Dr. Thomas Saba, pediatric pulmonologist, presents best practices for primary care providers in the care of pediatric patients with asthma. Presented at the 2018 Partners in Pediatric Care CME. Learn more about University of Michigan C.S. Mott Children's Hospital's services for children with asthma at https://www.mottchildren.org/conditions-treatments/peds-respiratory-care/asthma
Просмотров: 1051 Michigan Medicine
It is made more confusing because there are several other words people use to describe it (difficult, when the diagnosis of asthma confirmed and comorbidities addressed, severe defined as that requires treatment with high dose inhaled 21 nov 2015 in making a decision about child's severity level, first distinction be whether your child has intermittent (ie, just based on disease. Doctors don't know why some people get severe asthma attacks. Uk severe asthma what is url? Q webcache. Learn more about severe asthma acute is an exacerbation of that does not respond to standard treatments bronchodilators (inhalers) and steroidsbackground or therapy resistant increasingly recognised as a major unmet need. So, what is 12 dec 2014 the diagnosis and treatment of severe asthma time consuming requires special experience. What is severe asthma? Asthma asthma definition, diagnosis and treatment ncbi niheveryday healthsevere guidelines american thoracic societyasthma society of ireland. But if you have a severe asthma diagnosis, the inflammation and sensitivity of your airways is likely to be worse lot time, so may need steroid tablets along with inhalers, in long term, help keep this under control around 17 per cent people often symptoms frequent attacks. It may be more likely if you don't often see your doctor, 4 nov 2015 in order to better help these asthmatics, researchers now categorize them under a special asthma subtype called severe. However, even people with intermittent or mild asthma can have severe attacks 31 mar 2016 around 5. Severe asthma is defined as that requires treatment with high doses of inhaled or systemic corticosteroids to prevent it from becoming uncontrolled 20 oct 2016 symptoms. One medicine commonly used to reduce inflammation in the airways is steroids. The natural history of acute decompensations is one resolution and only 31 mar 2016 an exacerbation asthma serious can even become life threatening. Severe brittle asthma and status asthmaticus mild, moderate, severe what do grades mean classifying severity foundation there is a difference between attack symptoms causes mayo clinic. Asthma may be classified as intermittent, mild persistent, moderate and severe persistent. What is severe asthma? What 'difficult to control' asthma status asthmaticus (severe attacks) symptoms and webmd. Acute severe asthma american journal of respiratory and critical acute exacerbation what are the symptoms? Healthlineis serious? Asthma sharecare. There is a need for competent treatment 30 may 2017 about 24 million americans have asthma, and some, the condition can be severe. Asthma attack signs and symptoms include severe shortness of breath, chest tightness or pain, coughing wheezing; Low 20 aug 2002 acute asthma remains a major economic health burden. What is severe asthma? . More rarely, you might have a specific type of asthma called 'severe' asthma' causes. That's why it's important to recognize the symptoms early what is severe asthma? Though p
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This is a recording of a recent webinar in which Renato Testi MD, Medical Leader at CROMSOURCE discusses the development of LAMA therapy for the treatment of Asthma and COPD. Also the webinar discusses the use of DLCO monitoring.
Просмотров: 271 CROMSOURCE
To access this issue of Topics in Focus: http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1440-1843/homepage/seeking_innovative_solutions_for_severe_asthma.htm Seeking innovative solutions for severe asthma Series Editors: Vanessa McDonald, Peter Gibson and Steven Maltby The purpose of the series editors for this series ‘Seeking Innovative Solutions in Severe Asthma’ was to generate discussion and interest in novel and innovative severe asthma research and clinical practice. The series opens with a review reporting the outcome of a roundtable discussion on current management, targeted therapies and future directions, with each of these aspects being then covered in subsequent reviews of the series in both adults and children. The series editors are optimistic and excited to present the latest developments in the treatment of severe asthma and their potential to improve the lives of patients with this difficult disease. We hope that you will share their vision and enthusiasm through their review series. McDonald, V.M., Maltby, S. and Gibson, P.G. (2016) Severe asthma: Can we fix it?. Respirology, 22: 19–20. doi: 10.1111/resp.12956. McDonald, V.M., Maltby, S., Reddel, H.K., King, G.G., Wark, P.A.B., Smith, L., Upham, J.W., James, A.L., Marks, G.B. and Gibson, P.G. (2016) Severe asthma: Current management, targeted therapies and future directions—A roundtable report. Respirology, 22: 53–60. doi: 10.1111/resp.12957. Fricker, M., Heaney, L.G. and Upham, J.W. (2017) Can biomarkers help us hit targets in difficult-to-treat asthma?. Respirology, 22: 430–442. doi: 10.1111/resp.13014. Porsbjerg, C. and Menzies-Gow, A. (2017) Co-morbidities in severe asthma: Clinical impact and management. Respirology, 22: 651–661. doi: 10.1111/resp.13026. Maltby, S., Tay, H.L., Yang, M. and Foster, P.S. (2017) Mouse models of severe asthma: Understanding the mechanisms of steroid resistance, tissue remodelling and disease exacerbation. Respirology, 22: 874–885. doi: 10.1111/resp.13052. Bush, A., Fleming, L. and Saglani, S. (2017) Severe asthma in children. Respirology, 22: 886–897. doi: 10.1111/resp.13085. Clark, V.L., Gibson, P.G., Genn, G., Hiles, S.A., Pavord, I.D. and McDonald, V.M. (2017) Multidimensional assessment of severe asthma: A systematic review and meta-analysis. Respirology, 22: 1262–1275. doi: 10.1111/resp.13134. King, G.G., James, A., Harkness, L. and Wark, P.A.B. (2018) Pathophysiology of severe asthma: We’ve only just started. Respirology, 23: 262–271., doi: 10.1111/resp.13251. McDonald, V.M., Maltby, S. and Gibson, P.G. (2018) Severe asthma: We can fix it? We can try!. Respirology, 23: 260–261., doi: 10.1111/resp.13249. Music: Deliberate Thought by Kevin MacLeod is licensed under a Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) Source: http://incompetech.com/music/royalty-free/?keywords=deliberate+thought Artist: http://incompetech.com/
Просмотров: 47 Respirology Video
Learn about important pathophysiologic and clinical considerations in the ICU management of patients with asthma. Please visit: www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user. For further information on how to enroll, please email: firstname.lastname@example.org Please note: OPENPediatrics does not support nor control any related videos in the sidebar, these are placed by Youtube. We apologize for any inconvenience this may cause.
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This a review from the Journal of Allergy and Clinical Immunology. It reviews how using the correct asthma medication and using appropriate asthma treatment will prevent asthma attacks or asthma exacerbations. Using inhaled corticosteroids, long acting beta agonists and leukotriene antagonists will control asthma inflammation and eosinophils. The goal is to have great asthma control and that will result in less asthma symptoms and attacks. This will reduce the need for oral steroids, like prednisone. It will also prevent or reduce asthma emergency room visits and asthma hospitalizations.
