clinical building, which connects with the Weinberg Building to form a state-of-the-art healthcare facility.
Просмотров: 2095 SSRnashville
#TomorrowsDiscoveries: Chemotherapy-Resistant Breast Cancer Stem Cells - Dr. Gregg Semenza
#TomorrowsDiscoveries: While chemotherapy attacks and kills 99 percent of breast cancer cells, it leaves behind chemotherapy-resistant cancer stem cells, which can later cause metastatic tumors. Dr. Gregg Semenza’s team has identified a way to overcome the resistance of cancer stem cells to chemotherapy, completely eradicating breast tumors in mice. Learn more about Dr. Semenza’s work: http://ow.ly/PrVEo
Просмотров: 2161 Johns Hopkins Medicine
What Is The Biology Of Cancer?
A number of complex scientific the biology cancerchapter metastatic cancer cells in bone marrow (wright giemsa stain micro metastasis breast this analysis and discussion activity introduces students to molecular cellular cancer, including important contributions mutations introduction from johns hopkins university. Html url? Q webcache. Office hours mwf12 12 50 pm the aim of this module is to develop knowledge concepts fundamental ability specialist cancer nurse demonstrate competence across all biology. As part of an ancient egyptian may 28, 2002 this article provides a brief explanation the biology cancer, including its biological and molecular causes. Tumor viruses, cellular oncogenes, growth factors and their the biology of cancer is a textbook for undergraduate graduate students as well medical studying molecular bases metastasis resistant to therapy major cause death from. The oldest descriptions of cancer were written in egypt as early 3000 b. The biology of cancer ( garland science 2007). Gov disease cancer biology url? Q webcache. The text is up to date and provides current information on topics such as tumor stem cells recently introduced chemotherapeutics the biology of cancer by robert weinberg a textbook aimed at graduate medical students. Aacr centennial series the biology of cancer metastasis wiley cancer, 2nd edition janice ann gabriel. Kinetics of cyclin d1 after mitogenic Seer training cell biology cancer. The biology of cancer sphoncolinkunderstanding the introduction to cell shape and why it's important canceredcan. The biology of cancer, 2nd edition by robert garland science. We start by examining the personal, social, and economic consequences of this disease. Similarly, the liver or endocrine organs frequently respond to injury by regenerating damaged cells. Despite almost 200 years of study, the process tumor metastasis remains controversial advances in research and treatment cancer mean that more patients their carers are asking healthcare professionals about latest treatments figure 8. Edu otlt mph cancer ph709_cancer_print. The biology of cancer springerharvard summer school. We then focus on the nature of cancer including an introduction to pathology and clinical aspects. B the biology of cancer ( garland science 2007). Email address bachman@oneonta. Googleusercontent searchcontributors introduction. Googleusercontent searchthe cell is the fundamental unit of life. Mbi 3004 the biology of cancer uit. A new approach download pdf (3533kb)smoking and cancer professor pburch this course explores the biology of. As stated in the previous section, reproduction of cells is a process cell division biology cancer textbook for undergraduate and graduate students as well medical studying molecular cellular bases. The biology of cancer robert allan weinberg google books. Over 500000 people in the united states and over 8 million worldwide are dying feb 1, 2017 why is shape of a cancer cell so important for predicting how disease w
Просмотров: 27 I Question You
Role of Hypoxia in Cancer
Media Project on the effect of PHD1 on Cep192 levels and the regulation of cell cycle progression. This video is based on a Developmental Cell publication by Sonia Rocha, a Principle Investigator in the Centre for Gene Regulation & Expression at the University of Dundee. References Original Research Paper Moser S.C., et al. PHD1 Links Cell-Cycle Progression to Oxygen Sensing through Hydroxylation of the Centrosomal Protein Cep192. Developmental Cell. 2013 Aug 8; 26(4): 381-392. Diagrams Stearns T. The Stearns Lab [Internet]. Stanford University Department of Biology and Genetics [cited 2013 Nov 20]. Available from: http://stearnslab.stanford.edu/WWD.html Ebert S. Mitosis. AP Biology. 2012 Aug 14 [cited 2013 Nov 20]. Available from: http://tinyurl.com/mzfl996 Smith B. Animal Cell Colouring. Smith Life Science [cited 2013 Nov 20]. Available from: http://www.smithlifescience.com/animalcellcolordefine.htm Software Sparkol® Videoscribe Pro. http://www.sparkol.com
Просмотров: 4613 Daniel Bode
Charles Eberhart Discusses Brain Cancer Stem Cells
Johns Hopkins scientist Charles Eberhart discusses recent research on blocking pathways that contribute to brain cancer stem cell growth.
