For a lot more videos, worksheets, problem sessions and 3D models on chemistry check out Epistemeo. It's FREE. http://www.epistemeo.com In this tutorial we look at how the Fries and Beckmann rearrangements can be used in the synthesis of paracetamol acetaminophen). There are many syntheses of paracetamol, but this one is perhaps the best for looking at and practising reaction mechanisms.
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Drawings and naming organic molecules leads to mass confusion for Biology students, most of whom have not yet taken Organic Chemistry. This video will introduce you to this strange world filled with chains and rings and help you to make sense of it. If you have watched my CHEMISTRY BASICS videos I and II (links below) you are ready for what comes next! By the end of the video you will be able to look at structures for aspirin and caffeine and figure out the chemical formula for each. YES YOU WILL!!! Links to CHEMISTRY BASICS VIDEOS Chemistry Basics Part I: http://youtu.be/MYuh5yErdfA Chemistry Basics Part II: http://youtu.be/Juw7HBg0zZs JOIN THE FUN all over the WEB: SUBSCRIBE: http://www.youtube.com/user/ThePenguinProf FACEBOOK: https://www.facebook.com/ThePenguinProf GOOGLE+: https://plus.google.com/+Penguinprof/posts TWITTER: https://twitter.com/penguinprof WEB: http://www.penguinprof.com/ VIDEO DETAILS: Feel the Power of STRUCTURES Recall: Bonding Rules are based on valence electrons Hydrogen: happy with 1 covalent bond Carbon: happy with 4 covalent bonds Nitrogen: happy with 3 covalent bonds Oxygen: happy with 2 covalent bonds Organic chemistry codifies lots of things: How Many Carbons? Types of Carbon-Carbon Bonds Let's get drawing and understanding: Ethanol: (structure to formula: C2H6O Ethanol has two carbon atoms (eth-) with a single bond between them (-ane), and an attached -OH group (suffix "-ol") RULES: 1. Carbon lives at BENDS and ENDS 2. HYDROGENS bring carbon HAPPINESS Let's try another: Caffeine (structure to formula): C8H10N4O2 And finally: Aspirin: (structure to formula): C9H8O4
Просмотров: 191402 ThePenguinProf
Subscribe Now: http://www.youtube.com/subscription_center?add_user=ehoweducation Watch More: http://www.youtube.com/ehoweducation Calculating the biological half-life of paracetamol is something that you can do with some very specific measurements. Calculate the biological half-life of paracetamol with help from an experienced science professional in this free video clip. Expert: Robin Higgins Filmmaker: bjorn wilde Series Description: Chemistry problems also have very simple and straightforward solutions, as long as you know where to look. Find out about chemistry and science in general with help from an experienced science professional in this free video series.
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also known as acetaminophen, Paracetamol consists of a benzene ring core, substituted by one hydroxyl group and the nitrogen atom of an amide group in the para (1,4) pattern. The amide group is acetamide (ethanamide). It is an extensively conjugated system, as the lone pair on the hydroxyl oxygen, the benzene pi cloud, the nitrogen lone pair, the p orbital on the carbonyl carbon, and the lone pair on the carbonyl oxygen are all conjugated. The presence of two activating groups also make the benzene ring highly reactive toward electrophilic aromatic substitution. As the substituents are ortho, para-directing and para with respect to each other, all positions on the ring are more or less equally activated. The conjugation also greatly reduces the basicity of the oxygens and the nitrogen, while making the hydroxyl acidic through delocalisation of charge developed on the phenoxide anion.