Просмотров: 1313 America's Allergist
Learn how spirometry can help prevent medical crises among patients with asthma and chronic obstructive pulmonary disease. Read more: http://www.chcf.org/events/2012/cin-webinar-03-28-2012
Просмотров: 369 California Health Care Foundation
Pediatric Journal Club Presented by: Charles Davis, MD, Pediatric Resident, PGY-3 Rachelle Dykstra, MD, Pediatric Resident, PGY-a Silvia Natalia Jaimes Ocaziones, MD, Pediatrician Carilion Children's The Journal Club Objectives: 1. Practice formulating a specific clinical question and understand the study design most likely to yield valid information about diagnostic questions using the PICO-TT format 2. Appraise the article and understand the uses and limitations of a diagnostic study with the help of the CAT (critical appraisal tool) format for diagnostic accuracy studies 3. Discuss and contextualize the concepts of correlation, Bland-Altman plot, sensitivity and specificity, positive and negative likelihood ratios 4. Distinguish important factors in the determination of internal validity of a diagnostic study 5. Determine the external validity of the article and its applicability in a clinical practice Category 1 CME credit has been approved for this enduring material from January 1 through December 31st, 2019. To receive CME credit for watching this video please complete the survey posted below. Note you will need to answer 2 content questions that are listed at the end of this video in the survey. http://carilion.ca1.qualtrics.com/SE/?SID=SV_3mXTHH0qnxdUsyp
Просмотров: 19 Carilion Children's Outreach Education
On the occasion of the first WAidid Congress, Professor Roche speaks about inhaler treatments in asthma and COPD, the importance of the correct diagnosis and the proper choise of treatment, following the guidelines and considering the right combination of both the pharmacological agent and the device, that is crucial to get the full effectiveness of the treatment. Professor Roche underlines also the importance of teaching to asthma and COPD patients how to use the device properly, that is really important for the adherence to therapy.
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In research published online by the New England Journal of Medicine at the same May 21, 2013 time when Sally Wenzel, M.D., was presenting her findings to the annual meeting of the American Thoracic Society. Wenzel and scientists from the University of Pittsburgh School of Medicine plus other national study sites found an experimental, lab-made molecule was able to stick to certain inflammatory proteins and reduce acute breathing problems among people with a type of moderate-to-severe asthma. For more, visit: http://http://www.asthmainstitute.pitt.edu/
Просмотров: 1489 UPMC
Early signs of loss of asthma control can signal an impending exacerbation. Escalation of treatment has been considered as a way to prevent full-blown exacerbations, but evidence to support this approach is limited. New research findings are summarized in this short video. Watch more Quick Take videos: http://nej.md/quick-take
Просмотров: 1948 NEJMvideo
Differential Diagnosis and Comprehensive Management Strategies Faculty: Sidney S. Braman, MD, FCCP, Reynold A. Panettieri, Jr, MD, James F. Donohue, MD The goal of this activity is to highlight new guidelines for diagnosis of migraine headaches and review treatment strategies for specific patient subtypes, particularly those who experience concomitant gastrointestinal distress. At times, gastrointestinal distress can prevent patients from using their acute medications or reduce the efficacy of oral agents, which means that treatment must be tailored to individual patients and presence of symptoms over time. Patient-centered care based on a comprehensive evaluation of migraine attacks, medical history, and patient preferences, along with the importance of routine follow-up, will be discussed in this engaging, case-based Clinical Research Updates™. View this program in its entirety here http://www.exchangecme.com/ACOSWebcast. You can also visit http://www.ExchangeCME.com for access to additional video content as well as free CME activities in various therapeutic areas.
Просмотров: 224 Integritas Communications
Join Dr. Seheult of https://www.medcram.com as he breaks down the (ACC/AHA) 2017 hypertension guidelines that replace the previous JNC 7 guidelines from 2003. This video Includes: - A comparison to the previous hypertension guidelines (JNC 7 vs the 2017 ACC/AHA guidelines) - The new classification of "elevated blood pressure" - Diet and lifestyle changes for high blood pressure - HTN medications (ACE-I, ARB, beta blockers, calcium channel blockers, diuretics). Visit https://www.MedCram.com for medical courses and over 100 free lectures. Our website is the home for ALL MedCram medical videos (many medical videos, medical lectures, and quizzes are not on YouTube). Speaker: Roger Seheult, MD Co-Founder of MedCram.com (https://www.medcram.com) Clinical and Exam Preparation Instructor Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine. MedCram: Medical education topics explained clearly including: Respiratory lectures such as Asthma and COPD. Renal lectures on Acute Renal Failure and Adrenal Gland. Internal medicine videos on Oxygen Hemoglobin Dissociation Curve and Medical Acid Base. A growing library on critical care topics such as Shock, Diabetic Ketoacidosis (DKA), and Mechanical Ventilation. Cardiology videos on Hypertension, ECG / EKG Interpretation, and heart failure. VQ Mismatch and Hyponatremia lectures have been popular among medical students and physicians. The Pulmonary Function Tests (PFTs) videos and Ventilator associated pneumonia bundles and lectures have been particularly popular with RTs. NPs and PAs have given great feedback on Pneumonia Treatment and Liver Function Tests among many others. Many nursing students have found the Asthma and shock lectures very helpful. Subscribe to the official MedCram.com YouTube Channel: https://www.youtube.com/subscription_center?add_user=medcramvideos Recommended Audience - medical professionals and medical students: including physicians, nurse practitioners, physician assistants, nurses, respiratory therapists, EMT and paramedics, and many others. Review and test prep for USMLE, MCAT, PANCE, NCLEX, NAPLEX, NBDE, RN, RT, MD, DO, PA, NP school and board examinations. More from MedCram.com medical videos: MedCram Website: https://www.medcram.com Facebook: https://www.facebook.com/MedCram Google+: https://plus.google.com/u/1/+Medcram Twitter: https://twitter.com/MedCramVideos Produced by Kyle Allred PA-C Please note: MedCram medical videos, medical lectures, medical illustrations, and medical animations are for medical education and exam preparation purposes, and not intended to replace recommendations by your doctor or health care provider.
Просмотров: 57689 MedCram - Medical Lectures Explained CLEARLY
Dr. M. Hassan Murad, a physician in the Division of Preventive Medicine at Mayo Clinic in Rochester, MN, offers insights into his article appearing in the February 2018 issue of Mayo Clinic Proceedings, on Fractional Exhaled Nitric Oxide Testing, another tool for more accurately diagnosing asthma. He notes clinicians still need to depend on patient’s history, exam, and response to treatment to corroborate the diagnosis, but use of FENO can help in making this challenging diagnosis. Available at: https://tinyurl.com/y8f695xs
Просмотров: 745 Mayo Proceedings
Webinar Presenter: Jeff Callard, PA-C, Department of Emergency Medicine, St. Joseph Mercy Hospital When: December 21, 2016 Goal: The SWBAT identify increase their proficiency in their ability to assess, manage, and treat asthmatic patients. Objectives: The SWBAT correctly identify the underlying pathophysiology of asthma as discussed throughout the presentation. The SWBAT correctly describe the treatment of acute asthma as discussed throughout the presentation. The SWBAT correctly describe treatment strategies for the crashing asthmatic as discussed during the presentation. The SWBAT correctly distinguish key findings of patients suffering from mild to severe asthma, as discussed in the presentation.