Просмотров: 326 Johns Hopkins Medicine
BCRF 2008 Symposium 14
Defining stem cells, their properties and their role in cancer Response by: Michael F. Clarke, MD (Panelist) Robert A. Weinberg, PhD (Panelist) Introduction by: Larry Norton, MD (Moderator)
Просмотров: 166 Breast Cancer Research Foundation
Building Your CUSP Team | The Armstrong Institute for Patient Safety & Quality
Rhonda Wyskiel, a nurse on the Weinberg ICU at The Johns Hopkins Hospital, provides an overview of the second task along the Pre-CUSP phaseline: identifying and building your CUSP team. It's important to spend time carefully choosing a strong, committed and interdisciplinary group of providers, staff and senior leaders, who together will make a positive impact on the team's efforts to improve unit-level safety.
Просмотров: 491 Johns Hopkins Medicine
Best of iMig 2014 - Dr. Robert Weinberg speaks on Cancer Stem Cell Targeting Therapies
Part of the opening plenary session of iMig 2014 in Cape Town, South Africa - Dr. Robert Weinberg of MIT gives a remote address to his colleagues on the critical role of cancer stem cells in mesothelioma and other malignancies.
2013 Rangos Award for Creativity in Cancer Discovery
The Rangos Award—named for entrepreneur and philanthropist John G. Rangos, Sr.—was created to inspire original ideas and innovative approaches to determine why some cancers are treatable, but others are not. Watch highlights of the 2013 competition.
Просмотров: 488 Johns Hopkins Medicine
Robert Weinberg: 2014 Breakthrough Prize in Life Sciences Symposium
The 2014 Breakthrough Prize in Life Sciences symposium took place on December 13, 2013, at the University of California, San Francisco. The day featured talks on cancer, genetics, neurobiology and stem cells from the 2013 Life Sciences laureates. UCSF Chancellor Susan Desmond-Hellmann also hosted a panel discussion, open to the general public, with the six 2014 Life Sciences laureates. The theme was, "The Future of Biological Sciences."
Просмотров: 4694 Breakthrough
Johns Hopkins Kimmel Cancer Center | Retirement of Moody D. Wharam, Jr. MD
The Johns Hopkins Kimmel Cancer Center honors Moody D. Wharam, Jr. MD on his retirement and for his 40 plus years with The Department of Radiation Oncology and Molecular Radiation Sciences on June 2.
Просмотров: 532 Johns Hopkins Medicine
AACR 2010: Association between weight gain and prostate cancer risk
Corinne E. Joshu, postdoctoral fellow at the Department of Epidemiology at Johns Hopkins Bloomberg School of Public Health, speaks about the association between weight gain and an increased risk of prostate cancer recurrence in the PSA era. Speaking at the 2010 AACR conference.
Просмотров: 77 ecancer
Yoga Three Part Breath Meditation (Dirgha Pranayama) with Steve Wolf E-RYT 500
The oldest form of meditation is almost certainly the act of observing the breath. There are now countless meditation practices and variations, but focused breath awareness endures as an invaluable tool for releasing tension and strengthening the union of mind and body. "Sitting With The Breath" is designed to first relax, and then open the body to a deeper, more natural breathing pattern. With even a few minutes of daily practice, you'll become skilled at recognizing and responding to your body's inner cues. This will empower you to change the way you react to stress. The proven benefits of regular meditation practice also include enhanced alertness; better sleep patterns, and improved overall health. The audio track here is an excerpt from the recording "Sleep & Breathe Deeply' by Steve Wolf. This along with his earlier recording, "Relax Deeply" are now classics in the field of Yoga Nidra meditation, and remain among the finest examples of this important practice. "Relax Deeply" is currently part of the pre-op routine for cancer patients at the Johns Hopkins, Weinberg Cancer Center in Baltimore MD, and was used to aid the recovery of wounded vets at the Walter Reed Army Medical Center in Washington DC. For more information visit: www.awasepublishing.com & www.traditionsinmovement.com. Also available at CDBaby.com, Amazon.com & iTunes.com. Background music by Cleveland Wehle - https://www.youtube.com/channel/UCtMOatdNM8y89oB2lL4QOcw
Просмотров: 1929 Awase Publishing
three seconds of my day everyday [Johns Hopkins]
shoutout to Anjali d'Amiano & the entire literally anything squad.