Просмотров: 578 Ismael Baucont C
Visit our website: https://www.m-learning.in Call Us at : (+91)9826023696, 9826023096. Aspirin is toxic for liver and sometimes also causes bleeding from- stomach. So, naproxen, ibuprofen, paracetamol,dichlorofenac sodium are other widely used analgesics. Antipyretics These are the chemical substance which reduce body temperature during high fever. Paracetamol, aspirin, phenacetin (4-hydroxy acetanilide), analgin and novalgin, etc., are common antipyretics. Out of these, paracetamol (4-acetamidophenol) is most common. Antimicrobials An antimicrobial tends to kill or prevent development of microbes CII inhibit the pathogenic action of microbes such as bacteria, fungi and virus selectively. [Sulpha drugs constitute a group of drugs which are derivatives of sulphanilamide and have great antimicrobial capacity, thus, these are widely used against diseases such as dyptheria, dysentry, tubercu losis, etc.] Mail us at :firstname.lastname@example.org Download our app from Google Play Store and App Store
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Copy of your description...-- Created using PowToon -- Free sign up at http://www.powtoon.com/join -- Create animated videos and animated presentations for free. PowToon is a free tool that allows you to develop cool animated clips and animated presentations for your website, office meeting, sales pitch, nonprofit fundraiser, product launch, video resume, or anything else you could use an animated explainer video. PowToon's animation templates help you create animated presentations and animated explainer videos from scratch. Anyone can produce awesome animations quickly with PowToon, without the cost or hassle other professional animation services require.
Просмотров: 185 King James
Aspirin, or acetylsalicylic acid, is one of the oldest and most well-known medications for headaches, fever, pain, and even prevention of heart attack and stroke. How does this drug cause relief of these symptoms? Check out this episode of Medicurio to learn about the quite interesting mechanism of aspirin in the body. Detailed Mechanism of Aspirin: There are two major forms of cyclooxygenase (COX) in cells. COX-1 is always made in the cell, while COX-2 is only made during inflammation. Aspirin permanently inhibits the COX-1 isoform (version) by acetylation of its active site. Therefore, aspirin’s effect lasts however long it takes for the cell to transcribe and translate new COX-1 enzymes, which usually takes a few hours. COX-1 decreases fever, pain, and inflammation, but also increases the risk of gastric ulcers by decreasing clotting and stomach mucous production. The COX-2 isoform is thought to only produce prostaglandins involved in fever, pain, and inflammation but not other functions; therefore, making a drug that inhibits COX-2 instead of COX-1 would give all the anti-inflammatory effects of aspirin without the risk of gastric ulcers. Such a drug would be a major upgrade and many companies came up with possible COX-2 inhibitors. One such drug, called rofecoxib or Vioxx, entered the market claiming that it would not cause gastric ulcers. What the drug company did not reveal was that during clinical trials, many patients suffered from heart attacks after chronic use. These problems began to surface once the general public began using Vioxx, leading to withdrawal of the drug and lawsuits against the company. Moral of the story? Research integrity is important, especially for a drug company as people’s lives are at stake. Trivia about Aspirin: It is debated if Felix Hoffmann was the true “inventor” of aspirin. Arthur Eichengrün, a fellow Bayer employee, claimed that he was the one who came up with the procedure and that Hoffmann simply performed the reaction following his guidelines. Bayer has denied this claim. Hoffmann synthesized aspirin for his father, who complained about the taste of salicylic acid that he was taking to treat his arthritis. Aspirin is extremely toxic to cats (which cannot break down aspirin) and to a lesser extent, dogs. Despite this, aspirin can still be used, just at low doses, to treat inflammation in animals. You can overdose on aspirin – at lethal doses, aspirin interferes with energy production in the mitochondria which leads to eventual death. Before death, unique symptoms such as ringing in the ears, hyperventilation, and dizziness, as well as non-specific symptoms such as vomiting and nausea appear. Overdoses are often due to chronic aspirin use, so if any of these symptoms apply to you, speak to a doctor immediately. Aspirin’s effect is increased by ingesting it with caffeine because caffeine is a stimulant, which increases blood flow to carry aspirin around the body faster and begin acting on tissue quicker. Acetaminophen (Tylenol) is not technically an NSAID because it does not decrease inflammation; however, it also works on COX enzymes so I have lumped it with the other NSAIDs in this video for simplicity.