Просмотров: 118 MC RH
Related Links: New Stroke Guidelines Extend Thrombectomy to 24 Hours: https://www.medscape.com/viewarticle/891786 Journal Guidelines: http://stroke.ahajournals.org/content/early/2018/01/23/STR.0000000000000158 Arefa Cassoobhoy explains the new stroke treatment guidelines released by the American Heart Association and American Stroke Association after the success seen in two new trials, DEFUSE-3 and Dawn.
Просмотров: 327 Medscape
Video 1 shows the steps for prone positioning of patients with ARDS who are receiving mechanical ventilatory support in the intensive care unit. Video 2 shows the steps for moving the patient who is undergoing mechanical ventilation from the prone to the supine position. See the NEJM article: http://www.nejm.org/doi/full/10.1056/NEJMoa1214103
Просмотров: 515588 NEJMvideo
An overview of Midazolam pharmacology. Twitter: @pmedicresource Email: email@example.com Website: www.paramedicresource.ca References: Reuser T, Flanagan DW, Borland C, Bannerjee DK. Acute angle closure glaucoma occurring after nebulized bronchodilator treatment with ipratropium bromide and salbutamol. Journal of the Royal Society of Medicine. 1992;85(8):499-500. Coakes RL, Siah PB. Effects of adrenergic drugs on aqueous humour dynamics in the normal human eye. I. Salbutamol. The British Journal of Ophthalmology. 1984;68(6):393-397. Scullion JE. The development of anticholinergics in the management of COPD. International Journal of Chronic Obstructive Pulmonary Disease. 2007;2(1):33-40.
Просмотров: 6225 Paramedic Resource
This video “Acute Sinusitis” is part of the Lecturio course “Infectious Diseases” ► WATCH the complete course on http://lectur.io/acutesinusitis ► LEARN ABOUT: - Acute Sinusitis: Definition and Pathology - Consequences of Sinus Ostia Obstruction - Acute Sinusitis: Microbiology and Epidemiology - Signs and Symptoms - Diagnosis - Acute Sinusitis: Management ► THE PROF: Your tutor is Dr. John Fisher, who is certified by the American Board of Internal Medicine in both Medicine and Infectious Diseases. In his 30 years on the faculty of the Medical College of Georgia he has received multiple awards for his excellent teaching. Dr. Fisher is also the author of 61 original publications in refereed journals and 44 book chapters. ► LECTURIO is your single-point resource for medical school: Study for your classes, USMLE Step 1, USMLE Step 2, MCAT or MBBS with video lectures by world-class professors, recall & USMLE-style questions and textbook articles. Create your free account now: http://lectur.io/acutesinusitis ► INSTALL our free Lecturio app iTunes Store: https://app.adjust.com/z21zrf Play Store: https://app.adjust.com/b01fak ► READ TEXTBOOK ARTICLES related to this video: Upper Respiratory Tract Infection (URI, URTI) — Symptoms and Treatment http://lectur.io/acutesinusitisarticle ► SUBSCRIBE to our YouTube channel: http://lectur.io/subscribe ► WATCH MORE ON YOUTUBE: http://lectur.io/playlists ► LET’S CONNECT: • Facebook: https://www.facebook.com/lecturio.medical.education.videos • Instagram: https://www.instagram.com/lecturio_medical_videos • Twitter: https://twitter.com/LecturioMed
Просмотров: 1445 Lecturio Medical Education
This special live webinar on "Thunderstorm Asthma" was hosted by the Centre of Excellence in Severe Asthma (www.severeasthma.org.au). This webinar is in response to the thunderstorm that hit Melbourne during the afternoon of 21st November 2016, which lead to an acute spike in asthma symptoms for many people. This tragically resulted in the loss of eight lives. On behalf of the Centre of Excellence in Severe Asthma we offer our sincere condolences to the families who lost loved ones. This seminar provides insight into what causes thunderstorm asthma and treatment and management strategies to improve patient outcomes. It focuses attention of the questions that need to be addressed, particularly around the mechanisms, prevention and control. The webinar was presented by Professor Guy Marks (UNSW, Woolcock Institute of Medical Research, Liverpool Hospital and the CRE severe asthma). Prof Marks is a respiratory physician and respiratory and environmental epidemiologist. His research focuses on causes, risk factors and prevention of lung disease and monitoring disease burden and management practices. He has pioneered work on measuring quality of life in people with asthma and described the importance of “thunderstorm asthma”. This webinar was hosted by the NHMRC CRE in Severe Asthma on 02 December 2016.
Просмотров: 453 SevereAsthmaCRE
Asthma Management: A case study of HealthNHand Webinar Jointly Presented by Sheena Cherian, PharmD Manager, Drug Therapy Management, PerformRx & Amos Adler, M.Sc President & Co-Founder of MEMOTEXT for the ACAP (Association for Community Affiliated Plans) Vendor Education Series 2015.
Просмотров: 190 MEMOTEXT PATIENCE ADHERENCE
Studies have shown that triple inhaled therapy has benefits in patients at risk for frequent or severe COPD exacerbations, but the therapy has required the use of multiple inhalers several times a day. Full study: https://nej.md/2I6BfjW Watch more Quick Take videos: http://nej.md/quick-take
Просмотров: 3111 NEJMvideo
Acute kidney injury (also called acute renal failure) nursing NCLEX review lecture on the nursing management, stages, pathophysiology, and causes (prerenal, intrarenal, postrenal). What is Acute Kidney Injury? It is the SUDDEN decrease in renal function that leads to the build up of waste in the blood, fluid overload, and electrolyte imbalances. What are the causes of Acute Kidney Injury? There are three causes, which are based on location. The first is known as prerenal injury and this is an issue with the perfusion to the kidneys that leads to decreased renal function. A second cause is known as intrarenal injury, and this is due to damage to the nephrons of the kidney. Lastly, postrenal injury is due to a blockage located in the urinary tract after the kidney that can extend to the urethra. This is causing the back flow of urine, which increases the pressure and waste in the kidneys. Stages of Acute Kidney Injury: There are four stage of acute kidney injury, which include initiation, oliguric, diuresis, and recovery stage. The initiation stage starts when a cause creates an injury to the kidney and then signs and symptoms start to appear. This leads to the oliguric stages. The patient will void less than 400 mL/day of urine during this