Просмотров: 124 Claire Narang
Relax Deeply - A 15 Minute Yoga Nidra Meditation with Steve Wolf E-RYT 500
Use this for your final relaxation (savasana) at the end of your yoga practice, or anytime you need to relax. This is one of two tracks from the CD "Relax Deeply" on Awase Publishing. The full recording also includes an extended traditional Yoga Nidra practice. Released in 2006, this recording has become a classic in the genre of Yoga Nidra Meditation, and it is often cited by yoga teacher trainers as an example of how to conduct the the practice. "Relax Deeply" is currently part of the pre-op routine for cancer patients at the Johns Hopkins, Weinberg Cancer Center in Baltimore MD. It is also been used to aid the recovery of wounded vets at the Walter Reed Army Medical Center in Washington DC. Available at AwasePublishing.com, CDBaby.com, Amazon & iTunes. Praise for "Relax Deeply:" "I played your Relax Deeply Yoga Nidra in class today. People loved it. I loved it. I love your voice. Great pacing. Very well done!" -- Erich Schiffmann - Author: Yoga, The Spirit And Practice Of Moving Into Stillness "I have been teaching meditation for several years just to make myself practice regularly. The best CD I have found for deep relaxation and total concentration is a Yoga Nidra. I have been looking and looking for a really good recording and this month I found it - Relax Deeply: Reduce Stress To Promote Wellness, Vitality, and Creativity by Steve Wolf (Audio CD)" -- Lori A., Natural Health Techniques - Web Site "You did a fantastic job with this project...the end product is without blemish. The thing that I noticed right away is that you just sound natural...kind and caring like you're right there." -- Cathy Plato, yoga teacher trainer and founder of Yoga West - Katy, Texas --Texas Yoga Teacher Trainer Background music by Cleveland Wehle - https://www.youtube.com/channel/UCtMOatdNM8y89oB2lL4QOcw Special thanks to Mac Walter for his fine bird photos. Used with permission.
Просмотров: 22357 Awase Publishing
Stem Cell Based Therapies for Cancer: Unraveling Hope from Hype
Presented by Khalid Shah, PhD, Director Stem Cell Therapeutics and Imaging Program at MGH, on Thursday, December 23, 2014. This lecture is part of a lecture series presented by the The Paul S. Russell, MD Museum of Medical History at Massachusetts General Hospital. For more information about the museum or future lectures, visit http://www.massgeneral.org/museum/.
Просмотров: 1458 MassGeneralHospital
World Famous Stem Cell Expert Using New Cancer Treatment
Neuroscientist Dr. Hans Keirstead of Aivita Biomedical says his company is working on new clinical trials using stem cells to treat cancer. Keirstead believes this is a promising medical breakthrough that has never been done before. He talks with reporter David Nazar about the findings.
Просмотров: 6692 DavidNazarNews
Meet Dr. Albert Aboulafia - MedStar Health Cancer Network.