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The cold medicine you picked up at the store involves some cool chemistry to treat your symptoms. *Correction: This episode was written by Alison Caldwell. Hosted by: Olivia Gordon ---------- Support SciShow by becoming a patron on Patreon: https://www.patreon.com/scishow ---------- Dooblydoo thanks go to the following Patreon supporters: Kelly Landrum Jones, Sam Lutfi, Kevin Knupp, Nicholas Smith, Inerri, D.A. Noe, alexander wadsworth, سلطان الخليفي, Piya Shedden, KatieMarie Magnone, Scott Satovsky Jr, Bella Nash, Charles Southerland, Bader AlGhamdi, James Harshaw, Patrick Merrithew, Patrick D. Ashmore, Candy, Tim Curwick, charles george, Saul, Mark Terrio-Cameron, Viraansh Bhanushali, Kevin Bealer, Philippe von Bergen, Chris Peters, Justin Lentz ---------- Looking for SciShow elsewhere on the internet? Facebook: http://www.facebook.com/scishow Twitter: http://www.twitter.com/scishow Tumblr: http://scishow.tumblr.com Instagram: http://instagram.com/thescishow ---------- Sources: https://www.health.harvard.edu/diseases-and-conditions/common-cold-viral-rhinitis https://library.med.utah.edu/WebPath/INFLHTML/INFL005.html http://www.sciencedirect.com/science/article/pii/S1879729614001665?via%3Dihub http://www.sciencedirect.com/science/article/pii/S1081120610602402?via%3Dihub https://secure.medicalletter.org/TML-article-1484d http://www.cochrane.org/CD009345/ARI_antihistamines-common-cold https://respiratory-research.biomedcentral.com/articles/10.1186/1465-9921-13-98 http://www.tandfonline.com/doi/full/10.3109/01902148.2011.623116 http://www.sciencedirect.com/science/article/pii/S0954611115300640?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/28761581 http://www.sciencedirect.com/science/article/pii/S0163725816000176 https://web.archive.org/web/20121016221008/ http://www.deadiversion.usdoj.gov/drugs_concern/dextro_m/dextro_m.pdf https://www.ncbi.nlm.nih.gov/pubmed/18253996 https://www.ncbi.nlm.nih.gov/pubmed/15231978 Image Sources: https://upload.wikimedia.org/wikipedia/commons/thumb/e/e5/%28%2B%29-Pseudoephedrin.svg/2000px-%28%2B%29-Pseudoephedrin.svg.png https://commons.wikimedia.org/wiki/File:Phenylephrine.png https://images.rxlist.com/images/rxlist/hycotuss2.gif https://commons.wikimedia.org/wiki/Category:Dextromethorphan#/media/File:Dextromethorphan_skeletal.png https://commons.wikimedia.org/wiki/File:Tightjunction_BBB.jpg
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More free chemistry help videos: http://www.nathanoldridge.com/chemistry-videos.html This is the easiest way to figure out how each atom's orbitals are hybridized.
Просмотров: 192442 chemistNATE
Acetaminophen (paracetamol) is an analgesic commonly used as a headache reliever of minor aches & pains but is less effective as an anti-inflammatory medication. While popular for causing less stomach irritation, it can have seriously damage the liver if taken in excessive doses. This molecule was built using the 3d model builder on www.indigo.com
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Convert the following structures into molecular formulas: acetylsalicylic acid, acetaminophen, cocaine.
Просмотров: 739 Professor Heath's Chemistry Channel
Part of NCSSM CORE collection: This video shows the synthesis of aspirin. http://www.dlt.ncssm.edu Please attribute this work as being created by the North Carolina School of Science and Mathematics. This work is licensed under Creative Commons CC-BY http://creativecommons.org/licenses/by/3.0 Help us caption & translate this video! http://amara.org/v/GAf5/
Просмотров: 201558 North Carolina School of Science and Mathematics
Understandings: Aspirin is prepared from salicylic acid. Applications and skills: Explanation of the synthesis of aspirin from salicylic acid, including yield, purity by recrystallization and characterization using IR and melting point. Discussion of how the aspirin can be chemically modified into a salt to increase its aqueous solubility and how this facilitates its bioavailability.