stage and will experience increased BUN/creatinine levels, azotemia, hyperkalemia, hypervolemia, increase phosphate and decreased calcium levels along with metabolic acidosis. After this stage the patient can progress to the diuresis stage and this is where the patient will void 3-6 Liters of urine per day due to osmotic diuresis. The patient is at risk for hypokalemia, dehydration, and hypovolemia. The last stage is recovery and the patient's glomerular filtration rate has returned to normal. Therefore, the kidneys are able to maintain normal BUN and creatinine levels, electrolyte, and water levels. Quiz on Acute Kidney Injury: http://www.registerednursern.com/acute-kidney-injury-nclex-practice-questions/ Notes: http://www.registerednursern.com/acute-kidney-injury-renal-failure-nclex-review/ More NCLEX Renal Lectures: https://www.youtube.com/playlist?list=PLQrdx7rRsKfXkfh1nWrtxLcRTrohj41su Subscribe: http://www.youtube.com/subscription_center?add_user=registerednursern Nursing School Supplies: http://www.registerednursern.com/the-ultimate-list-of-nursing-medical-supplies-and-items-a-new-nurse-student-nurse-needs-to-buy/ Visit our website RegisteredNurseRN.com for free quizzes, nursing care plans, salary information, job search, and much more: http://www.registerednursern.com Check out other Videos: https://www.youtube.com/user/RegisteredNurseRN/videos All of our videos in a playlist: https://www.youtube.com/watch?v=pAhHxt663pU&list=PLQrdx7rRsKfXMveRcN4df0bad3ugEaQnk Popular Playlists: NCLEX Reviews: https://www.youtube.com/playlist?list=PLQrdx7rRsKfWtwCDmLHyX2UeHofCIcgo0 Fluid & Electrolytes: https://www.youtube.com/playlist?list=PLQrdx7rRsKfWJSZ9pL8L3Q1dzdlxUzeKv Nursing Skills: https://www.youtube.com/playlist?list=PLQrdx7rRsKfUhd_qQYEbp0Eab3uUKhgKb Nursing School Study Tips: https://www.youtube.com/playlist?list=PLQrdx7rRsKfWBO40qeDmmaMwMHJEWc9Ms Nursing School Tips & Questions" https://www.youtube.com/playlist?list=PLQrdx7rRsKfVQok-t1X5ZMGgQr3IMBY9M Teaching Tutorials: https://www.youtube.com/playlist?list=PLQrdx7rRsKfUkW_DpJekN_Y0lFkVNFyVF Types of Nursing Specialties: https://www.youtube.com/playlist?list=PLQrdx7rRsKfW8dRD72gUFa5W7XdfoxArp Healthcare Salary Information: https://www.youtube.com/playlist?list=PLQrdx7rRsKfVN0vmEP59Tx2bIaB_3Qhdh New Nurse Tips: https://www.youtube.com/playlist?list=PLQrdx7rRsKfVTqH6LIoAD2zROuzX9GXZy Nursing Career Help: https://www.youtube.com/playlist?list=PLQrdx7rRsKfVXjptWyvj2sx1k1587B_pj EKG Teaching Tutorials: https://www.youtube.com/playlist?list=PLQrdx7rRsKfU-A9UTclI0tOYrNJ1N5SNt Dosage & Calculations for Nurses: https://www.youtube.com/playlist?list=PLQrdx7rRsKfUYdl0TZQ0Tc2-hLlXlHNXq Diabetes Health Managment: https://www.youtube.com/playlist?list=PLQrdx7rRsKfXtEx17D7zC1efmWIX-iIs9
Просмотров: 321674 RegisteredNurseRN
Video abstract of review paper “Applying the wisdom of stepping down inhaled corticosteroids in patients with COPD: a proposed algorithm for clinical practice” published in the International Journal of Chronic Obstructive Pulmonary Disease by Kaplan. Abstract: Current guidelines for the management of chronic obstructive pulmonary disease (COPD) recommend limiting the use of inhaled corticosteroids (ICS) to patients with more severe disease and/or increased exacerbation risk. However, there are discrepancies between guidelines and real-life practice, as ICS are being overprescribed. In light of the increasing concerns about the clinical benefit and long-term risks associated with ICS use, therapy needs to be carefully weighed on a case-by-case basis, including in patients already on ICS. Several studies sought out to determine the effects of withdrawing ICS in patients with COPD. Early studies have deterred clinicians from reducing ICS in patients with COPD as they reported that an abrupt withdrawal of ICS precipitates exacerbations, and results in a deterioration in lung function and symptoms. However, these studies were fraught with numerous methodological limitations. Recently, two randomized controlled trials and a real-life prospective study revealed that ICS can be safely withdrawn in certain patients. Of these, the WISDOM (Withdrawal of Inhaled Steroids During Optimized Bronchodilator Management) trial was the largest and first to examine stepwise withdrawal of ICS in patients with COPD receiving maintenance therapy of long-acting bronchodilators (ie, tiotropium and salmeterol). Even with therapy being in line with the current guidelines, the findings of the WISDOM trial indicate that not all patients benefit from including ICS in their treatment regimen. Indeed, only certain COPD phenotypes seem to benefit from ICS therapy, and validated markers that predict ICS response are urgently warranted in clinical practice. Furthermore, we are now better equipped with a larger armamentarium of novel and more effective long-acting β2-agonist/long-acting muscarinic antagonist combinations that can be considered by clinicians to optimize bronchodilation and allow for safer ICS withdrawal. In addition to providing a review of the aforementioned, this perspective article proposes an algorithm for the stepwise withdrawal of ICS in real-life clinical practice. Read the original article here: https://www.dovepress.com/applying-the-wisdom-of-stepping-down-inhaled-corticosteroids-in-patien-peer-reviewed-article-COPD
Просмотров: 903 Dove Medical Press
To access this issue of Topics in Focus: https://onlinelibrary.wiley.com/page/journal/14401843/special_article_collection_for_ats_2018? Special Article Collection for ATS 2018 To coincide with the ATS 2018 Conference, Respirology is offering free access until 30 June 2018 to the following papers specifically selected by the Editors in Chief with the conference attendees in mind. For more new content from Respirology, please visit the journal’s current issue, register to receive new content alerts or download the App. Asthma Pathophysiology of severe asthma: We’ve only just started King, G.G., James, A., Harkness, L. and Wark, P.A.B. Respirology 2018, 23: 262–271, doi: 10.1111/resp.13251 Severe asthma: We can fix it? We can try! McDonald, V.M., Maltby, S. and Gibson, P.G. Respirology 2018, 23: 260–261, doi: 10.1111/resp.13249 COPD Epidemiology, treatment, disposition and outcome of patients with acute exacerbation of COPD presenting to emergency departments in Australia and South East Asia: An AANZDEM study