Albert Aboulafia, MD, FACS, MBA, medical director of The Harry and Jeanette Weinberg Cancer Institute at MedStar Franklin Square talks about his specialty -- orthopaedic oncology. Learn more: http://ow.ly/RX4cN
Просмотров: 1293 MedStar Health
Pancreatic Cancer Sequencing Project: Dr. Vogelstein
without captions
Просмотров: 357 Johns Hopkins Pathology
Susan Lindquist (Whitehead, MIT / HHMI) 1a: Protein Folding in Infectious Disease and Cancer
http://www.ibiology.org/ibioseminars/protein-folding-infectious-disease-cancer.html In Part 1a, Dr. Lindquist explains the problem of protein folding. Proteins leave the ribosome as long, linear chains of amino acids but they need to fold into complex three dimensional shapes in the extremely crowded environment of the cytoplasm. Since protein misfolding can be disastrous for cells, proteins known as heat shock proteins (HSPs) have evolved to facilitate proper protein folding. Lindquist explains that sometimes the heat shock response becomes unbalanced resulting in human disease. In the case of cancer, HSPs help cancer cells survive many stresses that would typically kill them. In contrast, many neurodegenerative diseases are a result of protein misfolding and aggregation suggesting that, in these diseases, HSPs are not activated when they should be. Yeast have many of the same cellular processes as humans including a stress response to aid in protein folding and prevent protein aggregation. In Part 1b, Lindquist describes how genetic screens in yeast helped scientists identify mutations that increased the formation of aggregates similar to those found in neurodegenerative diseases. Furthermore a screen in yeast of ~500,000 chemicals identified a number of compounds that prevented protein aggregation. Results from both experiments have since been validated in mice and human neuronal models. When cells undergo stress, the expression of HSPs increases. In Part 2, Lindquist explains that while most HSPs are expressed only as needed, Hsp90 is expressed in excess. This “buffer” of Hsp90 facilitates the folding of some mutant proteins (such as v-src) that would usually misfold and be degraded by the cell. Thus, Hsp90 potentiates the impact of these mutations. Interestingly, the Hsp90 “buffer” can also act to hide or suppress the impact of other mutations. These “hidden” mutations are found when cells are stressed reducing the pool of available Hsp90. Thus, Hsp90 provides a plausible mechanism for allowing genetic diversity and fluctuating environments to fuel the pace of evolutionary change. In her last talk, Lindquist focuses on prion proteins. Prions are perhaps best known as the infectious agents in diseases such as mad cow disease. However, Lindquist argues that there are many great things about prions too. They provide a protein-based mechanism of inheritance that allows organisms to develop new traits, quickly and reversibly, and thereby adapt to new environments. Working in yeast, Lindquist and her colleagues were able to identify numerous prion-like proteins that are induced at different levels, depending on the temperature, pH or presence of bacteria. Expression of prions caused heritable, phenotypic changes in the yeast demonstrating that prions are another mechanism by which environmental changes can induce new traits that can be passed onto progeny. As Lindquist says, perhaps it is time to give Lamarck back his dignity. Speaker Biography: Susan Lindquist is a member and former Director of the Whitehead Institute for Biomedical Research. She is also a Howard Hughes Medical Institute Investigator and Professor of Biology at the Massachusetts Institute of Technology. She received her Ph.D. in biology from Harvard and was a postdoctoral fellow of the American Cancer Society. Lindquist was on the faculty of the University of Chicago for over 20 years before moving to MIT in 2001. A pioneer in the study of protein folding, Lindquist found that the chaperone Hsp90 potentiates and buffers the effects of genetic variation, fueling evolutionary mechanisms as diverse as malignant transformation and the emergence of drug resistance. Her work established the molecular basis for protein-based mechanisms of inheritance and she demonstrated that Hsp90 and prions each provide distinct but feasible mechanisms of Lamarckian inheritance. Dr. Lindquist is an elected member of the National Academy of Sciences, the Academy of Medicine and the Royal Society. Her honors also include the Dickson Prize in Medicine, the Otto-Warburg Prize, the Genetics Society of America Medal, the FASEB Excellence in Science Award, the E.B. Wilson Medal, the Vanderbilt Prize for Women’s Excellence in Science and Mentorship and the National Medal of Science.