Просмотров: 17601 Mike Sugiyama Jones
Просмотров: 199 AIO Mr. Sonu
UPDATE: In this video, I am showing you guys what the "proper" procedure would be, but it is by no means the fastest. If you want the fastest way, follow chemplayers method. I just prefer to not evaporate solvents, but that takes extra time. I would use a gravity filtration though in both cases though. It's just as fast and doesn't have as many problems as a vacuum one. Still do a recrystallization though. Without a recryst/hot filtration, the ASA is still pretty dirty. Hey guys, today we are starting on the journey from Aspirin to Tylenol. Tell me what you guys wanna see by voting here: http://www.strawpoll.me/11567284 ChemPlayer video: https://youtu.be/oztnjTukbpE My old aspirin extraction video: https://youtu.be/LvYetXXnTmI ------------------------------------------ Patreon: https://www.patreon.com/user?u=2448989&ty=h Facebook: https://www.facebook.com/NileRed1/ Twitter: https://twitter.com/NileRed2 Personal Instagram: https://www.instagram.com/nilered2/
Просмотров: 120911 NileRed
Paracetamol, also known as acetaminophen or APAP, is a medication used to treat pain and fever. It is typically used for mild to moderate pain relief. Evidence for its use to relieve fever in children is mixed. It is often sold in combination with other ingredients such as in many cold medications. In combination with opioid pain medication, paracetamol is also used for more severe pain such as cancer pain and pain after surgery. It is typically used either by mouth or rectally, but is also available intravenously. Effects last between two and four hours. Paracetamol is generally safe at recommended doses. Serious skin rashes may rarely occur, and too high a dose can result in liver failure. It appears to be safe during pregnancy and when breastfeeding. In those with liver disease, it may still be used,, but in lower doses. Paracetamol is classified as a mild analgesic. It does not have significant anti-inflammatory activity and how it works is not entirely clear. Paracetamol was d... http://www.wikividi.com ____________________________________ Shortcuts to chapters: 00:01:41: Fever 00:02:07: Pain 00:02:21: Osteoarthritis 00:03:17: Low back pain 00:03:36: Headaches 00:04:05: Dental use 00:04:54: Other 00:05:26: Patent ductus arteriosus 00:06:07: Adverse effects 00:06:23: Liver damage 00:08:22: Skin reactions 00:08:52: Asthma 00:09:35: Other factors 00:10:21: Overdose 00:13:57: Pregnancy 00:14:39: Mechanism of action 00:15:45: Pharmacokinetics ____________________________________ Copyright WikiVidi. Licensed under Creative Commons. Wikipedia link: https://en.wikipedia.org/wiki/Paracetamol
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Hank makes it all better by explaining the biochemistry of pain -- how it works, why we have it, and how painkillers, whether they're over the counter or heavy-duty prescription bad boys, make the pain go away. ----------- Like SciShow? Want to help support us, and also get things to put on your walls, cover your torso and hold your liquids? Check out our awesome products over at DFTBA Records: http://dftba.com/artist/52/SciShow Or help support us by subscribing to our page on Subbable: https://subbable.com/scishow -- Looking for SciShow elsewhere on the internet? Facebook: http://www.facebook.com/scishow Twitter: http://www.twitter.com/scishow Tumblr: http://scishow.tumblr.com Thanks Tank Tumblr: http://thankstank.tumblr.com SOURCES http://www.nytimes.com/2012/11/18/magazine/ashlyn-blocker-feels-no-pain.html?pagewanted=all&_r=0 http://mentalfloss.com/article/18615/how-do-painkillers-find-kill-pain http://ed.ted.com/lessons/how-do-pain-relievers-work http://www.scientificamerican.com/podcast/episode.cfm?id=snake-venom-contains-potent-painkil-12-10-04 http://www.thepaincenter.com/why-do-we-feel-pain-and-why-does-our-body-react-to-it.html http://www.scientificamerican.com/article.cfm?id=how-do-painkillers-buffer http://www.drugabuse.gov/publications/research-reports/prescription-drugs/opioids/how-do-opioids-affect-brain-body http://www.drugfreeworld.org/drugfacts/painkillers/a-short-history.html http://www.wisegeek.org/what-are-the-different-types-of-painkillers.htm http://www.boots.com/en/Boots-Pharmaceuticals/Boots-Pharmaceuticals-products/Information-about-Boots-Pharmaceuticals/The-invention-of-Ibuprofen/ http://www.nature.com/nrn/journal/v14/n7/full/nrn3529.html http://www.nature.com/nature/journal/v490/n7421/full/nature11494.html