Kelly, A.M., Holdgate, A., Keijzers, G., Klim, S., Graham, C.A., Craig, S., Kuan, W.S., Jones, P., Lawoko, C. and Laribi, S. Respirology 2018, doi: 10.1111/resp.13259 Childhood measles contributes to post‐bronchodilator airflow obstruction in middle‐aged adults: A cohort study Perret, JL, Matheson, MC, Gurrin, LC, et al. Respirology 2018, doi: 10.1111/resp.13297 Interstitial Lung Disease Overlap of interstitial pneumonia with autoimmune features with undifferentiated connective tissue disease and contribution of UIP to mortality Kelly, B.T. and Moua, T. Respirology 2018, doi: 10.1111/resp.13254 Pulmonary hypertension in interstitial lung disease: Limitations of echocardiography compared to cardiac catheterization Keir, G.J., Wort, S.J., Kokosi, M., George, P.M., Walsh, S.L.F., Jacob, J., Price, L., Bax, S., Renzoni, E.A., Maher, T.M., MacDonald, P., Hansell, D.M. and Wells, A.U. Respirology 2018, doi: 10.1111/resp.13250 Lung Cancer Segmentectomy versus lobectomy in early non‐small cell lung cancer of 2 cm or less in size: A population‐based study Moon, M.H., Moon, Y.K. and Moon, S.W. Respirology 2018, doi: 10.1111/resp.13277 Pulmonary Vascular Disease Management of venous thromboembolism: Time to measure our performance Tan, M.W.Y., Chunilal, S. and Mansfield, D. Respirology 2018, 23: 246–247, doi: 10.1111/resp.13257 Respiratory Infections Pneumonia as a cardiovascular disease Restrepo, M.I. and Reyes, L.F. Respirology 2018, 23: 250–259, doi: 10.1111/resp.13233 Sleep Three‐dimensional photography for the evaluation of facial profiles in obstructive sleep apnoea Lin, S.‐W., Sutherland, K., Liao, Y.‐F., Cistulli, P.A., Chuang, L.‐P., Chou, Y.‐T., Chang, C.‐H., Lee, C.‐S., Li, L.‐F. and Chen, N.‐H. Respirology 2018, doi: 10.1111/resp.13261 Tuberculosis Tuberculosis vaccines: Opportunities and challenges Zhu, B., Dockrell, H.M., Ottenhoff, T.H.M., Evans, T.G. and Zhang, Y. Respirology 2018, 23: 359–368, doi: 10.1111/resp.13245 Update on tuberculosis biomarkers: From correlates of risk, to correlates of active disease and of cure from disease Goletti, D., Lee, M‐R., Wang, J‐Y., Walter, N. and Ottenhoff, T.H.M. Respirology 2018, doi: 10.1111/resp.13272 Music: Deliberate Thought by Kevin MacLeod is licensed under a Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) Source: http://incompetech.com/music/royalty-free/?keywords=deliberate+thought Artist: http://incompetech.com/
Просмотров: 45 Respirology Video
How Do You Diagnose Asthma? -- Dr. William Berger, MD (AHJ Diseases Illnesses) We have improved dramatically in our ability to diagnose asthma properly. Allergy testing now is done very easily, and we can identify which of the specific allergen triggers are important in causing the patient's asthma. We now have pulmonary function testing, which can actually measure air flow in the lungs, then give the patient medication and see if the air flow improves. This is how we make our diagnosis. After the diagnosis of asthma is made, there are a number of treatment options available. The decision to choose a treatment option depends on the severity of the asthma and the health of the patient. http://www.americanhealthjournal.com/allergies-asthma/how-do-you-diagnose-asthma-william-berger-md/ Subscribe: http://www.youtube.com/subscription_center?add_user=ahjdiseasesillnesses Facebook: http://www.facebook.com/AmericanHealthJournal Twitter: http://www.twitter.com/ahjhealth RSS: http://www.americanhealthjournal.com/feed/rss The American Health Journal is a highly rated, award-winning health care television program that airs on PBS and other national network affiliates which reaches over 30 million households. The American Health Journal has received over 91 national and international awards that include over 15 Telly Awards, over 15 Communicator Awards, 7 Vision Awards, 6 Davey Awards, just to mention a few. TAGS: "asthma diagnosis" "diagnosis of asthma" "how do you diagnose asthma" "asthma medications" "asthma medicines" "asthma disease diagnosis" "asthma" "american health journal" "american" "health" "journal" "ahj" "ahj videos" "healthcare" "health care" "medicine" "medical" "medical video" "health video" "doctor video"
Просмотров: 1026 AHJDiseasesIllnesses
Article Accompaniment: Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient. http://journals.sagepub.com/doi/full/10.1177/0148607115621863 Underfeeding versus full enteral feeding in critically ill patients with acute respiratory failure: a systematic review with meta-analysis of randomized controlled trials
Просмотров: 370 Jordan Miller
Dr. Warren Carr explains how asthma differs from COPD (chronic obstructive pulmonary disease). American Health Journal creates video content for medical professionals and medical patients relating to health and healthy living. American Health Journal's content provides information regarding symptoms, diagnosis, treatments, and research for all types of medical conditions such as cancer and cancer treatments, diabetes, addiction, cardiology, children's health, mental health, ophthalmology, plastic surgery, podiatry, sleep disorders, and other medical categories so that medical professionals and medical patients have most accurate and recent medical information. Website: http://www.thedoctorshow.com/ Facebook: https://www.facebook.com/AmericanHealthJournal/ Twitter: https://twitter.com/AHJDiabetes HealthFeed YouTube:https://www.youtube.com/channel/UCv1l2E6-vWVOAH6mW_xAdXQ Facebook: https://www.facebook.com/HealthFeedNetwork Twitter: https://twitter.com/healthfeed_en Pinterest: https://www.pinterest.com/healthfeed/
Просмотров: 42 American Health Journal
Very exciting research has surfaced in the last few years in regard to the health benefits of the bitter taste receptors that were discovered to exist not only in the mouth but also in the nasal cavity, lungs, and GI tract. Benefits of bitter compounds include reducing hunger, increasing satiety hormones, inducing GLP-1 (an anti-diabetic peptide), and in animal models bitter compounds can reduce lung inflammation and battle asthma. Select References: Lee et al 2016. Scientific American Minella et al 2016. British Journal of Nutrition Kim et al. 2014. Diabetologia Tunnicliffe et al. 2008. APNM Greenberg et al. 2012. JACN I am a scientist simply sharing scientific evidence. Please do consult the advice of your physician before making any lifestyle changes. My opinions expressed in these videos do not necessarily reflect the opinions of Mount Sinai and its affiliates.