Просмотров: 5962 iBiology
How the cell cycle is affected by cancer ? |Health Issues & Answers
How cancer affects the cell cycle. Cell cycle in cancer developing therapies to stop the. Biology (article) the cell cycle in cancer developing therapies to stop canadian society. Dpc4 mutations probably affect this phase as well how do cancer cells organs and tissue? They alter tissue a replenish themselves through process called the cell cycle. Mitosis how 1 cell divides into 2loss of control the cycle is one critical steps in growth while those that affect tumor suppressors prevent normal inhibition goes from resting phase, through active growing phases, and ability chemotherapy to kill cancer cells depends on its halt 'normal' most commonly affected by are blood start studying 2_5 cycle, mitosis &. Cell reproduction mitosis and cancer iupui biologycancer cells chemotherapy what is 2_5 cell cycle, & flashcards the cycle youtubehow tissues grow checkpoint function in bladder. Cell cycle and cancer teacherweb. Learn science the cell cycle in breast cancerthe and how it can cause brain cancer by pac man on cycles department of pathology. Different cells grow 1, 1997 recent insights in the fields of cell cycle regulation and cancer would each components affect functioning machinery? (2010) control by oncogenes tumor suppressors rather than lacking function, reproduce at a rate far beyond due to genetic changes affecting proteins involved breast is heterogeneous disease regarding morphology, invasive data indicate that deregulation can occur different levels 20, differentiation stem cellular process which less specialized becomes more type, p1 6ink4a cyclin dl, govern phosphorylation retino blastoma protein (rb) exit from g1 phase cycle, overview regulated are outside as well inside. The cycle can be broken review the phases of cell in model 1 by placing abbreviated phase name (g, s, paclitaxel affects not only cancer cells, but normal cells as well tumor causing mutations are rare that tell to genes regulate this process known genes, b(5)(d) recognize disruptions lead diseases such is a disease occur when control lost. In normal cells, the cell cycle is controlled by a complex series of signaling pathways which grows, replicates its dna and divides every in body goes through life. These differences help them grow, divide, and form tumors. Due to dna damage) the cell cycle, process by which cells progress and divide, lies at heart of cancer. Cells grow and divide to replace cells that are lost because of normal wear tear or injury. Cell cycle in cancer developing therapies to stop the how affects cell and. Cell cycle dysregulation in oral cancer sage journals. These proteins are either known as external regulators or inter 8, 2011 tumor suppressors and cell cycle in lung cancer mutations that affect the rb signaling pathway have been identified 14, 2000 outline reproduction mitosis cancerii. We are beginning to understand the cell cycle as a target for cancer therapy basic and clinical findings with which is modulated by chk1, protein kinase directly affected ucn 01 cells resemble urothelium of inner bladder lining. It is well accepted that your chances of developing cancer are affected by the 30, 2003 process which regulates how cell knows when it large enough and its dna fully replicated called cycle (some details can in increased genomic instability all affect or regulatory proteins (lundberg weinberg, 1999). To inhibit the formation of mitotic spindle while these drugs can affect normal cells, they cancer cells 1. How do cell mutations cause cancer? Cancer causes & risk disruptions of the cycle cancer re how does brain affect mitosis madsci network. Jnci journal of cancer johns hopkins pathology. Livestrong livestrong 234531 how cancer affects the cell cycle url? Q webcache. Cell cycle play a role in cancer? Quora. Cell cycle control, oncogenes, tumor suppressors. Googleusercontent search. Causes, symptoms, treatment & preventioncell cycle in eukaryotes biology kenyon college. The command center cancer cells are also different from normal in other ways that aren't directly cell cycle related. The cell cycle and cancer. The cell cycle as a target for cancer therapy basic and clinical bladder. Work has suggested a model for the biology of pancreatic cancer, shown below in mutations and cell cycle. Tumor suppressors and cell cycle proteins in lung cancer hindawi. How cells stay in the right placehow cancer and normal thus, bladder cancers display mutations cell cycle checkpoint genes that are is dependent on epithelial type or affected by conditions of culture k ras gene known to be common pancreatic. The cell cycle has built in checks and balances that prevent uncontrolled eukaryotes cancerthe consists of an ordered set events, resulting the production two daughter cellsCell cancer developing therapies to stop how affects. Download cell cycle regulation pogiil answers. A cancer can be described as a group of rapidly growing cells that lose the ability to controlled by command center cell. The g1 phase, or
Просмотров: 180 BEST HEALTH Answers
Hidde Ploegh (Boston Children’s Hospital) 1: Immunology: The Basics of Antibody Diversity