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metabolism is the protective biochemical process by which our bodies alter xenobiotics either enzymatically or nonenzymatically. generally, drug metabolism begins with hydrophobic drug and converts it to a more hydrophilic metabolite to facilitate its elimination. an understanding of the drug metabolism process and the potential outcomes is critical for developing safe and useful pharmaceuticals. drug metabolism can result in one of two products, an inactive metabolite and an active metabolite. inactive metabolites of the drugs basically have no pharmacological activity of the original drug. an example of that would be the hydrolysis of procaine into para aminobenzoic acid and diethylethanolamine which results in the loss of the anesthetic activity of procaine. on the other hand, an active metabolite can mean that a metabolite can retain the same activity of the parent drug, that's apparent when codeine is demthylated to a more active drug which is morphine. however, in some cases we notice a result known as bioactivation where the parent drug is inactive and the metabolite would have a pharmacological activity, in this case the inactive parent drug is called a prodrug. an example of a prodrug is enalapril which has no activity as an antihypertensive, but upon hydrolysis it becomes enalaprilat which is a potent antihypertensive drug. bioactivation of a drug can also lead to toxic metabolites, the widely used acetaminophen has a metabolite that is called n-acetyl-p-benzoquinone imine which is hepatoxic, I explained the mechanism of the toxicity and the antidote in my previous video which I linked in the description below. The liver has the highest concentration of drug-metabolizing enzymes, because of it’s location between the gastrointestinal tract and the systemic circulation. Based on the reactions involved in the metabolism process we can classify the metabolic pathways into phase I metabolism and phase II. Phase I metabolism is characterized as a functionalization reaction, where they add or reveal a functional group by oxidation, reduction, or hydrolysis, hence, leading to increase in overall polarity of the drug which facilitates its excretion in the urine Oxidation is the most common phase I reaction, Cytochrome p450 is a superfamily of oxidases that are responsible for the majority of oxidation reactions, it’s found in very high concentrations in the liver. Oxidation can also happen through alcohol dehydrogenase which is an enzyme that oxidizes alcohols into aldehydes from primary alcohols and to ketones from secondary. Aldehydes can be oxidized from to carboxylic acid by the enzyme aldehyde dehydrogenase. We can see that in the example of the conversion of acetaldehyde to acetic acid in the metabolism of ethanol. Another phase I reaction is the reduction reaction, there are several reductase enzymes common reduction reactions include the reduction of disulfide bonds, in which the disulfides would be reduced to free sulfhydryls. Another reduction reaction is done by the aldo-keto reductases which reduce carbonyl containing compounds back to alcohol in a process opposite to the oxidation done by alcohol dehydrogenase. The last type of phase I metabolism reaction is hydrolysis, hydrolysis is basically the addition of water across a bond resulting in a more water-soluble metabolite. A great example of hydrolysis is ester hydrolysis which is performed by the enzyme esterase found throughout the body, esterase is responsible for the hydrolysis of an ester into a more soluble alcohol or carboxylic acid. Phase II Phase II reactions are commonly called conjugation reaction owing to the fact they add a functional group on the drug for the purpose of increasing its polarity. The conjugation process requires an enzyme generally termed as transferase, that transfers the large polar molecule called a co-factor onto the drug, Examples of phase II reactions: glucuronidation is the most common phase II reaction, glucuronosyltransferase is the enzyme that uses UDP-GA as the cofactor to transfer glucuronic acid to several functional groups like hydroxyl groups, carboxylic acid ,and hydroxylamines. The glucuronic acid adds a significant amount of hydrophilicity to the molecules facilitating it’s excretion process. Another popular reaction is glutathione conjugation which results from the addition of glutathione molecule to an electrophilic substrate. Being a nucleophile glutathione generally acts to detoxify electrophiles. Glutathione-s-transferase is the enzyme responsible for the reaction of glutathione with electrophiles like epoxides and halides. After the conjugation, the product is excreted as mercapturic acid in the urine. Paracetamol antidote video: https://www.youtube.com/watch?v=hg_gpWjWsRM
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View full lesson: http://ed.ted.com/lessons/how-do-pain-relievers-work Some people take aspirin or ibuprofen to treat everyday aches and pains, but how exactly do the different classes of pain relievers work? Learn about the basic physiology of how humans experience pain, and the mechanics of the medicines we've invented to block or circumvent that discomfort. Lesson by George Zaidan, animated by Augenblick Studios.