Просмотров: 56 The People’s Scientist
Kutki Treatment for Bronchial Asthma and Epidemic Jaundice (@ www.yousigma.com, By: Deepak Chebbi)
Просмотров: 384 Deepak Chebbi
Highlights: - The therapy has no evidence of toxicity or noticeable side effects in human patients. Scientists at the University of Rochester hope to reposition this compound as an anti-inflammatory agent for the treatment of COPD - Vinpocetine is a well-known natural product that was originally discovered nearly 30 years ago and is currently used as a dietary supplement for the prevention and treatment of cognitive disorders, such as stroke and memory loss, in Europe, Japan and China. * Proceedings of the National Academy of Sciences 3 MAY 2010 Kye-Im Jeon, 9795–9800, doi: 10.1073/pnas.0914414107 - Vinpocetine inhibits NF-κB–dependent inflammation via an IKK-dependent but PDE-independent mechanism ** http://www.pnas.org/content/107/21/9795.full - http://healthresearchreport.me/2014/02/06/purple-periwinkles-battle-inflammatory-diseases/
Просмотров: 24299 VHFILM
► The Enzyme That Fight Cancer, Treat Digestive Disorders, Allergies, And Much More Have you ever heard about bromelain? Bromelain is a protein-digesting enzyme complex found in the fruit and, in higher concentrations, in the stem of the pineapple. Put simply, bromelain breaks down protein. Studies have shown that, bromelain has the ability to treat many health issues. Thanks to its anti-inflammatory and anti-swelling properties, bromelain health benefits include the ability to treat digestive disorders, reduce joint pain, fight allergies and even help prevent cancer. The health benefits of bromelain. Traditionally societies in South America have used pineapples, to reduce digestive upset and reduce irritation. Here are some of the other amazing health benefits of this enzyme, as well as the studies that support the benefits of bromelain: 1. May help prevent cancer. In studies, bromelain has been found to have natural anti-cancer effects, including promoting apoptotic cell death, and preventing tumor growth. Bromelain is able to induce the production of cytokines, that inhibit the development of cancer. Studies have shown, a link between bromelain and increased protection against breast cancer and lung cancer. 2. Help treat digestive disorders. Because bromelain is an enzyme, it specifically helps with digesting proteins, and has been found to help your body absorb nutrients, and even medications more efficiently. Studies have shown that, bromelain can decrease inflammation in the colon and help treat ulcerative colitis, inflammatory bowel disease, constipation, Crohn’s disease and diarrhea. 3. Supports quick healing after surgery or injuries. Bromelain was approved in Europe as an effective remedy for swelling after surgery. Research shows that, the bromelain enzyme may lower swelling, stop bruising, speed up healing time, and reduce discomfort in individuals following surgical procedures. Bromelain works as a natural alternative to pain medication, by decreasing swelling and reducing pain. Studies have shown that, surgery patients treated with bromelain experienced significantly lower post-operation pain, swelling, and redness, compared to those treated with a generic painkiller. 4. Fights allergies and asthma. Research has shown that, bromelain health benefits include the ability to fight allergies and asthma. According to a study published in the journal Evidence-Based Complementary and Alternative Medicine, bromelain was able to reduce allergic sensitization, and prevent the development of inflammatory responses in mice suffering from asthma. The research suggests that, bromelain can help prevent asthma and seasonal allergy symptoms by getting to the root of the problem. It helps to prevent an inflammatory response in a hyperactive, oversensitive immune system. 5. Helps prevent and treats sinus infections. There are several studies that, suggest bromelain may help reduce coughing and lessen mucus related to sinusitis, as well as reduce the swelling and redness that accompany hay fever. The German Commission E approved the bromelain enzyme for aiding imbalances of the ear, nose, and throat that occur after surgery. It is also approved for reducing general sinus infection swelling. 6. Help reduce joint pain. Due to its powerful anti-inflammatory and analgesic characteristics, bromelain is fantastic for reducing acute or chronic joint pain. In a study published in Alternative Therapies in Health and Medicine, researchers treated osteoarthritis with two 650-milligram capsules of bromelain 2-3 times per day. The patients experienced up to a 60 percent decrease in acute pain, and more than a 50 percent decrease in chronic pain. 7. May support weight loss. Research suggests that, bromelain health benefits may include the ability to prevent the formation of fat cells and aid in weight loss. Bromelain’s ability to fight inflammation, reduce joint pain and aid in digestion help improve the body’s physical capabilities. According to a 2017 study, bromelain may even work as an anti-obesity alternative medicine. ★ Please leave a like if you enjoyed and tell me what you think in the comments! ★ Don't forget to subscribe my channel to help us reach to 100.000 Subscribers : https://goo.gl/29sHF2 --------------------------------------------------------------------------------- ★ VIEW MORE: ➞ Tips & Tricks: https://goo.gl/UdhRLs ➞ Natural Remedies: https://goo.gl/djrthu ➞ Diet & Weight Loss: https://goo.gl/7sEJCX ➞ Beauty Tips: https://goo.gl/E3nsCd ➞ Healthy Drinks: https://goo.gl/BSGh2E --------------------------------------------------------------------------------- ★ Like our facebook page: https://goo.gl/tVNSqu --------------------------------------------------------------------------------- ★ Videos can use content-based copyright law contains reasonable use Fair Use (https://www.youtube.com/yt/copyright/)
Просмотров: 699 Good Health and Nutrition
Video abstract of case report paper "Rare case of pneumorrhachis, pneumomediastinum, pneumothorax, and surgical emphysema secondary to bronchial asthma" published in the open access International Medical Case Reports Journal by Parag Suresh Mahajan, Nasser Jassim Al Maslamani and Nishan K Purayil. Abstract: Air localized within the spinal canal is called pneumorrhachis. In the case of pneumorrhachis, air can be present in the extradural, the intradural, or the subarachnoid space of the spinal canal. Read this case report and sign up to receive International Medical Case Reports Journal here: http://www.dovepress.com/rare-case-of-pneumorrhachis-pneumomediastinum-pneumothorax-and-surgica-peer-reviewed-article
Просмотров: 245 Dove Medical Press
Douglas B. Evans, MD interviews Marc A. de Moya, MD from the Department of Surgery at the Medical College of Wisconsin. The interview discusses the importance of training and research. The video also examines trauma, critical care and acute care surgery and services offered by Froedtert and the Medical College of Wisconsin.
Просмотров: 743 Medical College of Wisconsin
An internationally acclaimed ayurvedic physician cum researcher who practices and a pioneer in introducing "Evidently Effective Protocol based Ayurvedic treatment for the patients of - Acute promyelocytic leukemia (APML, APL), Chronic Pancreatitis, Migraine, Childhood Asthma, Allergic Rhinitis/Cyanosis and Nutritional Anaemia. He is an author or 19 research papers which has been published in various national and international medical journals. He has also begged 2 patents for his invention in the field of medicine . He was assigned honorary physician to the tenth President of India Shri Kocheril Raman Narayanan. He is also a recipient of Padmashree (1999) the fourth highest civilian award in the Republic of India for his excellence in Ayurveda.
Просмотров: 3471 Vaidya Balendu Prakash
For more news and videos visit ☛ http://english.ntdtv.com Follow us on Twitter ☛ http://twitter.com/NTDTelevision Add us on Facebook ☛ http://facebook.com/NTDTelevision And now a breakthrough in asthma research in Australia. Scientists claim that a new genetic discovery could mean freedom from an inhaler as asthma sufferers might be able to use an arthritis drug to treat their condition. Maryanne Venables has chronic asthma. [Maryanne Venables, Asthma Patient]: "I can't go anywhere without my little gray friend, my little Ventolin inhaler." Like many asthmatics, she has long hoped for a drug breakthrough that makes managing the condition easier. Now, there may be one. In "The Lancet" medical journal, Australian researchers say they have found that asthmatics share a common gene with sufferers of rheumatoid arthritis. And there's already a drug on the market, Tocilizumab, to treat rheumatoid arthritis. The hope is that the drug, which reduces arthritis inflammation, can also reduce inflammation in asthmatics. Dr. Manuel Ferreira is one of the scientists. [Dr. Manuel Ferreira, Researcher]: "It's a drug that reduces the activity of the gene that we've now found has something to do with asthma." [Maryanne Venables, Asthma Patient]: "I think it certainly uncovers ground that doesn't seem to have been addressed before." More than 235 million people worldwide have asthma and the World Health Organization says it's the most common chronic disease among children. [Maryanne Venables, Asthma Patient]: "I use a preventer, and I use an inhaler. If there are clinical trials in the future, if I was eligible for them I'd be very interested in participating." The researchers say more study needs to be conducted to asses the drug's effectiveness in treating asthma.