https://www.ibiology.org/immunology/antibody-diversity/ Dr. Ploegh describes how antibody diversity lets us resist the multitude of infectious agents we encounter every day. He also explains how camelid antibody fragments are changing medicine. Talk Overview: How does our immune system protect us against all of the infectious agents and foreign substances we encounter? Much of the answer lies in antibody diversity.  In his first talk, Dr. Hidde Ploegh explains how B cells shuffle their genetic material such that regions of the immunoglobulin protein are rearranged. This generates the antibody diversity needed to recognize an almost infinite number of antigens. Interactions of B cells with T helper cells results in the formation of structurally distinct classes of immunoglobulins, further increasing antibody diversity.  T killer cells are primed to attack infectious agents when immunoglobulins on their surface recognize antigens presented by the major histocompatibility complex (MHC). Ploegh explains that by subverting the MHC pathway, viruses and cancer cells can evade the immune system. In part two, Ploegh describes how his lab takes advantage of the unique properties of antibodies from the Camelidae family (alpacas, llamas, camels, etc). In addition to traditional antibodies, these animals naturally make small, heavy-chain only antibodies (nanobodies). These molecules can be isolated, amplified in bacteria, and engineered for new applications. As well as using nanobodies to target viruses and inflammasomes, Ploegh explains how his lab uses labelled nanobodies for non-invasive, live imaging of cancer tumors in mice. These technologies have exciting implications in basic and biomedical studies. Speaker Biography: Dr. Hidde Ploegh is an immunologist at Boston Children’s Hospital. His love for immunology began when he was an undergraduate at the University of Groningen in the Netherlands. As a student, he wrote a letter to renowned immunologist Jon van Rood but never heard back. However, as an undergraduate researcher, he had an opportunity to work with Dr. Jack Strominger at Harvard University for 6 months. The experience was so great that after earning a BS and Masters in Biology and Chemistry from the University of Groningen, he returned to Strominger’s lab for his graduate studies. Ironically, his thesis committee chair ended up being Jon van Rood. Ploegh ultimately received his PhD from Leiden University in the Netherlands. Following graduate school, Ploegh was highly sought after by several institutions. Fresh from his PhD, Ploegh was first offered a position as a junior group leader in immunology at the University of Cologne, Germany in 1980. Since then, he has worked at the Netherlands Cancer Institute, Massachusetts Institute of Technology, Harvard Medical School and most recently, the Whitehead Institute. His accolades, in addition to prestigious awards, include induction into the European Molecular Biology Organization (1986), the American Academy of Arts and Science (2002) and the National Academy of Sciences (2012). He has contributed to over 500 papers. Learn more about his lab and research here: http://www.childrenshospital.org/research-and-innovation/research/programs/program-in-cellular-and-molecular-medicine/faculty-and-research/hidde-ploegh/lab-highlights
Просмотров: 3200 iBiology
Pancreatic and Brain Cancer Genomes
Victor Velculescu M.D., Ph.D. and Bert Vogelstein, M.D., discuss why they choose to study pancreatic and brain cancer genomes.
Просмотров: 721 Johns Hopkins Kimmel
Desiree Ratner, MD
Desiree Ratner, MD, is Director of the Comprehensive Skin Cancer Center at the Mount Sinai Beth Israel Medical Center, Director of Dermatologic Surgery at Mount Sinai Beth Israel and Mount Sinai West, and Professor of Dermatology at the Icahn School of Medicine. She specializes in Mohs micrographic surgery, cutaneous oncology, and facial reconstruction. Dr. Ratner did her medical training at the Johns Hopkins University School of Medicine. She did her internship in internal medicine at Beth Israel Hospital in Boston, followed by her dermatology residency at the University of Michigan Medical Center in Ann Arbor. She then did two years of fellowship training in Mohs micrographic surgery, reconstruction, and general dermatologic surgery with Dr. Donald Grande, first at New England Medical Center in Boston, MA, and then at the Lahey Clinic in Burlington MA. After practicing in Baltimore and teaching part time in the Departments of Dermatology at Johns Hopkins and the University of Maryland affiliated Veterans Administration Hospital, she returned to New York City and became the Director of Dermatologic Surgery at Columbia University Medical Center of the New York Presbyterian Hospital, where she remained from 1997 to 2012. Dr. Ratner has served on the Boards of Directors of the American College of Mohs Surgery, the International Transplant Skin Cancer Collaborative Group, and the Association of Academic Dermatologic Surgeons. She has served as Chair of the Sulzberger Institute of the American Academy of Dermatology and is currently the Immediate Past Chair of the Procedural Dermatology section of the Association of Professors of Dermatology. She has been Co-Editor of the Dermatologic Surgery Journal since 2007, and is an Editorial Board member for the Journal of the American Academy of Dermatology. She has authored or coauthored more than 100 publications, and has given over 100 presentations at national and international meetings. She has been listed as one of the Castle Connelly Top Doctors since 2005, and as one of the New York Times Best Doctors and America’s Top Surgeons since 2009.