Просмотров: 1883073 TED-Ed
UV Visible spectroscopy explained lecture - This lecture explains about the UV visible spectroscopy technique.This explains how colorimetric analysis of samples are done using the transmittance and absorbance of the sample molecule using beer Lambert law. UV vis spectroscopy is used to identify the concentration of the test sample. Here I also explained the beer lambert law and how beer lambert law is derived. For more information, log on to- http://www.shomusbiology.com/ Get Shomu's Biology DVD set here- http://www.shomusbiology.com/dvd-store/ Download the study materials here- http://shomusbiology.com/bio-materials.html Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology- Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching We are social. Find us on different sites here- Our Website – www.shomusbiology.com Facebook page- https://www.facebook.com/ShomusBiology/ Twitter - https://twitter.com/shomusbiology SlideShare- www.slideshare.net/shomusbiology Google plus- https://plus.google.com/113648584982732129198 LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661 Youtube- https://www.youtube.com/user/TheFunsuman Thank you for watching the video lecture on UV Vis spectroscopy.
Просмотров: 277698 Shomu's Biology
In this video we will go through some IR spectra and figure out what they are! You can pause the video, practice figuring them out, then unpause and hear how we know what functional groups each molecule contains. IR Video links http://orgchem.colorado.edu/hndbksupport/irtutor/estersir.html http://www.chem.ucla.edu/~webspectra/irtable.html http://orgchem.colorado.edu/hndbksupport/irtutor/carbonylsir.html http://orgchem.colorado.edu/hndbksupport/irtutor/analyzeir.html
Просмотров: 431652 Sarutahiko1
CHEM 1050 MODERN ELECTROCHEMICAL ANALYSIS FALL 2017
Просмотров: 78 vinh hoang
The molecules are very similar -- you need to know that they all contain a tertiary amine. But there are subtle differences which you need to be able to identify (you will be allowed to use the data booklet which has the structures). Morphine can be turned to heroin by warming with ethanoic acid and using a sulphuric acid catalyst. Don't do this.
Просмотров: 45386 Richard Thornley
The modern pharmacology of paracetamol therapeutic actions mechanisms action and related analgesics mechanism brands dosage slideshare. However, the in vivo effects of paracetamol are similar to those selective cyclooxygenase 2 (cox 2) inhibitors acta pol pharm. J wiak bebenista m, nowak jz. Mechanism of action paracetamol. It is surprising that after more than 100 years, the exact mechanism of action paracetamol remains to be determined 28 oct 2011 drugs worldwide. Paracetamol (acetaminophen) is generally considered to be a weak inhibitor of the synthesis prostaglandins (pgs). The main hypothesis is that paracetamol (also known as acetaminophen in the us) inhibits cox enzyme, and more specifically despite similarities to nsaids, mode of action has been uncertain, but it now generally accepted 1 2 apart from lack anti inflammatory effect rheumatoid arthritis, clinical effects salicylate are very similar 9 mar 2015 presentation illustrates mechanism (nsaids) available brands dosage ibuprofen 22 aug 2008 tissue damage, release pyrogens phospholipids cell membrane archidonic acid nsaid block higher doses may also have ability prevent platelets crossover study evaluate 10 oct 2013 mechanisms. Its therapeutic effects are similar to salicylates, but it we don't know for sure. Mechanism of action paracetamol mechanism paracetamol. 2014 jan feb;71(1) 11 23. It has analgesic properties comparable to those of aspirin, while its anti inflammatory effects are weaker paracetamol pharmacology. These findings finally explain the mechanism of action paracetamol and. Although it is commonly stated that paracetamol acts centrally, a central mechanism of action for has been proposed (13,14). Paracetamol (called acetaminophen in the usa) is a derivative of its mechanism action not clearly established. What is the mechanism of action paracetamol? Quora. Mechanisms of action acetaminophen full text view paracetamol mechanisms and updates oxford academic. Paracetamol concentrations in the cerebrospinal fluid mirror response to fever paracetamol produces analgesia mouse writhing test through a central action which is paralleled by reduction brain pge2. Gov pubmed 24779190 acta pol pharm. Despite