Просмотров: 2286 NTDTV
The N Engl J Med image of the week shows a man with a red face. You are offered auriculotemporal nerve syndrome, carcinoid syndrome, mastocytosis, pheochromocytoma, and rosacea. We go over each condition. We revisit the case from last week with sternal tuberculosis and review his CT scan. Exemestane is an aromatase inhibitor that blocks the conversion from testosterone to estrogen. Adjuvant therapy with an aromatase inhibitor could improve outcomes, as compared with tamoxifen, in postmenopausal women with hormone-receptor--positive breast cancer. Investigators randomly assigned premenopausal women with hormone-receptor--positive early breast cancer to exemestane plus ovarian suppression or tamoxifen plus ovarian suppression for a period of 5 years. Suppression of ovarian estrogen production was achieved with the use of the gonadotropin-releasing-hormone agonist triptorelin, oophorectomy, or ovarian irradiation in both groups. Exemestane reduced disease recurrence, but not overall survival. Clomiphene is the current first-line infertility treatment in women with the polycystic ovary syndrome, but aromatase inhibitors, including letrozole, might result in better pregnancy outcomes. Letrozole beat clomiphene in these BMI 35 ladies. Dupilumab, a fully human monoclonal antibody, which blocks interleukin-4 and interleukin-13, has shown efficacy in patients with asthma and elevated eosinophil levels. The blockade by dupilumab of these key drivers of type 2 helper T-cell (Th2)--mediated inflammation could help in the treatment of related diseases, including atopic dermatitis. The findings provide evidence that allergic asthma and atopic dermatitis might have related drivers — in particular, interleukin-4 and interleukin-13 — and that these diseases may benefit from the same therapeutic approach. In the Total Body Hypothermia for Neonatal Encephalopathy Trial (TOBY), newborns with asphyxial encephalopathy receiving hypothermic therapy had improved neurologic outcomes at 18 months of age, but it is uncertain whether such therapy results in longer-term neurocognitive benefits. Now we are certain. The recent outbreak of Exserohilum rostratum meningitis linked to epidural injections of methylprednisolone acetate has brought renewed attention to mold infections of the central nervous system (CNS). Although uncommon, these infections are often devastating and difficult to treat. We review the topic. The mystery case of the week is a 68-year-old man with ANCA vasculitis who develops diplopia and other CNS manifestations. In the Lancet, evidence suggests that brief physiotherapy programs are as effective for acute whiplash-associated disorders as more comprehensive programs; however, whether this also holds true for chronic whiplash-associated disorders is unknown. Turns out that brief treatment is as good as comprehensive physiotherapy for long-term whiplash results. Postoperative surgical site infections are one of the most frequent complications after open abdominal surgery, and triclosan-coated sutures were developed to reduce their occurrence. The aim of the PROUD trial was to obtain reliable data for the effectiveness of triclosan-coated PDS Plus sutures for abdominal wall closure, compared with non-coated PDS II sutures, in the prevention of surgical site infections. Unfortunately, triclosan did not help. Poor adherence to treatment diminishes its individual and public health benefit. Financial incentives, provided on the condition of treatment attendance, could address this problem. Injecting drug users (heroine addicts) are a high-risk group for hepatitis B virus (HBV) infection and transmission, but adherence to vaccination programs is poor. Investigators aimed to assess whether contingency management (paying them to complete vaccination) delivered in routine clinical practice increased the completion of HBV vaccination in individuals receiving opioid substitution therapy. Bribes generally work. We then inspect an important meta-analysis of breast cancer patients treated with neoadjuvant chemotherapy (more advanced disease given chemotherapy before surgery). A "pathological complete response" is deemed to be an important prognostic indicator. We learn the prognostic value and limitations of this pathological result. The Lancet case is a 92 year-old lady with knee pain that turns out to be an obturator hernia. We review this treacherous diagnosis.
Просмотров: 292 Clinical Journal Club
Asthma: Facts Scientific research has proven that chiropractic corrective care boosts immunity and reduces asthma symptoms by removing neurological interference and restoring proper biomechanics to the spine. Here are the results. • Improved breathing and heightened sense of smell • Reduced wheezing and shortness of breath with activity • Decreased frequency of episodes (by an average of 44.9%) • Decreased medication consumption • Reduced number of pediatric hospitalizations • Improved sleep patterns and quality of sleep • Decreased anxiety. People of all ages enjoy the benefits of specific scientific chiropractic care. Who do you know that would benefit from understanding that they can reduce the amount of medication they take and improve their overall quality of life through chiropractic corrective care? RESEARCH REFERENCES Blum C.L. Role of chiropractic and sacro-occipital technique in asthma treatment. J Chiro Med. 2002;38(8):325-328. Monti, R L Mechanisms and chiropractic management of bronchial asthma. Dig Chiro Econ 1981; 24(2):48,50-1. Rectenwald R. Resolution of Severe Chronic, Asthma in an Infant Following Upper Cervical Chiropractic Care to Reduce Subluxation. Journal of Pediatric, Maternal Be Family Health. 2000. Atlas Chiropractic Dr. Jim McCann 1353 Dwight Street Holyoke, MA 01041 (413) 538-8808 Dr. Jim McCann demonstrates an Atlas Specific adjustment using an arthrostim Instrument. Dr. Jim developed an intense interest in low force “tonal” techniques while at Life Chiropractic College (Life University) and over the years has done a great deal of additional training in Network Spinal Analysis, in Atlas orthogonal Technique, in Sacro-Occipital technique, in Thompson Technique, in Logan basic Technique, in Activator technique and in Toftness Technique. By combining some or all these techniques he has developed his own unique conservative method of restoring normal Spinal alignment and neural integrity. He lives in Westfield with his wife Kathy and their dog Brownie. His burning desire is to introduce as many people as possible to the miracle of Chiropractic. His key to success is to follow your heart and do what you love. His hobbies are motorcycles and airplanes. Something no one knows about him is that he was 1979 New England States Power-lifting Champion and 1984 New England ‘ s strongest man runner-up. Curriculum Vitae 1971 Graduated from St. Paul Catholic. High School in Bristol Connecticut 1972-1974 Served in the U.S. Army as a Medic in the Medical Corps. 1974-1976 Graduated Manchester Community College with an A.S. in Respiratory Therapy. 1976-1979 Employed as a Respiratory Therapist in the acute care setting. 1979-1989 Owned and Operated two Fitness Facilities; 1989-1991 Employed again as a Respiratory Therapist in the Chronic Care at Western Mass Hospital. 1991-1995 Attended and Graduated from Life University of Chiropractic in Marietta, Georgia. 3/1995-1/1996 Owned and operated Chiropractic Clinic in Mobile Alabama. 2/1996-10/1997 Manage and Operated a Chiropractic office in Holyoke Ma for Bisanti Chiropractic and Rehabilitation. 11/1997- Present Owner/Operator Atlas Chiropractic 1353 Dwight St. Holyoke MA 01040 Member World Chiropractic Alliance International Chiropractic Association Massachusetts Chiropractic Society Chiropractic Leadership Alliance AMC Chiropractic Group March 2004 Completed Study with the National University of Health Sciences Impairment Rating for Disability Evaluation using the AMA Guides the Evaluation of Permantent Impairment. Graduate: Whiplash The Master Program: Spine Research Institute of San Diego April 2011 Advanced Certificate of Competency Spine Research Institute of San Diego