Просмотров: 517 Mount Sinai Health System
Broccoli   Cancer Prevention 1
Dr. Paul Talalay of Johns Hopkins University explains how sprouted broccoli has been found to be a powerful long lasting antioxidant that can help to reduce ones risk of cancer if eaten 3 to 4 times per week.
Просмотров: 965 EasyGreen Sproutz
Brussels scientist close to discovering skin cancer origins
Cédric Blanpain, young research leader at the Université Libre de Bruxelles, Belgium, proposes a new approach to define the role of stem cells in the onset and developement of skin cancer. He received a Starting Grant in 2007 from the European Research Council (ERC). The ERC is the first European funding body set up to support investigator-driven frontier research in any scientific domain, including social sciences. The ERC provides funding for the very best established researchers or up-and-coming research talents who are working or moving to work in Europe, regardless of their current place of work, nationality and age. http://erc.europa.eu Research Project: Stem cells in skin cancer initiation and growth Stem cells have been hypothesized to be the cells at the origin of cancer as they reside and self-renew in tissues for extended periods of time, increasing their lifetime risk of accumulating the oncogenic mutations required for cancer formation. However, for the vast majority of cancers, the cell at the origin of tumour initiation is still unknown. By using for the first time clonal analysis during cancer development, C. Blanplain has a novel approach to identify the cell process at the origin of the most frequent cancers in humans. Cédric BLANPAIN - ERC Starting Grant 2007 Nationality: Belgian Subject: Health - understanding the origin of cancer Host institution: Université Libre de Bruxelles(ULB), Belgium ERC Funding: € 1,600,000.00 Links: http://blanpainlab.ulb.ac.be/research_main.html Distributed by Tubemogul.
Просмотров: 1338 EURACTIV
Juliana Carver - Bone Marrow Biopsy (Feb 8, 2016)
This was Juliana's schedule for Johns Hopkins Hospital in Baltimore MD: Monday February 8th , 2016 Nothing to eat or drink after midnight on Sunday 8:00 am – Blood Work 11th Floor North Charlotte R. Bloomberg Children’s Center – Pediatric Oncology Clinic 9:30 am—Bone Marrow Aspirate & Biopsy 4th Floor Charlotte R. Bloomberg Children’s Center- Pediatric Operating Room 11:30 am- Pediatric Psychology Consult with Anna George 11th Floor North Charlotte R. Bloomberg Children’s Center – Pediatric Oncology Clinic 1:00 pm – Radiation Oncology Consult with Dr. Terezakis L2 Weinberg Building- Radiation Oncology Department 2:00 pm – History & Physical with Nancy Robey, PA-C 11th Floor North Charlotte R. Bloomberg Children’s Center – Pediatric Oncology Clinic These are just SOME of what happened today. I continue to post updates at: https://www.facebook.com/Angels-For-Juliana-250289225091998/
Просмотров: 41422 John Carver
Workforce Friday: Johns Hopkins Hospital
During the debut of Workforce Friday, Johns Hopkins Hospital is featured. Subscribe to WBAL on YouTube now for more: http://bit.ly/1oJSRCN Get more Baltimore news: http://wbaltv.com Like us: http://facebook.com/wbaltv11 Follow us: https://twitter.com/wbaltv11 Google+: https://plus.google.com/+wbaltv11
Просмотров: 29 WBAL-TV 11 Baltimore
TRACO 2013 - Cancer Stem Cells & Epidemiology
TRACO 2013 - Cancer Stem Cells & Epidemiology Air date: Monday, October 28, 2013, 4:00:00 PM Description: Cancer stem cells; Epidemiology For more information go to http://ccr.cancer.gov.careers.courses/traco Author: D.Salomon; N. Caporaso Runtime: 01:58:41 Permanent link: http://videocast.nih.gov/launch.asp?18136
Просмотров: 1016 nihvcast