its extensive use, mode of action is still unclear. Onstrating that the analgesic effect of paracetamol is due to indirect binoid. Cox 3 and the mechanism of action paracetamol acetaminophen study reveals principal for paracetamolparacetamol wiley online library. Paracetamol mechanism of action, applications and safety concern. In contrast 23 nov 2011 researchers at king's college london have discovered how one of the most common household painkillers works, which could pave way 14 sep 2016. Gov pubmed 15662292 mechanism of action paracetamol. J wiak bebenista m, nowak jz paracetamol can relieve pain in mild arthritis, but has no effect on the underlying inflammation, redness, and swelling of joint. Mechanism of action paracetamolmechanism paracetamolparacetamol mechanism actio
Просмотров: 380 Uco Uco
This video explains some of the chemistry behind codeine - which is an over-the-counter pain medication here in the UK. Recently, media attention has questioned whether codeine should be banned. As usual, this video tries to address the chemistry behind the story, discussing the mode of action of codeine, and how it relies on metabolic activation, which can vary between individuals. I reflect on how the benefits and risks of codeine may be balanced. There is a tutorial to support this video available on my YouTube channel. Music by Marillion (Happiness is the Road).
Просмотров: 53407 ProfessorDaveatYork
Paracetamol, also known as acetaminophen or APAP, is a medication used to treat pain and fever. It is typically used for mild to moderate pain.There is poor evidence for fever relief in children. It is often sold in combination with other ingredients such as in many cold medications. In combination with opioid pain medication, paracetamol is used for more severe pain such as cancer pain and after surgery. It is typically used either by mouth or rectally but is also available intravenously.Effects last between two and four hours. Paracetamol is generally safe at recommended doses.Serious skin rashes may rarely occur.Too high a dose can result in liver failure. It appears to be safe during pregnancy and when breastfeeding.In those with liver disease, it may still be used, but lower doses should be taken. Paracetamol is classified as a mild analgesic.It does not have significant anti-inflammatory activity and how it works is not entirely clear. Paracetamol was discovered in 1877.It is the most commonly used medication for pain and fever in both the United States and Europe.It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system.Paracetamol is available as a generic medication with trade names including Tylenol and Panadol among others.The wholesale price in the developing world is less than 0.01 USD per dose.In the United States it costs about 0.04 USD per dose.
Просмотров: 446 Anika Ahsan
Dear friends, We would like to share with you another module in medicinal chemistry tutorial of the OSDD JSF e-learning series.It would be highly useful to the organic chemists to check Drug Likeness of the molecule. In this module you can analyse various rules considered for drug likeness prediction while the side chain of the compound has changed.Different substitution for Paracetamol is given as example. In order to compare the results please use the help file. Please note that this server will work only on internet explorer.
Просмотров: 1584 nufail m
This is a video of the synthesis of the drug, Ibuprofen.
Просмотров: 190 Miss Master Builder
This is aimed at students in the first and second year of the new linear OCR A chemistry Alevel. The molecule capsaicin is found in pepper spray and is the heat associated with a chilli pepper! We take a look how the A level reactions and mechanisms could help us synthesise it in the lab.
Просмотров: 1218 ASFC Chemistry
Simple: 1) Find the most absorbed wavelength in your sample using a spectrometer. 2) Accurately measure the colour of multiple concentrations of your sample. 3) Plot a graph of concentration against concentration -- tah dah you have a calibration curve based on the Beer-Lambert Law. Now you can find the unknown concentrations of other samples. Tricky: Absorbance = log Io/ I = elc where Io= intensity of incoming light I=intensity of outgoing light e= constant for the substance l =path length of light through the substance c=concentration of substance It's in the data book!
Просмотров: 108809 Richard Thornley