Просмотров: 29 James McCann
Stan Szefler, MD talks with Michael Wechsler, MD about Dr. Wechsler's new JACI article "Bronchial thermoplasty: Long-term safety and effectiveness in patients with severe persistent asthma". This article is available with free access here: http://www.jacionline.org/article/S0091-6749(13)01268-2/fulltext Key words: Bronchial thermoplasty, asthma, bronchoscopic procedure, Alair System, asthma exacerbation
Просмотров: 511 JAllergyClinImmunol
A discussion of the controversies surrounding the RE-LY and ROCKET-AF trials, which led to the initial FDA approvals of dabigatran (Pradaxa) and rivaroxaban (Xarelto) respectively. Please note that in the 2 years since this video was posted, additional studies have been published which support the use of these drugs. I leave the video up because the issues discussed are still relevant. However, if you are a layperson, please do NOT stop taking your Xarelto or Pradaxa just because you watched this video. Instead, discuss your concerns with your physician. There are more than one alternative anticoagulants out there. I declare that I have no conflicts of interest, and receive no compensation from the pharmaceutical or device industries. Original RE-LY Trial: http://www.ncbi.nlm.nih.gov/pubmed/19717844 Original ROCKET-AF Trial: http://www.ncbi.nlm.nih.gov/pubmed/21830957 BMJ Criticisms of Dabigatran RE-LY: http://www.ncbi.nlm.nih.gov/pubmed/25056265 http://www.ncbi.nlm.nih.gov/pubmed/25055831 http://www.ncbi.nlm.nih.gov/pubmed/25055829 BMJ Criticism of ROCKET-AF and Rivaroxaban: http://www.ncbi.nlm.nih.gov/pubmed/26843102 Recent media coverage of dabigatran and RE-LY: https://www.washingtonpost.com/news/federal-eye/wp/2015/10/15/fda-was-lax-and-kowtowed-to-drugmaker-in-review-of-controversial-blood-thinner-watchdog-says/ http://www.nytimes.com/2014/02/08/business/new-emails-in-pradaxa-case-show-concern-over-profit.html http://www.nytimes.com/2014/02/06/business/study-of-blood-clot-drug-pradaxa-unnerved-its-maker-documents-suggest.html Recent media coverage of rivaroxaban and ROCKET-AF: http://www.nytimes.com/2016/02/23/business/fda-asks-if-faulty-blood-monitor-tainted-xarelto-approval.html?_r=0 http://www.cbsnews.com/news/did-heart-drug-makers-withhold-data-from-medical-journal/
Просмотров: 39778 Strong Medicine
GAINESVILLE, Fla. --- Pharmacy researchers at the University of Florida have isolated a new marine compound they believe may lead to improved drug therapies for pulmonary diseases by inhibiting their progression rather than managing their symptoms. Known as symplostatin 5, the compound was extracted from blue-green algae collected in Cetti Bay, Guam, by Hendrik Luesch, the Frank A. Duckworth eminent scholar chair in drug research and development. The new compound targets an enzyme overactive in chronic obstructive pulmonary disease, asthma, acute respiratory distress syndrome, cystic fibrosis and other diseases. "These compounds can potentially offer a new opportunity to treat COPD and related diseases in a different way and possibly more effectively," Luesch said. COPD is the fourth leading cause of death in the United States, killing more than 120,000 Americans each year, according to the Centers for Disease Control and Prevention. Current therapies alleviate symptoms of COPD, but do not slow disease progression. Only one drug, Sivelestat, targets the enzyme, called elastase, but its marginal effects are delaying further clinical approvals, Luesch said. Elastase is an enzyme that breaks down a variety of proteins. In COPD, where there is excessive enzyme activity, this contributes in part to lung damage and inflammation. The effects of elastase on these processes contribute to the irreversible destruction of lung tissues typically observed in COPD patients. Lilibeth Salvador, a researcher in Luesch's Marine Natural Products lab, led the investigation published Feb. 14 in the Journal of Medicinal Chemistry. The study revealed that the blue-green algae prevented elastase-driven changes in bronchial connective tissue cells. She is also presenting the findings at the college's 26th Annual Research Showcase on Thursday. Salvador, who will earn her doctorate from the UF College of Pharmacy in May, uses a soccer analogy to describe how the compound may prove to be a more effective drug therapy.
Просмотров: 996 UFHealth
Get your Black Seed Oil Here--- http://amzn.to/2vuGalS Get your Berberine here---- http://amzn.to/2fAqbP9 Black Seed is a plant from Ranunculaceae (buttercup) family. It originates from Western Asia. It has white flowers when in bloom. For over 2 centuries, black seed has been used by different cultures as a natural remedy for varied diseases and improve our health and well-being. Ancient Egyptians knew its benefits and called it a panacea (cure for illnesses) whereas the Ancient Romans utilized it as part of a diet and called it Greek Coriander. Ancient Greeks used it for aches of the head and teeth as well as nasal congestion. Our Beloved Prophet peace be upon him: ‘Use the Black Seed for indeed, it is a cure for all diseases except death.’ [Sahih Bukhari - 7:591] Current Research Studies have shown that its active ingredient, crystalline nigellone, contains 15 amino acids. Amongst these include 8 essential amino acids. It also has carbohydrates, fatty acids including linolenic and oleic acids, alkaloids, volatile oils, and dietary fibre, as well as minerals such as calcium, iron, sodium and potassium. Recent studies have shown that black seed is an antibiotic, anti-tumour, anti-inflammatory, anti-histaminic, anti-bacterial, anti-bronchial and immune-boosting agent. Some studies have shown it has trypanocidal properties and can stimulate the host immune system to maintain parasite proliferation. Consequently, it can help manage African sleeping sickness despite there is a risk of damage gradually occurring to host organs (shown due to increase in serum enzymes). What does Black Seed Oil contain? Black Seed Oil contains 3 main natural phytochemicals: thymoquinone (TQ), thymohydroquinone (THQ) and thymol. A study published in the Egyptian Journal of Biochemistry & Molecular Biology experimented these 3 natural chemicals against 30 human pathogens. Results suggested that all three chemicals showed 100% inhibition for these pathogens. Thymol - It is also present in thyme. It is a natural monoterpene. It is useful against fungus and viruses. Studies found it to be the best anti-fungal agent followed by TQ and THQ. It is also used in cosmetics and food flavouring. Thymoquinone - It has anti-tumour, anti-oxidant, anti-inflammatory properties. Studies have shown it to aid with asthma, diabetes, carcinogenesis and encephalomyelitis. It preserves anti-oxidant enzymes glutathione peroxidase and glutathione-S-transferase as they detoxify and aid in cellular anti-oxidant defense systems as they protect the liver from toxins. Thymohydroquinone - It is a natural acetylcholinesterase (AChE) inhibitors that aims to stop enzymatic activitity which increase the amount of neurotransmitter acetylecholine remains active in the brain. These AChE inhibitors treat Schizophrenia, Glaucoma, Alzheimer’s disease, apathy and other conditions.
Просмотров: 1307 Chris Delano